Acta Vet. Brno 2016, 85: 9-16

Acute and subchronic toxicity studies of the original drug FS-1

Assem Kalykova1,2, Tatyana Kustova1, Zuriyadda Sakipova2, Naiyla Ibragimova1, Rinat Islamov1, David Vetchý3, Alexander Ilin1

1Scientific Centre for Anti-Infectious Drugs, Almaty, Republic of Kazakhstan
2S.D. Asfendiyarov Kazakh National Medical University, Pharmaceutical Technology Department, Almaty, Republic of Kazakhstan
3University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, Department of Pharmaceutics, Brno, Czech Republic

Received October 7, 2015
Accepted February 24, 2016

Interest in iodine complexes has increased significantly in recent years because of their wide spectrum of biological activity. The FS-1 is an ion nanostructured complex formed by proteins and/or polypeptides, carbohydrates, salts of alkali and alkaline earth metals with intercalated iodine. Patented in 2014, it is intended for the treatment of infectious diseases of bacterial origin including nosocomial infections and multidrug resistant tuberculosis. The aim of the study was to determine its acute and subchronic toxicity. The study of acute and subchronic toxicity was performed on adult Wistar rats according to OECD guidelines. The data on acute toxicity showed LD50 > 2,000 mg/kg after a single intragastric administration. Twenty-eight days of FS-1 administration at a dose of 500 mg/kg resulted in toxic effects. At a dose of 250 mg/kg, the toxic effects were temporary and a return to normal followed after the recovery period. Doses of 100 mg/kg had no adverse effects on the rats.


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