Acta Vet. Brno 2010, 79: 127-133

Expression of Claudin-7 Molecule in Canine Perianal GlandTumours

Csaba Jakab1, Miklós Rusvai1, Péter Gálfi2, Janina Kulka3

1Szent István University, Faculty of Veterinary Science, Department of Pathology and Forensic Veterinary Medicine, Budapest, Hungary
2Szent István University, Faculty of Veterinary Science, Department of Pharmacology and Toxicology, Budapest, Hungary
32nd Department of Pathology, Semmelweis University, Budapest, Hungary

Received January 2, 2008
Accepted September 8, 2009


1. Amasheh S, Meiri N, Gitter AH, Schoneberg T, Mankertz J, Schulzke JD, Fromm M 2002: Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 115: 4969-4976 <>
2. Banan A, Zhang LJ, Shaikh M, Fields JZ, Farhadi A, Keshavarzian A 2005: Theta isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. J Pharmacol Exp Ther 313: 962-982 <>
3. Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, Neff J, Washington MK, Beauchamp RD 2005: Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Inv 115: 1765-1776 <>
4. D’souza T, Agarwai R, Morin PJ 2005: Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J Biol Chem 280: 26233-26240 <>
5. Fujibe M, Chiba H, Kojima T, Soma T, Wada T, Yamashita T, Sawada N 2004: Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp Cell Res 295: 36-47 <>
6. Furuse M, Sasaki H, Tsukita S 1999: Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 147: 891-903 <>
7. Goldschmidt M, Hendrick M 2000: Tumors of the skin and soft tissue. In: Meuten, D. (Ed.), Tumor in domestic animals, 4th edition, Iowa State Press, pp. 68-70
8. Goldschmidt M, Shofer F 1992: Skin tumors of the dog and cat. Pergamon Press, Oxford, pp. 66-71
9. Gregory M, Dufrense J, Hermo L, Cyr DG 2001: Claudin-1 is not restricted to tight junctions in the rat epididymis. Endocrinol 142: 854-863 <>
10. Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S 2002: Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem 277: 455-461 <>
11. Hornsby CD, Cohen C, Amin MB, Picken MM, Lawson D, Yin-Goen Q, Young AN 2007: Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling. Arch Pathol Lab Med 131: 1541-1547
12. Ihrke PJ, Walder EJ, Affolter VK 2006: Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. 2nd Edition, Blackwell Publishing, pp. 655-665
13. Ishizaki T, Chiba H, Kojima T, Fujibe M, Soma T, Miyajima H, Nagasawa K, Wada I , Sawada N 2003: Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways. Experim Cell Res 290: 275-288 <>
14. Isistor GN, Weinman DE 1979: Origin and early development of canine circumanal glands. Am J Vet Res 40: 487-492
15. Jakab Cs, Halász J, Szász AM, Batmunkh E, Kiss A, Schaff Zs, Rusvai M, Gálfi P, Kulka J 2008a: Expression and localisation of claudin-1, -2, -3, -4, -5, -7 and -10 proteins in the normal canine mammary gland. Acta Vet Hung 56: 341-352 <>
16. Jakab Cs, Halász J, Kiss A, Schaff Zs, Rusvai M, Kulka J 2008b: Use of external positive controls in claudin-expression immunohistochemical examination [in Hungarian, with English abstract and figures]. Magy Állatorvosok Lapja 130: 433-438
17. Jakab Cs, Halász J, Szász AM, Kiss A, Schaff Zs, Rusvai M, Gálfi P, Kulka J 2008c: Expression of claudin-1, -2, -3, -4, -5, and -7 proteins in benign and malignant canine mammary gland epithelial tumours. J Comp Pathol 139: 238-245 <>
18. Jakab Cs, Szász AM, Kiss A, Schaff Zs, Rusvai M, Szabára Á, Kulka J 2009: Immunohistochemical examination of expression patterns of claudin molecules in metastases of solid carcinoma simplex from canines [in Hungarian, with English abstract and figures]. Magy Állatorvosok Lapja, 131: 33-41.
19. Johnson AH, Frierson HF, Zaika A, Powell SM, Roche J, Crowe S, Moskaluk CA, El-Rifai W 2005: Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Am J Pathol 167: 577584 <>
20. Karen S, Robert M, Manfred K 2005: Role of claudins in tumorigenesis. Adv Drug Del Rev 57: 919-928
21. Kominsky SL, Argani P, Korz D, Evron E, Raman V, Garrett E, Rein A, Sauter G, Kallioniemi OP, Sukumar S 2003: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene 22: 2021-2033 <>
22. Kominsky SL, Vali M, Korz D, Gabig TG, Weitzman SA, Argani P, Sukumar S 2004: Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4. Am J Pathol 164: 1627-1634 <>
23. Li Wy, Huey CL, Yu As 2004: Expression of claudin-7 and -8 along the mouse nephron. Am J Physiol Renal Physiol 286: 1063-1071 <>
24. Miwa N, Furuse M, Tsukita S, Niikawa N, Nakamura Y, Furukawa Y 2000. Involvement of claudin-1 in beta-catenin/Tcf signaling pathway and its frequent upregulation in human colorectal cancers. Oncol Res 12: 469-476 <>
25. Miyaori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H 2001: Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases. J Biol Chem 276: 28204-28211 <>
26. Montgomery E, Mamelak AJ, Gibson M, Maitra A, Sheikh S, Amr SS, Yang S, Brock M, Forastiere A, Zhang S, Murphy KM, Berg KD 2006: Overexpression of claudin proteins in esophageal adenocarcinoma and its precusor lesions. Appl Immunohistochem Mol Morphol 14: 24-30 <>
27. Morita K, Furuse M, Fujimoto K, Tsukita S 1999: Claudin multigene family encoding four transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci USA 96: 511-516 <>
28. Mullin JM 1997: Potential interplay between luminal growth factors and increased tight junction permeability in epithelial carcinogenesis. J Experim Zool 279: 484-489 <<484::AID-JEZ11>3.0.CO;2-8>
29. Mullin JM 2004: Epithelial barriers, compartmentation, and cancer. Sci STKE 216: 2-4
30. Sobel G, Paska Cs, Szabó I, KissA, Kádár A, Schaff Zs 2005: Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive carcinoma. Human Pathol 36: 162-169 <>
31. Tsukita S, Furuse M 2002: Claudin-based barrier in simple and stratified cellular sheets. Curr Opin Cell Biol 14: 531-536 <>
32. Tsukita S, Furuse M, Itoh M 2001: Multifunctional strands in tight junctions. Nat Reviews Mol Cell Biol 2: 285-293 <>
33. Usami Y, Chiba H, Nakayama F, Ueda J, Matsuda Y, Sawada N, Komori T, Ito A, Yokozaki H 2006: Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus. Human Pathol 37:569-577 <>
34. Van Itallie C, Rahner C, Anderson JM 2001: Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Investig 50: 1319-1327
35. Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S 2004: Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci USA 101: 4690-4694 <>
36. Zheng J, Xie Y, Campbel R, Song J, Massachi S, Razi M, Chiu R, Berenson J, Yang OO, Chen IS, Pang S 2005: Involvement of claudin-7 in HIV infection of CD4(-) cells. Retrovirol 2: 79-92 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue