Acta Vet. Brno 2015, 84: 337-342

Correlation between the cocaine- and amphetamine-regulated transcript in the pyloric section of the abomasum and fat deposition in bulls’ carcasses

Krzysztof Młynek1, Izabela Janiuk2, Adam Oler3, Marcin Maj1, Lidia Borkowska4

1Siedlce University of Natural Science and Humanistes, Department of Cattle Breeding and Milk Evaluation, Siedlce, Poland
2Department of Vertebrate Morphology, Siedlce, Poland
3University of Technology and Life Sciences, Department of Cattle Breeding, Bydgoszcz, Poland
4Siedlce University of Natural Science and Humanistes, Department of Biology, Siedlce, Poland

Received July 21, 2014
Accepted June 24, 2015


1. Aja S, Sahandy S, Ladenheim EE, Schwartz GJ, Moran TH 2001: Intracerebroventricular CART peptide reduces food intake and alters motor behavior rat a hindbrain site. Am J Physiol 281: 1862-1867
2. Arciszewski MB, Barabasz S, Skobowiat C, Maksymowicz W, Majewski M 2009: Immunodetection of cocaine- and amphetamine-regulated transcript in the rumen, reticulum, omasum and abomasum of the sheep. Anat Histol Embryol 38: 62-67 <>
3. Asnicar MA, Smith DP, Yang DD, Heiman ML, Fox N, Chen YF, Hsiung HM 2001: Absence of cocaine- and amphetamine regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology 142: 4394-4400 <>
4. Banke E, Riva M, Shcherbina L, Wierup N, Degerman E 2013: Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis. Regul Pept 182: 35-40 <>
5. Baranowska B, Wolińska-Witort E, Martynska L, Chmielowska M, Baranowska-Bik A 2004: Effects of cocaine- amphetamine regulated transcript CART on hormone release. Regul Pept 122: 55-59 <>
6. Douglass J, McKinzie AA, Couceyro P 1995: PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 15: 2471-2481 <>
7. Herman GE, Elfont EA 1991: The taming of immunohistochemistry: the new era of quality control. Biotech Histochem 66: 194-199 <>
8. Hunter RG, Philpot K, Vicentic A, Dominguez G, Hubert GW, Kuhar MJ 2004: CART in feeding and obesity. Trends Endocrinol Metab 15: 454-459 <>
9. IZ-INRA 2001: IZ-INRA: Standards of cattle, sheep and goat nutrition. National Research Institute of Animal Production, Krakow, Poland. Developed by INRA 1988
10. Janiuk I, Młynek K, Wysocki J 2013: Identification and location of the cocaine and amphetamine regulated transcript (CART) in the abomasum of cattle. Acta Histochem 115: 371-375 <>
11. Kasacka I, Piotrowska Z 2012: Evaluation of density and distribution of CART-immunoreactive structures in gastrointestinal tract of hypertensive rats. Biofactors 38: 407-415 <>
12. Kobayashi Y, Jimenez-Krassel F, Ireland JJ, Smith GW 2006: Evidence of a local negative role for cocaine and amphetamine regulated transcript (CART), inhibits and low molecular weight insulin like growth factor binding proteins in regulation of granulose cell estradiol production during follicular waves in cattle. Rep Biol Endocrin 4: 22 <>
13. Kong WM, Stanley S, Gardiner J, Abbott C, Murphy K, Seth A 2003: A role for arcuate cocaine and amphetamine regulated transcript in hyperphagia, thermogenesis, and cold adaptation. FASEB J 17: 1688-1690 <>
14. Koylu EO, Couceyro PR, Lambert PD, Ling NC, DeSouza EB, Kuhar MJ 1997: Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocrinol 9: 823-833 <>
15. Larsen PJ, Vrang N, Petersen PC, Kristensen P 2000: Chronic intracerebroventricular administration of recombinant CART (42–89) peptide inhibits and causes weight loss in lean and obese Zucker (fa/fa) rats. Obes Res 8: 590-596 <>
16. Larsen PJ, Vrang N, Tang-Christensen M, Jensen PB, Hay-Schmidt A, Romer J 2002: Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides. Eur J Pharmacol 440: 159-172 <>
17. Lucidi P, Murdolo G, Di Loreto C, Parlanti N, De Cicco A, Fatone C 2005: Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrations. Nutr Metab Cardiovasc Dis 15: 410-407 <>
18. Méndez-Díaz M, Domínguez Martín E, Pérez Morales M, Ruiz-Contreras AE, Navarro L, Prospéro-García O 2009: The anorexigenic peptide cocaine-and-amphetamine-regulated transcript modulates rem-sleep in rats. Neuropeptides 43: 499-505 <>
19. Młynek K, Janiuk I 2013: Detection of cocaine and amphetamine regulated transcript in the abomasum of slaughtered bulls with different daily body weight gains. Acta Vet Brno 82: 253-257 <>
20. Okumura T, Yamada H, Motomura W, Kohgo Y 2000: Cocaine amphetamine regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin- releasing factor system. Endocrinology 141: 2854-2860 <>
21. Qing K, Chen Y 2007: Central CART gene delivery by recombinant AAV vector attenuates body weight gain in diet-induced-obese rats. Regul Pept 140: 21-26 <>
22. Rohner-Jeanrenaud F, Craft LS, Bridwell J, Suter TM, Tinsley FC, Smiley DL, Burkhart DR, Statnick MA, Heiman ML, Ravussin E 2002: Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55–102): effects on body weight homeostasis in lean and high-fat-fed obese rats. Int. J Obes Relat Metab Disord 26:143-149 <>
23. Smith GW, Sen A, Folger JK, Ireland JJ 2010: Putative role of cocaine- and amphetamine-regulated transcript (CART-PT) in dominant follicle selection in cattle. Soc Reprod Fertil Suppl 67: 105-117
24. Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL 2003: Is the energy homeostasis system inherently biased toward weight gain? Diabetes 52: 232-238 <>
25. Thim L, Kristensen P, Nielsen PF, Wulff BS, Clausen JT 1999: Tissue-specific processing of cocaine- and amphetamine-regulated transcript peptides in the rat. Proc Natl Acad Sci 96: 2722-2727 <>
26. Valassi E, Scacchi M, Cavagnini F 2008: Neuroendocrine control of food intake. Nutr Metab Cardiovasc Dis 18:158-168 <>
27. Vettor R, Fabris R, Pagano C, Federspil G 2002: Neuroendocrine regulation of eating behavior. J Endocrinol Invest 25: 836-854 <>
28. Vrang N 2006: Anatomy of hypothalamic CART neurons. Peptides 27: 1970-1980 <>
29. Wierup N, Gunnarsdo A, Ekblad E, Sundler F 2007: Characterisation of CART-containing neurons and cells in the porcine pancreas, gastro-intestinal tract, adrenal and thyroid glands. BMC Neurosci 8: 51 <>
30. Wierup N, Kuhar MJ, Nilsson BO, Mulder H, Ekblad E, Sundler F 2004: Cocaine- and amphetamine regulated transcript (CART) is expressed in several islet cell types during rat development. J Histochem Cytochem 52: 169-177 <>
31. Wierup N, Richards WG, Bannon AW, Kuhar MJ, Ahren B, Sundler F 2005: CART knockout mice have impaired insulin secretion and glucose intolerance, altered betacell morphology and increased body weight. Regul Pept 129: 203-211 <>
32. Wortley KE, Chang GQ, Davydova Z, Fried SK, Leibowitz SF 2004: Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet. Regul Pept 117: 89-99 <>
33. Yang SC, Shie KR, Li HY 2005: Cocaine and amphetamine-regulated transcript in the nucleus accumbens participates in the regulation of feeding behavior in rats. Neuroscience 133: 841-851 <>
34. Zhang CL, Chen H, Wang YH, Lan XY, Lei CZ, Fang XT 2008: The polymorphisms of bovine cocaine- and amphetamine-regulated transcripts and their associations with cattle (Bos taurus) growth traits. J Biosci 33: 365-370 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Indexed in DOAJ