Acta Vet. Brno 2009, 78: 115-120

Experimental Assessment of a New Type of Carbon-Coated ARTECOR® Vascular Prosthesis in Sheep

Jiří Podlaha1, Martin Dvořák1, Věra Žižková2, Rudolf Dvořák3, Radovan Kabeš3, Miroslav Jelínek4, Karel Veselý5

12nd Department of Surgery, Faculty of Medicine, Masaryk University, St. Anne’s University Hospital Brno, Czech Republic
2Knitting Research Institute, Brno, Czech Republic
3Clinic of Ruminants Diseases, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
4Institute of Physics of the ASCR, Prague, Czech Republic
5Department of Pathology, Faculty Of Medicine, Masaryk University, St. Anne’s University Hospital Brno, Czech Republic

Received April 16, 2008
Accepted November 12, 2008

The aim of the study was to test and verify the characteristics of a new type of carbon-coated ARTECOR® vascular prosthesis developed at the Knitting Research Institute, a.s. Brno. Eight healthy Merino sheep, aged between 2 and 3 years, were implanted four types (A, B, C with diamond-like carbon (DLC) coating and D as a control without DLC) of vascular prostheses. The site of implantation was the common carotid artery; the length of the implant was 7 cm. All sheep received antibiotics prophylactically in accordance with the theory of the so-called “protected coagulum”. Doppler ultrasound examination was performed before finishing the operation to verify the patency of each prosthesis. During the study period the animals were closely observed. Prostheses were extirpated on day +/- 100 in 6 sheep and on day 182 in 2 sheep. Type B prosthesis showed better results according to its postoperative patency. The implant lumen was constantly 7 mm, whereas the use of other types resulted in lumen narrowing. Type B prosthesis has a deposition of DLC coating of a thickness of 20 nm with a high content of sp3 bonds (more diamond-like ones). The experimental type B of prosthesis ARTECOR® appears to be the most successful of the tested prostheses (at the end of the study all B-type prostheses remained patent). This prosthesis appears to better satisfy the rheologic characteristics for healing.