Acta Vet. Brno 2015, 84: 197-207

The effect of dietary fatty acid composition on the hepatic fatty acid content and plasma lipid profile in rats

Tomáš Komprda1, Veronika Rozíková1, Barbora Němcová1, Branislav Ruttkay-Nedecký2

1Mendel University in Brno, Department of Food Technology, Czech Republic
2Mendel University in Brno, Department of Chemistry and Biochemistry, Czech Republic

Received September 3, 2014
Accepted January 14, 2015


1. Campioli E, Rustichelli C, Avallone R 2012: N-3 dietary supplementation and lipid metabolism: differences between vegetable- and fish-derived oils. J Funct Foods 4: 207-212 <>
2. Chen J, Jiang Y, Ma KY, Chen F, Chen ZY 2011: Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor, and HMG-CoA reductase. J Agr Food Chem 59: 6790-6797 <>
3. Czech National Council Act No 246/1992 Coll. on the protection of animals against cruelty, as amended by Act No 162/1993 Coll., Act No 193/1994 Coll., Act No 243/1997 Coll., finding of the Constitutional Court No 30/1998 Coll., Act No 77/2004 Coll., Act No 413/2005 Coll., Act No 77/2006 Coll. and Act No 312/2008 Coll. Prague, 2008
4. Eslick GD, Howe PRC, Smith C, Priest R, Bensoussan A 2009: Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis. Int J Cardiol 136: 4-16 <>
5. Fattore E, Bosetti C, Brighenti F, Agostoni C, Fattore G 2014: Palm oil and blood lipid-related markers of cardiovascular disease: a systematic review and meta-analysis of dietary intervention trials. Am J Clin Nutr 99: 1331-1350 <>
6. Ferramosca A, Conte L, Zara V 2012: A krill oil supplemented diet reduces the activities of the mitochondrial tricarboxylate carrier and of the cytosolic lipogenic enzymes in rats. J Anim Physiol Anim Nutr 96: 295-306 <>
7. Jacobson TA, Glickstein SB, Rowe JD, Soni PN 2012: Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: A review. J Clin Lipidol 6: 5-18 <>
8. Komprda T 2012: Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review. J Funct Foods 4: 25-38 <>
9. Komprda T, Zorníková G, Knoll A, Vykoukalová Z, Rozíková V, Škultéty O, Krobot R 2014: Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level. Czech J Anim Sci 59: 391-398 <>
10. Komprda T, Zorníková G, Rozíková V, Borkovcová M, Przywarová A 2013: The effect of dietary Salvia hispanica seed on the content of n-3 long-chain polyunsaturated fatty acids in tissues of selected animal species, including edible insects. J Food Comp Anal 32: 36-43 <>
11. König B, Koch A, Spielmann J, Hilgenfeld C, Stangl GI, Eder K 2007: Activation of PPARα lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2. Biochem Pharmacol 73: 574-585 <>
12. Lu J, Borthwick F, Hassanali Z, Wang Y, Mangat R, Ruth M, Shi D, Jaeschke A, Russel JC, Field CJ, Proctor SD, Vine DF 2011: Chronic dietary n-3 PUFA intervention improves dislipidaemia and subsequent cardiovascular complications in the JSR:LA-cp rat model of the metabolic syndrome. Brit J Nutr 105: 1572-1582 <>
13. Mozaffarian D, Wu JH 2011: Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol 58: 2047-2067 <>
14. Ooi EMM, Ng TWK, Watts GF, Barrett PHR 2013: Dietary fatty acids and lipoprotein metabolism: new insights and updates. Curr Opin Lipidol 24: 192-197 <>
15. Popović T, Borozan S, Arsić A, Debeljak-Martačić J, Vučić V, de Luka S, Milovanović I, Trbović A, Glibetić M 2011: Effects of n-3 supplementation on plasma and liver phospholipid fatty acids profile in aged Wistar rats. Croat Chem Acta 84: 73-79 <>
16. Poudyal H, Kumar SA, Iyer A, Waanders J, Ward LC, Brown L 2013: Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. J Nutr Biochem 24: 1381-1392 <>
17. Takahashi Y 2011: Soy protein and fish oil independently decrease serum lipid concentrations but interactively reduce hepatic enzymatic activity and gene expression involved in fatty acid synthesis in rats. J Nutr Sci Vitaminol 57: 56-64 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Indexed in DOAJ