New semi-spherical radiofrequency energy device for liver resection: an experimental study in pigs

Vávra, Petr; Škrobánková, Martina; Grepl, Jan; Crha, Michal; Penhaker, Marek; Jurčíková, Jana; Škorič, Miša; Raušer, Petr; Ostruszka, Petr; Ihnát, Peter; Delongová, Patricie; Dvořáčková, Jana; Procházka, Václav; Šalounová, Dana; Habib, Nagy; Zonča, Pavel

doi:10.2754/avb201584040397

Acta Veterinaria > Archive > 2015, Vol. 84 > Issue 4 > New semi-spherical radiofrequency energy…

Acta Vet. Brno 2015, 84: 397-401

https://doi.org/10.2754/avb201584040397

New semi-spherical radiofrequency energy device for liver resection: an experimental study in pigs

Petr Vávra^1,2,3,4, Martina Škrobánková⁴, Jan Grepl⁵, Michal Crha⁶, Marek Penhaker², Jana Jurčíková⁷, Miša Škorič⁸, Petr Raušer⁹, Petr Ostruszka³, Peter Ihnát^3,4, Patricie Delongová^10,11, Jana Dvořáčková^10,11, Václav Procházka⁷, Dana Šalounová¹², Nagy Habib¹, Pavel Zonča^3,4

¹Hammersmith Hospital, Imperial College London, Liver and Pancreas Surgery, London, United Kingdom
²Technical University of Ostrava, Faculty of Electrical Engineering and Computer Science, Department of Cybernetics and Biomedical Engineering, Ostrava, Czech Republic
³University Hospital Ostrava, Department of Surgery, Ostrava, Czech Republic
⁴University of Ostrava, Faculty of Medicine, Department of Surgery, Ostrava, Czech Republic
⁵Technical University of Ostrava, Faculty of Mechanical Engineering, Ostrava, Czech Republic
⁶University of Veterinary and Pharmaceutical Sciences Brno, CEITEC VFU, Brno, Czech Republic
⁷University Hospital Ostrava, Department of Vice-President for Science and Research, Ostrava, Czech Republic
⁸University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Pathological Morphology and Parasitology, Brno, Czech Republic
⁹University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Surgery and Orthopaedics, Small Animal Clinic, Brno, Czech Republic
¹⁰University Hospital Ostrava, Institute of Pathology, Ostrava, Czech Republic
¹¹University of Ostrava, Faculty of Medicine, Institute of Pathology, Ostrava, Czech Republic
¹²Technical University of Ostrava, Faculty of Economics, Department of Mathematical Methods in Economy, Ostrava, Czech Republic

Received March 16, 2014
Accepted November 10, 2015

The aim of this experimental study was to verify a new semi-spherical surgical tool for bipolar radiofrequency liver ablation, which can solve some of the disadvantages of the commonly used device, such as the long duration of ablation. A total of 12 pigs which were randomly divided into two groups were used. Each pig underwent resection of the two liver lobes. In group 1, pigs were treated with the commonly used device; in group 2 the newly developed semi-spherical device was used. During surgery and the post-surgical period, many categories were observed and later analyzed. The blood count and biochemistry were monitored on days 0, 14 and 30 from the operation. On day 14 since the liver resection, pigs underwent diagnostic laparoscopy to evaluate their condition focusing on the site of the liver lobe resection. On day 30 after operation, all pigs were euthanized and subjected to histopathological examination. Histopathological evaluation of thermal changes at the resection margin showed strong thermal alteration in both groups. Data between both groups were compared using median test for continuous variables and Fisher’s exact test for categorical variables. Statistical analyses were performed with IBM SPSS software version 18.0. Statistical analysis of collected data did not prove any significant (P < 0.05) differences between the commonly used device and the newly designed surgical tool.

Keywords

Animal study, pig model, liver ablation, radiofrequency energy.

Funding

This work was supported by MH CZ-DRO-FNOs/2012, MH CZ-DRO-FNOs/2013 and MH CZ-DROFNOs/ 2015, SGS VSB-TUO Grant No. SP2013/116 and by the project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund. This study was also supported by the Long-term Development Plan of the Faculty of Medicine, University of Ostrava. The work and the contributions were supported by the project SP2013/35 “Biomedical engineering systems IX” and TACR TA01010632 “SCADA system for control and measurement of process in real time”. The paper was elaborated in the framework of the IT4 Innovations Centre of Excellence Project, reg. no. CZ.1.05/1.1.00/02.0070 supported by the Operational Programme ‘Research and Development for Innovations’ funded by the Structural Funds of the European Union and the state budget of the Czech Republic.