Acta Vet. Brno 2016, 85: 239-245

Comparison of continuous versus intermittent furosemide administration in dogs with acute heart failure

Zita Filipejová, Carlos Fernando Agudelo Ramírez, Michal Crha

University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Brno, Czech Republic

Received April 11, 2016
Accepted June 23, 2016


1. Adin DB, Taylor AW, Hill RC, Scott KC, Martin FG 2003: Intermittent bolus injection versus continuous infusion of furosemide in normal adult greyhound dogs. J Vet Intern Med 17: 632-636 <>
2. Allen LA, Turer AT, Dewald T, Stough WG, Cotter G, O’Connor CM 2010: Continuous versus bolus dosing of furosemide for patients hospitalized for heart failure. Am J Cardiol 105: 1794-1797 <>
3. Atkins C, Bonagura J, Ettinger S, Fox P, Gordon S, Haggstrom J, Hamlin R, Keene B, Luis-Fuentes V, Stepien R 2009: Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet Intern Med 23: 1142-1150 <>
4. Aziz EF, Alviar CL, Herzog E, Cordova JP, Bastawrose JH, Pamidimukala CK, Tojino A, Park TS, Musat D, Kukin M 2011: Continuous infusion of furosemide combined with low-dose dopamine compared to intermittent boluses in acutely decompensated heart failure is less nephrotoxic and carries a lower readmission at thirty days. Hellenic J Cardiol 52: 227-235
5. Bachmann M, Waldrop JE 2012: Noncardiogenic pulmonary edema. Compend Contin Educ Vet 34: E1
6. Copeland JG, Campbell DW, Plachetka JR, Salomon NW, Larson DF 1983: Diuresis with continuous infusion of furosemide after cardiac surgery. Am J Surg 146: 796-799 <>
7. Dormans TP, Van Meyel JJ, Gerlag PG, Tan Y, Russel FG, Smits P 1996: Diuretic efficacy of high dose furosemide in severe heart failure: Bolus injection versus continuous infusion. J Am Coll Cardiol 28: 376-382 <>
8. Felker GM, Lee KL, Bull DA, Redfield MM, Stevenson LW, Goldsmith SR, Lewinter MM, Deswal A, Rouleau JL, Ofili EO, Anstrom KJ, Hernandez AF, Mcnulty SE, Velazquez EJ, Kfoury AG, Chen HH, Givertz MM, Semigran MJ, Bart BA, Mascette AM, Braunwald E, O’connor CM 2011: Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med 364: 797-805 <>
9. Gava FN, Zacche E, Ortiz EM, Champion T, Bandarra MB, Vasconcelos RO, Barbosa JC, Camacho AA 2013: Doxorubicin induced dilated cardiomyopathy in a rabbit model: An update. Res Vet Sci 94: 115-121 <>
10. Glaus TM, Schellenberg S, Lang J 2010: Cardiogenic and non cardiogenic pulmonary edema: Pathomechanisms and causes. Schweiz Arch Tierheilkd 152: 311-317 <>
11. Harada K, Ukai Y, Kanakubo K, Yamano S, Lee J, Kurosawa TA, Uechi M 2015: Comparison of the diuretic effect of furosemide by different methods of administration in healthy dogs. J Vet Emerg Crit Care (San Antonio) 25: 364-371 <>
12. Hinchcliff KW, Mckeever KH, Muir WW, 3rd 1991: Furosemide-induced changes in plasma and blood volume of horses. J Vet Pharmacol Ther 14: 411-417 <>
13. Hori Y, Ohshima N, Kanai K, Hoshi F, Itoh N, Higuchi S 2010: Differences in the duration of diuretic effects and impact on the renin-angiotensin-aldosterone system of furosemide in healthy dogs. J Vet Med Sci 72: 13-18 <>
14. Chatterjee K, Zhang J, Honbo N, Karliner JS 2010: Doxorubicin cardiomyopathy. Cardiology 115: 155-162 <>
15. Johansson AM, Gardner SY, Levine JF, Papich MG, Lafevers DH, Fuquay LR, Reagan VH, Atkins CE 2003: Furosemide continuous rate infusion in the horse: Evaluation of enhanced efficacy and reduced side effects. J Vet Intern Med 17: 887-895 <>
16. Kittleson MD 1998: Pathophysiology of heart failure. In: Kittleson MD (Ed.): Small Animal Cardiovascular Medicine. Mosby, St. Louis, pp 136-148
17. Lahav M, Regev A, Ra’anani P, Theodor E 1992: Intermittent administration of furosemide vs continuous infusion preceded by a loading dose for congestive heart failure. Chest 102: 725-731 <>
18. Lefebvre HP 2011: Renal function testing. In: Joe Bartges DJP (Ed.): Nephrology and urology of small animals. Blackwell Publishing, Ames, pp. 91-96
19. Luciani GB, Nichani S, Chang AC, Wells WJ, Newth CJ, Starnes VA 1997: Continuous versus intermittent furosemide infusion in critically ill infants after open heart operations. Ann Thorac Surg 64: 1133-1139 <>
20. Michael Felker G 2010: Diuretic management in heart failure. Congest Heart Fail 16 Suppl 1: S68-72 <>
21. Murray JF 2011: Pulmonary edema: Pathophysiology and diagnosis. Int J Tuberc Lung Dis 15: 155-160
22. Oh SW, Han SY 2015: Loop diuretics in clinical practice. Electrolyte Blood Press 13: 17-21 <>
23. Ostermann M, Alvarez G, Sharpe MD, Martin CM 2007: Frusemide administration in critically ill patients by continuous compared to bolus therapy. Nephron Clin Pract 107: 70-76 <>
24. Sanjay S, Annigeri RA, Seshadri R, Rao BS, Prakash KC, Mani MK 2008: The comparison of the diuretic and natriuretic efficacy of continuous and bolus intravenous furosemide in patients with chronic kidney disease. Nephrology (Carlton) 13: 247-250 <>
25. Vilar P, Couto CG, Westendorf N, Iazbik C, Charske J, Marin L 2008: Thromboelastographic tracings in retired racing greyhounds and in non-greyhound dogs. J Vet Intern Med 22: 374-379 <>
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