Acta Vet. Brno 2013, 82: 309-316
https://doi.org/10.2754/avb201382030309
Exercise-induced pulmonary haemorrhage in horses – review
References
1. Ainsworth D, Hackett R 2004: Disorders of the respiratory system. In: Reed SM, Bayly WM, Sellon DC (eds). Equine Internal Medicine. 2nd ed. Saunders, Philadelphia, USA, pp 289-353
2. Ainsworth DM 2008: Lower airway function: responses to exercise and training. In: Equine exercise physiology: The Science of exercise in the athletic horse, Eds: KW Hinchcliff, RJ Goer and AJ Kaneps, Elsevier Saunders, New York, 193 p.
3. O, Palma P, Salvi M, Bustamante H, Vits L 2005: Endoscopic determination of exercise-induced pulmonary haemorrhage in Chilean Criollo horses. Vet J 169: 311-313
<https://doi.org/10.1016/j.tvjl.2004.02.002>
4. T, Duvivier D, Votion D, Anciaux N, Vandenput S, Bayly W, Lekeux P 1998: Does an acute COPD crisis modify the cardiorespiratory and ventilatory adjustment to exercise in horses? J Applied Physiol 84: 845-852
<https://doi.org/10.1152/jappl.1998.84.3.845>
5. T, Lekeux P 1994: Exercise induced pulmonary hemorrhage in horses: an enigma of equine medicine. Ann Méd Vét 138: 145-153
6. SL, Glenny RW, Erickson HH, Fedde MR. Polissar N, Basaraba RJ, Hlastala MP 1996: Minimal redistribution of pulmonary blood flow with exercise in racehorses. J Applied Physiol 81: 1062-1070
<https://doi.org/10.1152/jappl.1996.81.3.1062>
7. EK, Shuler KM, Soma LR, Martin BB, Marconato L, Del Piero F, Teleis DC, Schar, D, Hessinger AE, Uboh CE 2002: EIPH: postrace endoscopic evaluation of standard breeds and thoroughbreds. Equine Vet J 34: 375-378
<https://doi.org/10.1111/j.2042-3306.2002.tb05451.x>
8. Boucher J 1989: Exercise-induced echinocytosis. In: Jones WE, Equine sports medicine Philadelphia, Lea and Febiger, USA, pp 43-51
9. C, Connes P, Bouix D, Mercier J 2002: Does haemorhelogy the paradox of hipoxemia during exercise in elite athletes or thoroughbred horses. Clin Hemorheol Microcirc 26: 175-181
10. WR 2002: Bit-induced asphyxia in the horse: elevation and dorsal displacement of the soft palate at exercise. J Equine Vet Sci 22: 7-14
<https://doi.org/10.1016/S0737-0806(02)70207-4>
11. WR, Williams R, Kirker-Head C 1988: Upper airway obstruction partial asphyxia as possible cause of exercise-induced pulmonary hemorrhage in the horse: An hypothesis. Equine Vet J 8: 11-26
<https://doi.org/10.1016/S0737-0806(88)80103-5>
12. MF, Ronchi FA, Ivanow A, Carmona AK, Casarini D, Slocombe RF 2011: Association between circulating angiotensin-converting enzyme and exercise-induced pulmonary haemorrhage in thoroughbred racehorses. Res Vet Sci 93: 993-994
<https://doi.org/10.1016/j.rvsc.2011.10.011>
13. FJ, Slocombe RF, Gray PR, Robinson NE 1992: Exercise induced pulmonary hemorrage in horses with experimentally induced allergic lung disease. Am J Vet Res 53: 15-21
14. FJ, Williams KJ, Pannirselvam RR, de Feijter-Rupp H, Steel CM, Robinson NE 2009: Regional distribution of collagen and haemosiderin in the lungs of horses with exercise-induced pulmonary haemorrhage. Equine Vet J 41: 586-591
<https://doi.org/10.2746/042516409X429419>
15. F, Williams K, Stack A 2011: Exercise-induced pulmonary hemorrhage in horses: the role of pulmonary veins. Compend Contin Educ Vet 33: E1-E6
16. M, Viel L 2002: Alveolar macrophages graded hemosiderin score from bronchoalveolar lavage in horses with exercise induced pulmonary hemorrhage and controls. J Vet Intern Med 16: 281-286
<https://doi.org/10.1111/j.1939-1676.2002.tb02370.x>
17. HH 1992: Pulmonary artery and aortic pressure changes during high intensity treadmill exercise in the horse: effect of furosemide and phentolamine. Equine Vet J 23: 434-437
18. HH, Bernard SL, Glenny RW, Fedde MR, Polissar NL, Basaraba RJ, Walther SM, Gaughan EM, McMurphy R, Hlastala MP 1999: Effect of furosamide on pulmonary blood flow distribution in resting and exercising horses. J Applied Physiol 86: 2034-2043
<https://doi.org/10.1152/jappl.1999.86.6.2034>
19. TS, McDonough P, Padilla DJ, Gentile JM, Edwards KL, Erickson HH, Poole DC 2006: Exercise-induced pulmonary haemorrhage during submaximal exercise. Equine Vet J Supplement 36: 502-507
<https://doi.org/10.1111/j.2042-3306.2006.tb05595.x>
20. HH, Hildreth T, Poole DC, Cox J 2001: Management of exercise induced pulmonary hemorrhage in non racing performance horses. Compend Contin Educ Vet 23: 1090-1093
21. M, Wood S 1993: Rheological characteristics of horse blood: significance during exercise. Respir Physiol 94: 323-335
<https://doi.org/10.1016/0034-5687(93)90027-8>
22. RJ, Ommundson L, Fenton G, Pagan JD 2001: Effects of an external nasal strips and furosemide on pulmonary hemorrhage in thoroughbreds following high-intensity exercise. Equine Vet J 33: 537-539
23. TE, Manohar M, Hassan AS, Baker GJ 2001: Nasal strips do not affect pulmonary gas exchange anaerobic metabolism, or EIPH in exercising thoroughbreds. J Applied Physiol 91: 2378-2385
<https://doi.org/10.1152/jappl.2001.90.6.2378>
24. TE, Manohar M, Magid JH 1999: Repeated administration of furosemide dose not offer an advantage over single dosing in attenuating exercise-induced pulmonary hypertension in thoroughbred horses. Equine Vet J 30: 539-545
25. JD, Mundy G, Stanley S, Harrinson L, Poonacha K, Williams N, Tobin T 1997: Exercise-induced pulmonary hemorrhage: review of etiology and pathogenesis. Vet Clin North Am Equine Pract 19: 22-28
26. JD, Tobin T 1995: Racing horses, nitroglycerin and exercise induced pulmonary hemorrhage. Equine Vet J 27: 240-241
<https://doi.org/10.1111/j.2042-3306.1995.tb03069.x>
27. KW 2000: Counting red cells- is it an answer to EIPH. Equine Vet J 32: 979-984
28. KW, Jackson MA, Morley PS, Brown JA, Dredge AE, O’Callaghan PA, McCaffrey JP, Slocombe RE, Clarke AE 2005: Association between exercise-induced pulmonary hemorrhage and performance in thoroughbred racehorses. J Am Vet Med Assoc 227: 768-774
<https://doi.org/10.2460/javma.2005.227.768>
29. KW, Morley PS, Guthrie AJ 2009: Efficacy of furosemide for prevention of exercise-induced pulmonary hemorrhage in thoroughbred racehorses. J Am Vet Med Assoc 235: 76-82
<https://doi.org/10.2460/javma.235.1.76>
30. KW, Morley PS, Jackson MA, Brown JA, Dredge AF, O’Callaghan, PA, McCaffrey JP, Slocombe RF, Clarke AF 2010: Risk factors for exercise-induced pulmonary haemorrhage in thoroughbred racehorses. Equine Vet J supplement 38: 228-234
<https://doi.org/10.1111/j.2042-3306.2010.00245.x>
31. I, Meyer MR, Erickson HH 2000: Relationship of pulmonary arterial pressure to pulmonary hemorrhage in exercise horses. Equine Vet J 32: 379-384
<https://doi.org/10.2746/042516400777591066>
32. I, Weigle GE, Erickson HH, Fedde MR 1999: Influence of furosamide on dynamic cardiac variables during exercise. Equine Vet J 30: 170-173
33. JM, Vrins A, McCarvill E 1994: A survey of exercise-induced pulmonary hemorrhage in Quebec standard breeds racehorses. Equine Vet J 6: 482-485
<https://doi.org/10.1111/j.2042-3306.1994.tb04054.x>
34. Markham G 1688: Markham’s master-piece revived: Containing all knowledge belonging to the Smith, FUFFieF of horse-leach. London: John Richardson for Tho. Passinger. p. 184
35. SA, Canfield PJ, Rose RJ 1993: Equine bronchoalveolar lavage cytology: survey of thoroughbred racehorse in training. Australian Vet J 70: 401-404
<https://doi.org/10.1111/j.1751-0813.1993.tb06072.x>
36. SA, Slocombe RF 2002: Alveolar fibrosis and changes in equine lung morphometry in response to intrapulmonary blood. Equine Vet J supplement 34: 451-458
<https://doi.org/10.1111/j.2042-3306.2002.tb05465.x>
37. M 1994: Pulmonary vascular pressures of thorougbreds increase rapidly and to higher level with rapid onset of high-intensity exercise than slow onset. Equine Vet J 26: 496-499
<https://doi.org/10.1111/j.2042-3306.1994.tb04057.x>
38. M, Goetz TE, Hassan AS 2001: Effect of prior high-intensity exercise on exercise-induced arterial hypoxemia in thoroughbred horses. J Applied Physiol 90: 2371-2377
<https://doi.org/10.1152/jappl.2001.90.6.2371>
39. M, Goetz TE, Rothenbaum P, Humphrey S 2000: Clenbuterol administration does not enhance the efficacy of furosemide in attenuating the exercise-induced pulmonary capillary hypertension in thoroughbred horses. J Vet Pharmacol Ther 23: 389-395
<https://doi.org/10.1046/j.1365-2885.2000.00293.x>
40. M, Hutchens E, Coney E 1993: Pulmonary hemodynamics in the exercising horses and their relationship to exercise-induce pulmonary hemorrhage. Br Vet J 149: 419-428
<https://doi.org/10.1016/S0007-1935(05)80108-3>
41. PV Jr, Muehlmann LA, Zanatta AL, Bieberbach EW, Kryczyk M, Fernandes LC, Nishiyama A 2011: Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in thoroughbred colts during race training. Vet J 190: e3-6
<https://doi.org/10.1016/j.tvjl.2010.08.009>
42. G, Carrillo R, Campos B, Garcia C 2003: Endoscopic evaluation of exercise induced pulmonary hemorrhage in polo ponies. Arch Med Vet 35: 109-113
43. JR, Rogers K, Marlin DJ, Wood JL, Williams RB 2005: Risk factors for epistaxis on British racecourses: evidence for locomotory impact-induced trauma contributing to the aetiology of exercise-induced pulmonary haemorrhage. Equine Vet J 37: 402-411
<https://doi.org/10.2746/042516405774480049>
44. J, Wood J 2002: Evidence of an association between inflammatory airway disease and EIPH in young thoroughbreds during training. Equine Vet J 34: 417-424
<https://doi.org/10.1111/j.2042-3306.2002.tb05459.x>
45. MW, Hornof WJ, Fisher PE, Pascoe JR 1987: Exercise-induced pulmonary hemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. VII. Ventilation/perfusion scintigraphy in horses with EIPH. Equine Vet J 19: 423-427
<https://doi.org/10.1111/j.2042-3306.1987.tb02635.x>
46. M 1999: Exercise induced hemorrhage lesions in the dorsocaudal extremities of the caudal lobes of the lungs of young thoroughbred horses. J Comp Pathol 121: 339-347
<https://doi.org/10.1053/jcpa.1999.0331>
47. Pascoe JR 1996: Exercise-induced pulmonary hemorrhage: unifying concept. In Proceeding. 42nd Annual American Association of Equine Practitioner Convention, p 220-226
48. Pascoe JR 1997: Exercise-induced pulmonar. In: Robinson NE. Current therapy in equine medicine. 4nd ed. Saunders, Philadelphia, USA, p 441-443
49. JR, McCabe AE, Franti CE, Arthur RM 1981: Efficacy of furosemide in the treatment of exercise-induced pulmonary hemorrhage in thoroughbred racehorses. Am J Vet Res 42: 703-707
50. DC, Epp TS, Erickson HH 2007: Exercise-induced pulmonary haemorrhage (EIPH): mechanistic bases and therapeutic interventions. Equine Vet J 39: 292-293
<https://doi.org/10.2746/042516407X204078>
51. JB 1913: The heredity of blood-vessel breaking in the thoroughbred. Bloodstock Breeders’ Rev 2: 265-281
52. RC, Leeming A, Denny E, Bharath A Marlin DJ 1999: Modelling impact-initiated wave transmission through lung parenchyma in relation to the etiology of exercise-induced pulmonary hemorrhage. Equine Vet J Supplement 30: 34-38
53. RC, Marlin DJ, Denny E 1998: Exercise induced hemorrhage pulmonary (EIPH) in horses results from locomotory impact induced trauma novel, unifying concept. Equine Vet J 30: 186-192
<https://doi.org/10.1111/j.2042-3306.1998.tb04486.x>
54. LR, Birks EK, Uboh CE, May L, Teleis D, Martini J 2000: The effects of furosemide on racing time of Standardbred pacers. Equine Vet J 32: 334-340
<https://doi.org/10.2746/042516400777032264>
55. LR, Uboh CE 1998: Review of furosemide in horses racing: its effects and regulation. J Vet Pharmacol Ther 21: 228-240
<https://doi.org/10.1046/j.1365-2885.1998.00132.x>
56. C 1991: Exercise-induced pulmonary hemorrhage. Vet Clin North Am Equine Pract 7: 93-104
<https://doi.org/10.1016/S0749-0739(17)30518-7>
57. T, Hiraga A, Ohmura H, Kai M, Jones JH 2001: Frequency of and risk factors for epistaxis associated with exercise induced pulmonary hemorrhage in horse. J Am Vet Med Assoc 218: 1462-1464
<https://doi.org/10.2460/javma.2001.218.1462>
58. JB, Mathieu-Costello O 1994: Stress failure of pulmonary capillaries as a mechanism for exercise induced pulmonary hemorrhage in the horse. Equine Vet J 26: 441-447
<https://doi.org/10.1111/j.2042-3306.1994.tb04047.x>
59. JB, Mathieu-Costello O 1995: Stress failure of pulmonary capillaries as limiting factor for maximal exercise. Eur J Appl Physiol 70: 99-108
<https://doi.org/10.1007/BF00361536>
60. JB, Mathieu-Costello O 1998: Stress-induced injury of pulmonary capillaries. Proc Assoc Am Physicians 110: 506-512
61. JB, Mathieu-Costello O, Jones JH, Birks EK, Logemann RB, Pascoe JR, Tyler WS 1993: Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. J Applied Physiol 75: 1097-109
<https://doi.org/10.1152/jappl.1993.75.3.1097>
62. DJ, Geor RJ, Smith CM Jr 1994: Effects of echinocytosis on hemorrheologic values and exercise performance in horses. Am J Vet Res 55: 204-210
63. DJ, Smith CM Jr 1998: Haemorrheogical alterations associated with competitive racing activity in horses: implications for exercise-induce pulmonary hemorrhage (EIPH). Equine Vet J 30: 7-12
<https://doi.org/10.1111/j.2042-3306.1998.tb04082.x>
64. KJ, Derksen FJ, de Feijter-Rupp H, Pannirselvam RR, Steel CM, Robinson, NE 2008: Regional pulmonary veno-occlusion: a newly identified lesion of equine exercise-induced pulmonary hemorrhage. Vet Pathol 45: 316-326
<https://doi.org/10.1354/vp.45-3-316>
