Acta Vet. Brno 2015, 84: 55-62

https://doi.org/10.2754/avb201585010055

The effect of alkaloids present in blue lupine (Lupinus angustifolius) seeds on the growth rate, selected biochemical blood indicators and histopathological changes in the liver of rats

Maria Stanek1, Tadeusz Rotkiewicz2, Wiesław Sobotka1, Jacek Bogusz1, Iwona Otrocka-Domagała2, Agnieszka Rotkiewicz3

1University of Warmia and Mazury in Olsztyn, Faculty of Animal Bioengineering, Department of Animal Nutrition and Fodder Science, Olsztyn, Poland
2University of Warmia and Mazury in Olsztyn, Faculty of Veterinary Medicine, Department of Pathological Anatomy, Olsztyn, Poland
3University of Warmia and Mazury in Olsztyn, Faculty of Law and Administration, Department of Administrative Procedure and Administrative Court Proceedings, Olsztyn, Poland

Received February 14, 2014
Accepted October 22, 2014

References

1. Bañuelos Pineda J, Nolasco Rodríguez G, Monteon JA, García López PM, Ruiz Lopez MA, García Estrada J 2005: Histological evaluation of brain damage caused by crude quinolizidine alkaloid extracts from lupines. Histol Histopathol 20: 1147-1153
2. Birk Y 1993: Antinutritional factors ANFs in lupin and in other legume seeds: pros and cons. In: Proceedings of the 7th International Lupin Conference, Evora, Portugal, pp. 424–429
3. Butler WH, Ford GP, Creasy DM 1996: A 90-day feeding study of lupin (Lupinus angustifolius) flour spiked with lupin alkaloids in the rat. Food Chem Toxicol 34: 531-536 <https://doi.org/10.1016/0278-6915(96)00025-7>
4. Close B, Banister K, Baumas V, Bernoth EM, Bromage N, Bunyan J, Erhardt W, Flecknell P, Gregory N, Hackbarth H, Morton D, Warwick C 1997: Recommendations for euthanasia of experimental animals. Part 2. Lab Animals 31: 1-32 <https://doi.org/10.1258/002367797780600297>
5. Crepon K, Marget P, Peyronnet C, Carrouee B, Arese P, Duc G 2010: Nutritional value of faba bean (Vicia faba L.) seeds for feed and food. Field Crop Res 115: 329-339 <https://doi.org/10.1016/j.fcr.2009.09.016>
6. De Cortes-Sánchez M, Altares P, Pedrosa MM, Burbano C, Cuadrado C, Goyoaga C, Muzquiz M, Jiménez-Martínez C, Dávila-Ortiz G 2005: Alkaloid variation during germination in different lupin species. Food Chem 90: 347-355 <https://doi.org/10.1016/j.foodchem.2004.04.008>
7. Directive 2010/63/EU of the European Parliament and of the Council of September 2010 on the protection of animals used for scientific purposes. Official Journal of the European Union, OJ L 276, 2010, p. 33-79
8. Gdala J, Buraczewska L 1996: Chemical composition and carbohydrate content of seeds from several lupin species. J Anim Feed Sci 5: 403-416
9. Hedemann M S, Eskildsen M, Lærke HN, Pedersen C, Lindberg J E, Laurinen P, Bach Knudsen K E 2006: Intestinal morphology and enzymatic activity in newly weaned pigs fed contrasting fiber concentrations and fiber properties. J Anim Sci 84: 1375-1386 <https://doi.org/10.2527/jas.2005-701>
10. Juśkiewicz J, Godycka-Kłos I, Matusevicius P, Zduńczyk Z, Juśkiewicz M 2006: Influence of pea and lupin oligosaccharides on caecal short-chain fatty acids production and nitrogen excretion patterns in rats. Pol J Food Nutr Sci 1:77-82
11. Lampart-Szczapa E, Łoza A 2007: Functional components of lupine seeds – opportunities and potential threats (in Polish). Zeszyty Problemowe Postępów Nauk Rolniczych 522: 387-392
12. Liberati TA, Sansone SR, Feuston MH 2004: Hematology and clinical chemistry values in pregnant Wistar Hannover rats compared with nonmated controls. Vet Clin Pathol 33: 68-73 <https://doi.org/10.1111/j.1939-165X.2004.tb00352.x>
13. Madej J A, Rotkiewicz T 2006: General Veterinary Pathology (in Polish). University of Warmia and Mazury, Olsztyn, 412 p.
14. Maknickiene Z, Asakaviciute R, Baksiene E, Razukas A 2013: Alkaloid content variations in Lupinus luteus L. and Lupinus angustifolius L. Arch Biol Sci Belgrade 65: 107-112
15. National Research Council 1995: Nutrient Requirements of Laboratory Animals, 4th edn. National Academy Press, Washington, DC, 176 p.
16. Rahman MH 2005: Hypocholesterolemic activity of lupin proteins – A serendipitous discovery, In: Optimised processes for preparing healthy and added value food ingredients from lupin kernels, the European protein-rich grain legume. Proceedings of the Final Conference of the European Project, Milan, 9-10 November 2005, pp. 199-202
17. Robbins MC, Petterson DS, Brantom PG 1996: A 90-day feeding study of the alkaloids of Lupinus angustifolius in the rat. Food Chem Toxicol 34: 679-686 <https://doi.org/10.1016/0278-6915(96)00040-3>
18. Rotkiewicz T 2004: Pathomorphology of animal cells and tissues (in Polish). University of Warmia and Mazury, Olsztyn, 200 p.
19. Rotkiewicz T, Stanek M, Wiśniewska M, Otrocka-Domagała I, Bogusz J, Purwin C, Bomba G 2007: Pathomorphological and histochemical examinations of the digestive tracts and some internal organs of pigs fed diets containing narrow-leaved lupin (Lupinus angustifolius) seeds. Ann Anim Sci 7: 83-88
20. Saini HS 1989: Legume seed oligosaccharides. In: Huisman J, van der Poel TFB, Liner JE (Eds): Recent advances of research in antinutritional factors in legume seeds. Pudoc, Wageningen, pp. 329-341
21. Sobotka W, Stanek M, Bogusz J, Matusevicius P 2013: The effect of oligosaccharides and alkaloids contained in yellow and blue lupine seeds on feed intake, body weight and fermentation processes in the cecum of rats. Vet Zootech-Lith 63: 63-70
22. Stanek M, Bogusz J, Sobotka W, Bieniaszewski T 2006: Nutritive value of new varieties of yellow lupine (Lupinus luteus) and narrow-leaved lupine (Lupinus angustifolius). Ann Anim Sci 2/1: 206-210
23. Stanek M, Bogusz J, Sobotka W, Bieniaszewski T 2012: Nutritional value of blue lupine seeds (in Polish). Fragm Agron 29: 160-166
24. Zawistowski S 1975: Histological technique, histology and fundamentals of histopathology (in Polish). State Beetingmedical Publications, Warszawa 518 p.
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Archive