Acta Vet. Brno 2016, 85: 91-97

Changes of lidocaine concentration and physiological indices in dogs during anaesthesia with lidocaine and isoflurane combined with ketamine or fentanyl

Shi-Xia Zhang1,2, Xin Li2, Qing-Ming Ren2, Dong-Liang Niu2, Li Gao2, Hong-Bin Wang2

1Agricultural University of Hebei, College of Veterinary Medicine, Baoding, P. R. China
2Northeast Agricultural University, College of Veterinary Medicine, Harbin, P. R. China

Received November 4, 2014
Accepted November 10, 2015


1. Aguado D, Benito J, Gómez de Segura IA 2011: Reduction of the minimum alveolar concentration of isoflurane in dogs using a constant rate of infusion of lidocaine-ketamine in combination with either morphine or fentanyl. Vet J 189: 63-66 <>
2. Almeida TF, Fantoni DT, Mastrocinque S, Tatarunas AC, Imagawa VH 2007: Epidural anesthesia with bupivacaine, bupivacaine and fentanyl, or bupivacaine and sufentanil during intravenous administration of propofol for ovariohysterectomy in dogs. J Am Vet Med Assoc 230: 45-51 <>
3. Bhargava HN 1981: Antagonism of ketamine-induced anesthesia and hypothermia by thyrotropin releasing hormone and cyclo (His–Pro). Neuropharmacology 20: 699-702 <>
4. Correll GE, Maleki J, Gracely EJ, Muir JJ, Harbut RE 2004: Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome. Pain Med 5: 263-275 <>
5. Doherty T, Redua MA, Queiroz-Castro P, Egger C, Cox SK, Rohrbach BW 2007: Effect of intravenous lidocaine and ketamine on isoflurane minimum alveolar concentration in goats. Vet Anaesth Analg 34: 125-131 <>
6. Fozzard HA, Lee PJ, Lipkind GM 2005: Mechanism of local anesthetic drug action on voltage-gated sodium channels. Curr Pharm Des 11: 2671-2686 <>
7. Gaynor JS, Muir WW 2008: Handbook of Veterinary Pain Management. 2nd edn. Philadelphia, Pennsylvania: Mosby, 672 p.
8. Gold MS, Reichling DB, Hampl KF, Drasner K, Levine JD 1998: Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther 285: 413-421
9. Gusak V, Turkovic V, Nesek-Adam V, Lerotic I, Popovic M, Brajenovic N, Brcic Karaconji I, Vnuk D 2013: Lidocaine serum concentration after epidural administration in combination with morphine and fentanyl in rabbit - A preliminary study. Res Vet Sci 94: 651-655 <>
10. Ilkiw JE 1999: Balanced anesthetic techniques in dogs and cats. Clin Tech Small Anim Pract 14: 27-37 <>
11. Inagaki Y, Mashimo T, Kuzukawa A, Tsuda Y, Yoshiya I 1994: Epidural lidocaine delays arousal from isoflurane anesthesia. Anesth Analg 79: 368-372 <>
12. MacDougall LM, Hethey JA, Livingston A, Clark C, Shmon CL, Duke-Novakovski T 2009: Antinociceptive, cardiopulmonary, and sedative effects of five intravenous infusion rates of lidocaine in conscious dogs. Vet Anaesth Analg 36: 512-522 <>
13. Muir WW 3rd, Wiese AJ, March PA 2003: Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isoflurane. Am J Vet Res 64: 1155-1160 <>
14. Muir WW, Sams R 1992: Effects of ketamine infusion on halothane minimal alveolar concentration in horses. Am J Vet Res 53: 1802-1806
15. Muir WW, Skarda RT, Milne DW 1977: Evaluation of xylazine and ketamine hydrochloride for anesthesia in horses. Am J Vet Res 38: 195-201
16. Pascoe PJ 2000: Opioid analgesics. Vet Clin North Am Small Anim Pract 30: 757-752 <>
17. Song JJ, Han YJ, Lee JR, Song HS 1994: Dosage and plasma concentration of local anesthetics in epidural anesthesia for Caesarean section. Korean J Anesthesiol 27: 782-791 <>
18. Ulugol A, Dost T, Dokmeci D, Akpolat M, Karadag CH, Dokmeci I 2000: Involvement of NMDA receptors and nitric oxide in the thermoregulatory effect of morphine in mice. J Neural Transm 107: 515-521 <>
19. Wallace MS, Laitin S, Licht D, Yaksh TL 1997: Concentration effect relation for intravenous lidocaine infusions in human volunteers: effects on acute sensory threshold and capsaicin-evoked hyperpathia. Anesthesiology 86: 1262-1272 <>
20. Wilson J, Doherty TJ, Egger CM, Fidler A, Cox S, Rohrbach B 2008: Effects of intravenous lidocaine, ketamine, and the combination on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg 35: 289-296 <>
21. Zilberstein LF, Moens YP, Leterrier E 2008: The effect of local anaesthesia on anaesthetic requirements for feline ovariectomy. Vet J 178: 214-218 <>
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