Acta Vet. Brno 2010, 79: 61-65

Ventilation and Haemodynamic Indicators in Spontaneously Breathing Pigs under General Anaesthesia

Jiří Kobr1, Vilém Kuntscher2, Vladislav Třeška2, Jiří Moláček2, Václav Vobruba3, Jiří Fremuth1

1Charles University in Prague, Faculty of Medicine in Pilsen and Department of Paediatrics – Paediatric Intensive Care Unit, Faculty Hospital in Pilsen
2Charles University in Prague, Faculty of Medicine in Pilsen and Department of Surgery, Faculty Hospital in Pilsen
3Charles University in Prague, First Faculty of Medicine and Department of Paediatrics – PICU, General Faculty Hospital in Prague

Received December 17, 2008
Accepted June 30, 2009

The aim of this study was to obtain ventilation and haemodynamic data of healthy piglets under general anaesthesia for future patho-physiological experimental studies. A total of 34 domestic piglets of the Czech Black Pied (Přeštice) breed were used in the study. The animals (male to female ratio 8 : 9) were six weeks old and their average body mass was 22 kg. A general anaesthetic (fentanyl and azaperon) was introduced via a pulmonary artery catheter and the spontaneously breathing animals were monitored for 60 min. Cardiac output and haemodynamic indicators were established using intermittent pulmonary artery thermodilution. Blood gas data were deduced using fan dynamic parameters of ventilation and ventilation indices. The study yielded reliable data of dynamic lung indicators (p < 0.05); e.g. the tidal volume 6.00 ± 0.82 ml/kg, hypoxemic index 350.47 ± 42.50 mmHg, lung compliance 0.63 ± 0.12 ml/cmH2O/kg, and haemodynamic indicators (p < 0.01) such as cardiac output 2.12 ± 0.75 l/min, pulmonary vascular resistance 3.92 ± 0.52 and systemic vascular resistance 15.8 ± 6.81 Woods units. Reliable data regarding lung dynamics, cardiac output, preload and afterload of both heart ventricles in spontaneously breathing healthy piglets under general anaesthesia were achieved.


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