Acta Vet. Brno 2016, 85: 127-132

The influence of sodium propionate on blood glucose, insulin and cortisol concentrations in calves of different ages

Biljana Radojičić1, Mirjana Joksimović-Todorović2, Maja Bukvić1, Predrag Simeunović1, Murat Kakishev3, Nermin Pračić4

1University of Belgrade, Faculty of Veterinary Medicine, Department of Ruminants and Swine Disease, Belgrade, Serbia
2University of Belgrade, Faculty of Agriculture, Department of Nutrition, Belgrade-Zemun, Serbia
3West Kazakhstan Agrarian Technical University named after Zhangir Khan, Uralsk, Kazakhstan
4University of Bihać, Biotechnical Faculty, Bihać, Bosnia and Herzegovina

Received October 26, 2015
Accepted May 2, 2016

The process of gluconeogenesis in ruminants is under the direct influence of insulin and glucocorticoid hormones. The goal of this study was to determine the effects of added Na-propionate on the neuroendocrine regulation of blood glucose in calves at three specific physiological periods: on exclusive milk nutrition; on mixed milk and forage nutrition; and with established ruminant digestion. The influence of Na-propionate on blood glucose, insulin and cortisol concentrations was examined in the same 20 female Holstein calves at different stages of forestomach development (15 days, 2 months, and 4 months of age of calves). Group 1 of calves (n = 10) received Na-propionate intravenously; group 2 (n = 10) received Na-propionate mixed in milk. Blood sampling was performed 1 and 3 h after Na-propionate administration. After i.v. administration of Na-propionate, a significant increase (P < 0.05) in blood glucose concentration was observed 1 h after administration only in calves aged 2 and 4 months; blood insulin concentration was significantly higher (P < 0.01) 1 and 3 h after i.v. administration in 2-month-old calves; and cortisol concentration increased (P < 0.01) 1 h after administration in each selected calf in all testing periods. Orally administered Na-propionate led to a significant increase (P < 0.01) of insulin concentration 1 and 3 h after administration in 15-day-old calves, and 3 h after administration in 2-month-old calves. Based on these results it could be assumed that i.v. and p.o. administration of Na-propionate affects the neuroendocrine regulation of glycaemia in calves of different age.


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