An analysis of CYP19, CYP21 and ER genotypes in Polish Holstein-Friesian cows with regard to the selected reproductive traits

Szatkowska, Iwona; Grzesiak, Wilhelm; Jędrzejczak, Magdalena; Dybus, Andrzej; Zaborski, Daniel; Jankowiak, Dorota

doi:10.2754/avb201180010065

Acta Veterinaria > Archive > 2011, Vol. 80 > Issue 1 > An analysis of CYP19,…

Acta Vet. Brno 2011, 80: 65-71

https://doi.org/10.2754/avb201180010065

An analysis of CYP19, CYP21 and ER genotypes in Polish Holstein-Friesian cows with regard to the selected reproductive traits

Iwona Szatkowska¹, Wilhelm Grzesiak², Magdalena Jędrzejczak¹, Andrzej Dybus¹, Daniel Zaborski², Dorota Jankowiak³

¹Laboratory of Molecular Cytogenetics, West Pomeranian University of Technology in Szczecin, Szczecin, Poland
²Laboratory of Biostatistics, Department of Ruminants Science, West Pomeranian University of Technology in Szczecin, Szczecin, Poland
³Laboratory of Physiological Chemistry, West Pomeranian University of Technology in Szczecin, Szczecin, Poland

The aim of this study was to relate polymorphic variants of CYP19, CYP21 and ER1 genes to reproductive traits in 472 Polish Holstein-Friesian cows. High frequencies of one of the homozygous genotypes were found. The ER1/SnaBI^AA homozygotes were not identified. In the first and third lactation, an average calving-to-conception interval (CLVC) in cows of ER1/SnaBI^GG genotype was significantly shorter (P ≤ 0.05) than in heterozygous cows. In the cows of ER1/BglI^GG genotype, significantly shorter CLVC (P ≤ 0.05) was observed compared to heterozygotes in the first lactation, whereas in the third lactation, CLVC in homozygous cows was significantly longer (P ≤ 0.05) than in heterozygous ones. It was also found that homozygous cows were characterized by significantly longer calving interval (CLVI; P ≤ 0.05) compared to heterozygotes in the third lactation. Longer CLVCs in CYP19^AA cows were found, compared to heterozygotes, and this difference was significant in the first and third lactation (P ≤ 0.05). Similarly, the average CLVIs were longer in CYP19^AA homozygotes than in heterozygous cows; however, significance was proven only in the third lactation (P ≤ 0.05). Description of the molecular mechanisms regulating reproduction, and thus identification of the individuals of genotypes with optimal potential may facilitate the employment of selected reproductive model by a breeder.