Acta Vet. Brno 2012, 81: 409-414

Effects of parenteral administration of enrofloxacin on electrocardiographic parameters in hospitalized dogs

Carlos Fernando Agudelo Ramírez1, Peter Scheer2,3, Jaroslava Tomenendálová3

1University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Internal Medicine, Clinic of Dog and Cat Diseases, Brno, Czech Republic
2St. Anne’s Hospital Brno - ICRC, Brno, Czech Republic
3University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Physiology, Brno, Czech Republic


1. Bazett HC 1920: An analysis of the time relationship of electrocardiograms. Heart 7: 353-370
2. Boothe DM, Boeckh A, Boothe HW, Wilkie S 2001: Tissue concentrations of enrofloxacin and ciprofloxacin in anesthetized dogs following single intravenous administration. Vet Therapeutics 2: 120-128
3. Chanoit GP, Schneider M, Woehrlé F, Lefebvre HP 2005: Effect of marbofloxacin on cardiovascular variables in healthy isoflurane-anesthetized dogs. Am J Vet Res 66: 2090-2094 <>
4. Dennis SG, Wotton PR, Boswood A, Flaherty D 2007: Comparison of the effects of thiopentone and propofol on the electrocardiogram of dogs. Vet Rec 160: 681-686 <>
5. Fenichel RR, Malik M, Antzelevitch C, Sanguinetti M, Roden DM, Priori SG, Ruskin JN, Flanagan MC, Mitchell ES, Haigney MC 2006: Ciprofloxacin-induced torsade de pointes. Int J Cardiol 113: 239-241
6. Fridericia LS 1920: The duration of systole in the electrocardiogram of normal subjects and of patients with heart disease. Acta Med Scand 53: 469-486 <>
7. Friedman MJ, Mull CC, Sharieff GQ, Tsarouhas N 2003: Prolonged QT syndrome in children: an uncommon but potentially fatal entity. J Emerg Med 24: 173-179 <>
8. Ghaffari MS, Parsamehr R 2009: The effects of intravenous ciprofloxacin on the electrocardiogram of healthy dogs. Vet Res Commun 33: 987-990 <>
9. Gupta A, Lawrence AT, Krishnan K, Kavinsky CJ, Trohman RG 2007: Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 153: 891-899 <>
10. Koyama H, Yoshii H, Yabu H, Kumada H, Fukuda K, Mitani S, Rousselot JF, Virose H, Uchino T 2004: Evaluation of QT interval prolongation in dogs with heart failure. J Vet Med Sci 66: 1107-1111 <>
11. Lu GC, She JH, Jiang H, Li YZ, Yuan BJ 2008: Sixty-day repeated dose toxicity of sinafloxacin in rats and dogs. Food Chem Toxicol 46: 575-580 <>
12. Moss AJ 1999: The QT interval and torsade de pointes. Drug Saf 21: 5-10 <>
13. Sagie A, Larson MG, Goldberg RJ, Bengston JR, Levy D 1992: An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol 70: 797-801 <>
14. Shah RR 2002: The significance of QT interval in drug development. Br J Clin Pharmacol 54: 188-202 <>
15. Sheridan DJ 2000: Drug-induced proarrhythmic effects: assessment of changes in QT interval. Br J Clin Pharmacol 50: 297-302 <>
16. Toyoshima S, Kanno A, Kitayama T, Sekiya K, Nakai K, Haruna M, Mino T, Miyazaki H, Yano K, Yamamoto k 2005: QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals. J Pharmacol Sci 99: 459-471 <>
17. Van de Water A, Verheyen J, Xhonneux R, Reneman RS 1989: An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. J Pharmacol Methods 22: 207-217
18. Wang J, Della Penna K, Wang H, Karczewski J, Connolly TM, Koblan TS, Bennett PB, Salata JJ 2003: Functional and pharmacological properties of canine ERG potassium channels. Am J Physiol Heart Circ Physiol 284: 256-267 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Indexed in DOAJ