Acta Vet. Brno 2006, 75: 523-532

Effect of an Acute Iron Overdose on PMN Cells Chemiluminescence and Indices of Inner Environment in a Swine Model

M. Svoboda1, A. Lojek2, J. Polášková1, R. Ficek1, J. Hiemer3, J. Drábek1

1University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
2Institute of Biophysics, Brno, Academy of Sciences of the Czech Republic
3Berlin Chemie, s.r.o., Praha, Czech Republic

Received May 22, 2006
Accepted September 5, 2006

The objective of the study was to evaluate the effect of an acute iron dextran administration on polymorphonuclear cells chemiluminescence and indices of inner environment in piglets. Piglets in the experimental group (n = 16) were given 2000 mg (20 ml) Fe3+ in the form of iron dextran i.m. Piglets in the control group (n = 13) were given the same amount of physiological saline. Blood was taken before administration, and 1, 4 and 24 hours after. Iron application resulted in a ten times higher concentration of iron in blood plasma in the experimental group. No differences in spontaneous, PMA- and OZP-stimulated chemiluminescence were recorded between the two groups. The increased activities of CK, AST and LDH are indicative of a muscle injury at the injection site. No changes indicating liver or kidney injury were reported. Our study provides evidence of a good safety of iron dextran after parenteral administration.