Acta Vet. Brno 2012, 81: 275-280

Markers of oxidative and antioxidative activity in female dogs with mammary gland tumour with and without additional vitamin E supplementation

Renata Stavinohová1, Jana Lorenzová1, Ivana Papežíková2, Ivana Borkovcová3, Jakub Pfeifr1, Antonín Lojek4, Markéta Mrázová1, Michal Crha1

1University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Surgery and Orthopaedics, Dogs and Cats Clinic, Brno, Czech Republic
2University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Veterinary Ecology and Environment Protection, Brno, Czech Republic
3University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Milk Hygiene and Technology, Brno, Czech Republic
4Institute of Biophysics of the AS CR, v.v.i., Department of Free Radical Pathophysiology, Brno, Czech Republic


1. Ames BN 2004a: Delaying the mitochondrial decay of aging. Ann NY Acad Sci 1019: 406-411 <>
2. Ames BN 2004b: A role for supplements in optimizing health: the metabolic tune-up. Arch Biochem Biophys 423: 227-234 <>
3. Badwey JA, Karnovsky ML 1980: Active oxygen species and the functions of phagocytic leukocytes. Ann Rev Biochem 49: 695-726 <>
4. Brigelius FR, Kelly FJ, Salonen JT, Neuzil J, Zingg JM, Azzi A 2002: The Europen perspective on vitamin E: current knowledge and future research. Am J Clin Nutr 76: 703-716
5. Buzby GP, Mullen JL, Stein TP, Miller EE, Hobbs CL, Rosato EF 1980: Host-tumor interactions and nutrient supply. Cancer 45: 2940-2948 <<2940::AID-CNCR2820451208>3.0.CO;2-P>
6. Citová I, Havlíková L, Urbánek L, Solichová D, Nováková L, Solich P 2007: Comparison of a novel ultra-performance liquid chromatographic method for determination of retinol and alpha-tocopherol in human serum with conventional HPLC using monolithic and particulate columns. Anal Bioanal Chem 388: 675-681 <>
7. Diplock AT 1991: Antioxidant nutrients and disease prevention: an overview. Am J Clin Nutr 53: 189-193
8. Ellman GL 1959: Tissue sulfhydryl groups. Arch Biochem Biophys 82: 70-77 <>
9. Halliwell B, Gutteridge JM 1985: The importance of free radicals and catalytic metals irons in human diseases. Mol Aspects Med 8: 89-193 <>
10. Karpenko LIu, Bakhta AA, Sukhovol´skii OK 2008: Age-related characteristics of antioxidant system in healthy dogs. Adv Gerontol 21: 49-52
11. Kumaraguruparan R, Balachandran C, Manohar BM, Nagini S 2005: Altered oxidant-antioxidant profile in canine mammary tumours. Vet Res Commun 29: 287-296 <>
12. McMichael MA 2007: Oxidative stress, antioxidants and assessment of oxidative stress in dogs and cats. J Am Vet Med Assoc 231: 714-720 <>
13. Moore K, Roberts LJ 2nd 1998: Measurement of lipid peroxidation. Free Radic Res 28: 659-671 <>
14. Portakal O, Ozkawa O, Erden IM, Bozan B, Kosan M, Sayek I 2000: Coenzym Q 10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 33: 279-284 <>
15. Scott KC, Hill RC, Lewis DD, Boning AJ Jr, Sundstrom DA 2001: Effect of alpha-tocopheryl acetate supplementation on vitamin E concentrations in Greyhounds before and after a race. Am J Vet Res 62: 1118-1120 <>
16. Shen X, Tang Q, Wu J, Feng Y, Huang J, Cai W 2009: Effect of vitamin E supplementation on oxidative stress in a rat model of diet-induced obesity. Int J Vitam Nutr Res 79: 255-263 <>
17. Sies H 1993: Strategies of antioxidant defense. Eur J Biochem 215: 213-219 <>
18. Stowe HD, Lawler DF, Kealy RD 2006: Antioxidant status of pair-fed labrador retrievers is affected by diet restriction and aging. J Nutr 136: 1844-1848
19. Szczubial M, Kankofer M, Lopuszynski W, Dabrowski R, Lipko J 2004: Oxidative stress parameters in bitches with mammary gland tumours. J Vet Med A Physiol Pathol Clin Med 51: 336-340 <>
20. Tran JL, Horvath C, Krammer S, Hőller U, Zentek J 2007: Blood vitamin concentrations in privately owned dogs fed non-standardized commercial diets and after intake of diets with specified vitamin concentrations. J Anim Physiol Anim Nutr 91: 40-47 <>
21. Ying J, Clavreul N, Sethuraman M, Adachi T, Cohen RA 2007: Thiol oxidation in signaling and response to stress: detection and quantification of physiological and pathophysiological thiol modifications. Free Radic Biol Med 43: 1099-1108 <>
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