Acta Vet. Brno 2013, 82: 337-342

Duodenal morphology and immune responses of broiler chickens fed low doses of deoxynivalenol

Viera Revajová1, Zuzana Slaminková1, Ľubomíra Grešáková2, Mikuláš Levkut1

1University of Veterinary Medicine and Pharmacy, Department of Pathological Anatomy, Košice, Slovak Republic
2Institute of Animal Physiology, Slovak Academy of Sciences, Košice, Slovak Republic


1. Awad WA, Böhm J, Razzazi-Fazeli E, Zentek J 2006: Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens. J Anim Physiol Anim Nutr 90: 32-37 <>
2. Awad WA, Ghareeb K, Böhm J, Razzazi E, Hellweg P, Zentek J 2008: The impact of the Fusarium toxin deoxynivalenol (DON) on poultry. Int J Poult Sci 7: 827-842 <>
3. Brown CC, Baker DC, Barker IK 2008: Immune elements and the gastrointestinal mucosal barrier. In Maxie MG (Ed.), Jubb, Kennedy, and Palmer`s Pathology of domestic animals. Fifth edition, volume 2. Saunders Elsevier, London, pp. 72-75
4. Canady RA, Coker RD, Egan SK, Krska R, Kuiper-Goodman, Olsen TM, Pestka J, Resnik S, Schlatter J 2002: Evaluation of certain mycotoxins in food. Fifty-sixth report of the Joint FAO/WHO expert committee on food additives (JECFA) Deoxynivalenol World Health Organ Tech Rep Ser 906: 1-62
5. Dänicke S, Ueberschär KH, Halle I, Matthes S, Valenta H, Flachowsky G 2002: Effect of addition of a detoxifying agent to laying hen diets containing uncontaminated or Fusarium toxin-contaminated maize on performance of hens and on carryover of zearalenone. Poult Sci 81: 1671-1680 <>
6. Davison F, Kaspers B, Schat KA 2008. Avian Immunology. First edition, Academic Press, Elsevier, London, p. 243-249
7. D'Mello JPF, Placinta CM, Macdonald AMC 1999: Fusarium mycotoxins: a review of global implications for animal health, welfare and productivity. Anim Feed Sci Technol 80: 183-205 <>
8. Labuda R, Tancinova D, Hudec K 2003: Identification and enumeration of Fusarium species in poultry feed mixtures from Slovakia. Ann Agric Environ Med 10: 61-66
9. Levkut M, Pistl J, Lauková A, Revajová V, Herich R, Ševčíková Z, Strompfová V, Szabóová R, Kokinčáková T 2009: Antimicrobial activity of Enterococcus faecium EF 55 against Salmonella enteritidis in chicks. Acta Vet Hung 57: 13-24 <>
10. Levkut M, Revajová V, Slaminková Z, Levkutová M, Bořutová R, Grešáková L, Leng L 2011: Lymphocyte subpopulations in blood and duodenal epithelium of broilers fed diets contaminated with deoxynivalenol and zearalenone. Anim Feed Sci Technol 165: 210-217 <>
11. Onai N, Kitabatake M, Zhang YY, Ishikawa H, Ishikawa S, Matsushima K 2002: Pivotal role of CCL25 (TECK)-CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes. Int Immunol 14: 687-694 <>
12. Oswald IP, Marin DE, Bouhet S, Pinton P, Taranu I, Accensi F 2005: Immunotoxicological risk of mycotoxin for domestic animals. Food Addit Contam Part A 22: 354-360 <>
13. Pestka JJ 2003: Deoxynivalenol-induced IgA production and IgA nephropathy-aberrant mucosal immune response with systemic repercussions. Toxicol Lett 140-141: 287-295 <>
14. Pestka JJ, Zhou H-R, Moon Y, Chung YJ 2004: Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicol Lett 153: 61-73 <>
15. Raymond SL, Smith KT, Swamy HVLN 2003: Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on feed intake, serum chemistry, and hematology of horses, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J Anim Sci 81: 2123-2130 <>
16. Sergent T, Parys M, Garsou S, Pussemier L, Schneider YJ, Larondelle Y 2006: Deoxynivalenol transport across human intestinal Caco-2 cells and its effects on cellular metabolism at realistic intestinal concentration. Toxicol Lett 164: 167-176 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue