Acta Vet. Brno 2015, 84: 181-185

Anaesthetic effects of tiletamine-zolazepam-xylazine-tramadol combination in cats undergoing surgical sterilization

Lin Li1, Jing Dong1, Jianbin He1, Jixian Cui2, Xuewu Yu2, Dezhan Tan3, Honggang Fan4

1Shenyang Agricultural University, College of Animal Husbandry and Veterinary Medicine, Shenyang, China
2Institute of Animal Medical Research, Animal Disease Prevention and Control Center of Liaoning Province, Shenyang, China
3Shaoyang Vocational and Technical College, Shaoyang, China
4Northeast Agricultural University, College of Veterinary Medicine, Harbin, China

Received July 23, 2014
Accepted January 14, 2015


1. Alexis MC, Francis JG, Lisa AC, Lindsay WM, Julie KL 2004: Anesthetic and physiologic effects of tiletamine, zolazepam, ketamine, and xylazine combination (TKX) in feral cats undergoing surgical sterilization. J Feline Med Surg 6: 297-303
2. Bednarski RM, Muir WW, Tracy CH 1989: Effects of tolazoline, doxapram, and RO15-1788 on the depressant action of tiletamine/zolazepam. Vet Med 84: 1016-1022
3. Degerfeld MM 2005: Personal experiences in the use of Zoletil® for anesthesia of the red-necked wallaby (Macropus rufogriseus). Vet Res Commun 29: 297-300 <>
4. Doherty TJ 1988: Physiologic effects of alpha 2-adrenergic receptors. J Am Vet Med A 192: 1612-1614
5. Engelhardt T, Steel E, Johnston G 2003: Tramadol for pain relief in children undergoing tonsillectomy: a comparison with morphine. Paediatr Anaesth 13: 249-252 <>
6. Hellyer P, Muir W, Hubbell JA 1988: Cardiorespiratory effects of the intravenous administration of tiletamine-zolazepam to cats. Vet Surg 17:105-110 <>
7. James SB, Cook RA, Raphael BL 1999: Immobilization of babirusa (Babyrousa babyrussa) with xylazine and tiletamine/zolazepam and reversal with yohimbine and flumazenil. J Zoo Wildl Med 30: 521-525
8. Lehmann KA 1997: Tramadol in acute pain. Drugs 53: 25-33 <>
9. Lemke KA 2004: Perioperative use of selective ╬▒-2 agonists and antagonists in small animals. Can Vet J 45: 475-480
10. Lin HC, Thurmon JC, Benson GJ 1993: Telazol - a review of its pharmacology and use in veterinary medicine. J Vet Pharmacol Ther 16: 383-418 <>
11. Lin Li, Jing Dong, Dezhang Lu, Sheng Jing, Dongqi Lin, Honggang Fan 2012: Effects of leamine zolazepam xylazine tramadol combination on biochemial and haematologial Parmeters in Cats. Bull Vet Inst Pulawy 56: 369-372
12. Safarinejad MR, Hosseini SY 2006: Safety and efficacy of tramadol in the treatment of idiopathic detrusor overactivity: a double-blind, placebo-controlled, randomized study. Br J Clin Pharmacol 61: 456-463 <>
13. Shilo Y, Britzi M, Eytan B 2008: Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. J Vet Pharmacol Ther 31: 60-65 <>
14. Sousa AB, Santos ACD, Schramm SG 2008: Pharmacokinetics of tramadol and O-desmethyltramadol in goats after intravenous and oral administration. J Vet Pharmacol Ther 31:45-51
15. Witte JD, Schoenmaekers B, Sessler DL 2001: The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron. Anesth Analg 92: 1319-1321 <>
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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