Acta Vet. Brno 2012, 81: 189-194

The effect of new probiotic strain Lactobacillus plantarum on counts of coliforms, lactobacilli and bacterial enzyme activities in rats exposed to N,N-dimethylhydrazine (chemical carcinogen)

Denisa Čokášová1, Alojz Bomba1, Ladislav Strojný1, Beata Pramuková1, Viktória Szabadosová1, Rastislav Salaj1, Jana Žofčáková1, Andrea Brandeburová1, Anna Supuková1, Alena Šoltésová1, Emília Hijová1, Júlia Ričanyová1, Leonard Siegfried2, Peter Supuka3

1Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Košice, Slovak Republic
2Institute of Medical and Clinical Microbiology, P. J. Šafárik University, Košice, Slovak Republic
3Institute of Animal Husbandry, University of Veterinary Medicine and Pharmacy, Košice, Slovak Republic


1. Berthier F, Ehrlich SD: Rapid species identification within two groups of closely related lactobacilli using PCR primers that target the 16S/23S rNA spacer region. Microb Letters 161: 97-106
2. Bertková I, Hijová E, Chmelárová A, Mojžišová G, Petrášová D, Strojný L, Bomba A, Žitňan R 2010: The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats. Neoplasma 57: 422-428 <>
3. Djouzi Z, Andrieux C 1997: Compared effect of the three oligosaccharides on metabolism of intestinal microflora on rats inoculated with a human faecal flora. Br J Nutr 78: 313-324 <>
4. Fukui M, Fujino T, Tsutsui K, Maruyama T, Yoshimura H, Shinohara T, Fukui M, Nada O 2001: The tumour-preventing effect of a mixture of several lactic acid bacteria on 1,2-dimethylhydrazine-induced colon carcinogenesis in mice. Onc Report 8: 1073-1078
5. Herich R, Kokinčáková T, Lauková A, Levkutová M 2010: Effect of preventive application of Enterococcus faecium EF55 on intestinal mucosa during salmonellosis in chickens. Cz J An Sci 55: 42-47 <>
6. Jenkins B, Holsten S, Bengmark S, Martindale R 2005: Probiotics: A practical review of their role in specific clinical scenarios. Nut Clin Prac 20: 262-270 <>
7. Juśkiewcz J, Zduńczyk Z, Wróblewska M, Oszmiański J, Hernandez T 2002: The response of rats to feeding with diets containing grapefruit flavonoid extract. Food Res Int 35: 201-205 <>
8. Kumar A, Kumar NS, Phushpalata RS 2009: Inhibition of 1,2-dimethylhydrazine induced colon genotoxicity in rats by the administration of probiotics curd. Mol Bio Rep 10: 1-4
9. Le Blanc AM, Perdigón G 2005: Reduction of beta-glucuronidase and nitro-reductase activity by yoghurt in a murine colon cancer model. Biocell Mendoza 29: 1-17
10. Lunz W, Peluzio MCG, Dias CMGC, Moreira APB, Natali AJ 2008: Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer. Braz J Med Bio Res 41: 1000-1004 <>
11. Marciňáková M, Lauková A, Simonová M, Strompfová V, Koréneková B, Naď P 2008: A new probiotic and bacteriocin-producing strain of Enterococcus faecium EF 9296 and its use in grass enciling. Cz J An Sci 53: 336-345
12. Meyerhardt JA, Niedzwiecki D, Hollis D, Saltz LB, Hu FB, Mayer RJ, Nelson H, Whittom R, Hantel A, Thomas J, Fuchs CS 2007: Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. J Am Med Ass 298: 754-764 <>
13. Moreira APB, Sabarense CM, Dias CMGC, Lunz W, Natali AJ, Glória MBA, Peluzio MCG 2009: Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1,2-dimethylhydrazine-induced colon cancer in rats. Braz J Med Bio Res 12: 1167-1172 <>
14. Nemcová R, Bomba A, Gancarčíková S, Herich R, Guba P 1999: Study of the effect of Lactobacillus paracasei and fructooligosacharides on the faecal microflora in weanling piglets. Ber Mun Tier Woch 7: 225-228
15. Rafter J 2004: The effects of probiotics on colon cancer development. Nutr Res Rev 17: 277-284 <>
16. World Health Statistics 2008: WHO Press, May 110 p.
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Indexed in DOAJ