Acta Vet. Brno 2009, 78: 491-496

https://doi.org/10.2754/avb200978030491

Endocannabinoid Brain System Involvement in dopamine mechanisms of behavioural sensitization to psychostimulants

Dagmar Vršková

Department of Pharmacology, Faculty of Medicine, Masaryk University Brno, Czech Republic

Received May 19, 2008
Accepted May 18, 2009

The paper deals with the involvement of endocannabionid brain system in dopamine mechanisms of behavioural sensitization to psychostimulants. The development and manifestation of behavioural sensitization to methamphetamine are described. Results obtained in our previous studies, showing an interaction between the endocannabinoid system and methamphetamine brain mechanisms, in the rat intravenous drug self-administration model and with qPCR CB1 mRNA expression, are discussed.

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