Acta Vet. Brno 2017, 86: 249-261

Parenteral iron administration in suckling piglets – a review

Martin Svoboda1, Jonáš Vaňhara1, Jana Berlinská2

1University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Ruminant and Swine Clinic, Brno, Czech Republic
2University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Animal Protection, Welfare and Behaviour, Brno, Czech Republic

Received April 6, 2017
Accepted October 2, 2017


1. Adeleye OO, Brett M, Blomfield D, Guy JH, Edwards SA 2014: The effect of algal biomass supplementation in maternal diets on piglet survival in two housing systems. Livest Sci 162: 193-200 <>
2. Amezcua R, Frienship R, Dewey CE 2008. An investigation of presence of Escherchia coli O149:K91:F4 on pig farms in southern Ontario and the use of antimicrobials and risk factors associated with the presence of this serogroup. Can Vet J 49: 39-45
3. Beaumont C 2010. Multiple regulatory mechanism act in concert to control ferroportin expression and heme iron recycling by macrophages. Haematologica 95: 1233-1236 <>
4. Bhattarai S, Nielsen JP 2015. Early indicators of iron deficiency in large piglets at weaning. J Swine Health Prod 23: 10-17
5. Braude R, Chamberlain AG, Kotarbinska M, Mitchell KG 1962. The metabolism of iron in piglets given labelled iron either orally or by injection. Br J Nutr 16: 427-449 <>
6. Brugnara C, Zemanovi D, Sorette M, Ballas SK, Platt O 1997. Reticulocyte haemoglobin. An integrated parameter for evaluation of erythropoetic activity. Am J Clin Pathol 108: 133-142 <>
7. Bruininx E, Swinkels J, Permentioer C, Jetten C, Gentry J, Schrama J 2000. Effect of an additional iron injection on growth and humoral immunity of weaning pigs. J Swine Health Prod 23: 10-17
8. Bullen JJ, Rogers HJ, Griffiths E 1978: Role of iron in bacterial infection. Curr Top Microbiol Immunol 80: 1-35
9. Carlsson H, Lindvall S, Thafvelin B 1974: Properties of a complex of iron and a sorbitol-gluconic acid polymer for treatment of piglet anaemia. Acta Vet Scand 15: 100-110
10. Cullen P, Söffker J, Höpfl M, Bremer C, Schlaghecker R, Mehrens T 1999. Hypochromic red cells and reticulocyte haemoglobin content as markers of iron deficient erythropoesis in patients undergoing chronic haemodialysis. Nephrol Dial Transplant 14: 659-665 <>
11. d’Onofrio G, Chirillo R, Yini G, Caenaro G, Tommasi M, Micciuli G 1995: Simultaneous measurement of reticulocyte and red blood cell indexes in healthy subjects and patients with microtic and macrotic anemia. Blood 85: 818-823
12. Daykin MM, Griffiths AJ, Towlerton RG 1982: Evaluation of the parenteral iron requirement of early weaned pigs. Vet Rec 110: 535
13. Dziaman T, Jurgowiak M, Olinski R 2011: Association between body iron stores and level of oxidatively modified DNA bases. Biotechnologia 2: 159-165 <>
14. Egeli AK 1998a: Iron deficiency anemia in piglets. The Norwegian College of Veterinary Medicine. Department of Reproduction and Forensic Medicine. In Jorgensen A, Brun E (2000): Haemoglobin Status in 3 Weeks Piglets in Herds with Different Strategies for Iron Supply. IPVS Congress, Melbourne, 62 p.
15. Egeli AK, Framstad T 1998. Evaluation of the efficacy of perorally administered glutamic acid-chelated iron and iron-dextran injected subcutaneously in Duroc and Norwegian Landrace piglets. J Vet Med A Physiol Pathol Clin Med 45: 53-61 <>
16. Egeli AK, Framstad T, Morberg H 1998b. Clinical biochemistry, haematology and body weight in piglets. Acta Vet Scand 39: 381-393
17. Ekman KM, Iwanska S 1966. Studies on iron metabolism in normal and anemic nursing pigs. J Vet Med B Infect Dis Vet Public Health 13: 585-595
18. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD 1992. Serum transferrin receptor distinguishes the anaemia of chronic disease from deficiency anaemia. J Lab Clin Med 19: 385-390
19. Furugouri K 1975: Characteristic aspects of iron metabolism in piglets. Jap Agric Res Q 9: 171
20. Gentry J, Swinkels J, Lindenmann M, Shrama J 1997. Effect of hemoglobin and immunization status on energy metabolism of weaning pigs. J Anim Sci 75: 1032-1040 <>
21. Groebel K, Hoelzle K, Wittenbrink MM, Ziegler U, Hoelzle LE 2009: Mycoplasma suis invades porcine erythrocytes. Infect Immun 77: 576-584 <>
22. Hansen SL, Trakooljul N, Spears JW, Liu HC 2010: Age and dietary iron affect expression of genes involved in iron acquisition and homeostasis in young pig. J Nutr 140: 215-236 <>
23. Hastka J, Lassere JJ, Scwarzbeck A, Hehlmann R 1994: Central role of zinc protoporphyrin in staging iron deficiency. Clin Chem 40: 768-773
24. Haugegaard J, Wachmann H, Kristensen PJ 2008: Effect of supplementing fast growing late-weaned piglets twice with 200 mg iron dextran intra-muscular. The Pig Journal 61: 69-73
25. Heinritzi K, Plonait H 1997: Blutkrankheiten. In Plonait H, Bickhardt K (Eds): Lehrbuch der Scheinekrankheiten (2nd edn), Parey Buchverlag Berlin, 190 p.
26. Hirayama KJ, Yasutake K 1998: Free radicals and trace elements. J Trace Elem Exper Med 11: 209-217 <<209::AID-JTRA11>3.0.CO;2-V>
27. Holmgren N 1996: Polyarthritis in piglets caused by iron dextran. Proc 14th IPVS Congress, Bologna, Italy 1996, p. 603
28. Holter PH, Framstad T, Aulif A, Refsum HE, Sjaastad ØV 1991: Effect of iron treatment erythrocyte parameters in postnatal anemia of the pig. Pediatr Hematol Oncol 8: 1-11 <>
29. Chen J, Han JH, Guan WT, Chen F, Wang CX, Zhang YZ, Lv YT, Lin G, 2016. Selenium and vitamin E in sow diets: II. Effect on selenium status and antioxidant status of the progeny. Anim Feed Sci Technol 221: 101-110 <>
30. Ioannou GN, Spector J, Scott K, Rockey DC 2002. Prospective evaluation of a clinical guideline for the diagnosis and management of iron deficiency anemia. Am J Med 113: 281-287 <>
31. Jain NC 1986: Shalm’s Veterinary Haematology (4th edn), pp 240-255
32. Jolliff JS, Mahan DC 2011: Effect of injected and dietary iron in young pigs on blood hematology and postnatal pig growth performance. J Anim Sci 89: 4068-4080 <>
33. Kamphues J, Männer K, Netzler C 1992: Effect of a 2nd iron injection in suckling pigs on iron retention and performance before and after weaning, in: Proceedings of the 12th IPVS Congress, August 1992, The Hauge, The Netherlands, 601 p.
34. Kaneko JJ 1980: Clinical Biochemistry of Domestic Animals (3rd edn), Academic Press, New York, pp. 649-669
35. Kaneko JJ 1993: Clinical Biochemistry of Domestic Animals (4th edn), Academic Press, New York
36. Katkiewicz M, Malicka E, Preibisch J 1986: Effect of iron overload on the morphology of some organs in piglets. Pol Arch Vet 25: 75
37. Kievit GP 2012. Needle-free injection devices versus regular injection techniques for iron supplementation to piglets. Utrecht University Repository (online, accessed 2017-03-11)
38. Kolb E, Hoffman U 1989. Zur Frage der zweckmässigen Form der Anwendung von Fe-dextran, seiner Verwertung sowie des Mechanismus einer möglichen Schädigung der Ferkel. Mh Vet Med 44: 497-501
39. Kolb E, Hoffmann U, Nestler K 1992: Untersuchungen über den Gehalt an Eisen, Kupfer und Zink in verschiedenen Geweben (Magen-Darm-Kanal, Lymphknoten, Muskulatur, Herz, Leber, Milz, Niere, Pankreas, Knochenmark) bei neugeborenen Ferkeln nach orale und intramuskulare Verabreichung von Fe-Dextran. Mh Vet Med 47: 271-278
40. Kubik A, O’Sullivan TL, Harding JCS, Friendship RM 2015: An Investigation of Iron Deficiency and Anemia in Piglets. Centralia Swine Research Update January 28th, Kirkton, Ontario 2015
41. Langie SAS, Kowalczyk P, Tudek B, Zabielski R, Dziaman T, Olinski R, van Schooten FJ, Godschalk RWL 2010: The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets. Mutat Res-Genet Tox 695: 75-80 <>
42. Larkin H, Hannan J 1984: Intestinal absorption and structure in iron deficient piglets. Res Vet Sci 36: 199-204 <>
43. Lehmann P 2001: Anaemia: A major medical problem in the world. Eur Clin Lab 20: 26-30
44. Lipinski P, Starzynski RR, Canonne-Hergaux B, Tudek R, Olinski P, Kowalczyk P, Dziamam T, Thibaudeau O, Gralak MA, Smuda E, Wolinski J, Usinska A, Zabielskiá R 2010. Benefits and risks of iron supplementation in anemic neonatal pigs. Am J Pathol 177: 1233-1243 <>
45. Loudenslager MJ, Ku PK , Whetter PA , Ullrey DE, Whitehair CK , Stowe HD , Miller ER 1986: Importance of Diet of dam and colostrum to the biological antioxidant status and parenteral iron tolerance of the pig. J Anim Sci 63: 1905-1914 <>
46. Loudenslager MJ, Ku PK, Whetter PA, Ullrey DE, Whitehair CK, Stowe HD, Mahan DC, Vallet JL 1997: Vitamin and mineral transfer during fetal development and the early postnatal period in pigs. J Anim Sci 75: 2731-2738
47. Mahan DC, Newton EA 1995. Effect of initial breeding weight on macromineral and micromineral composition over a 3-parity period using a high-producing sow genotype. J Anim Sci 73: 151-158 <>
48. McDougall IC, Cavill I, Hulme B, Brain B, McGregor E, McKay P 1992: Detection of functional iron deficiency during erythropoetin treatment: a new approach. Br Med J 304: 225-226 <>
49. McDowell LR 1992: Iron. In: Minerals in Animal and Human Nutrition. Academic Press Inc. New York, pp. 152-175
50. Miller ER, Ullrey DE 2007: Baby Pig Anemia, Michigan State University (online, accessed 2017-03-11)
51. Moritz A, Schwendenwein I, Kraft W 2014. Hämatologie. In Klinische Labordiagnostik in der Tiermedizin (Moritz A, Hrsg.), Verlag Schattauer 7: 79-159
52. Murphy KA, Friendship RM, Dewey CE 1997. Effect of weaning age and dosage of supplemented iron on the hemoglobin concentrations and growth rate piglets. J Swine Health Prod 5: 135-138
53. Murray R, Granner DK, Mayes PA, Rodwell VW 2000: Harper’s Biochemistry, (25th edn). Appleton & Lange, Stamford, 927 p.
54. Nathanson MH, McLaren GD 1984: Internal iron exchange in normal and iron-deficient Beagle dogs: relationship to iron absorption (abstr). Clin Res 32: 317a
55. National Research Council 1979: Nutrient Requirements of Domestic Animals. Nutrient Requirements of Swine, Eighth Revised Ed. National Academy of Science-National Research Council, Washington, D.C.
56. National Research Council 2012: Nutrient Requirements of Swine. Eleventh Revised Edition. National Academic Press, Washington, D.C.
57. Payne HG, Mullan BP, Nicholls RR, McCulloch SM, Pluske JR, Clarke P 2005: Haematological indices of piglets provided with parenteral iron dextran and creep feed or soil prior to weaning. Manipulating Pig Production X. Proceedings of the Tenth Biennial Conference of the Australasian Pig Science Association (APSA), 27-30 November, Christchurch, New Zealand, 157 p.
58. Perri AM, Friedship RM, Harding JCS, O’Sullivan TL 2015: An investigation of iron deficiency and anemia in piglets and the effect of iron status at weaning on post-weaning performance. J Swine Health Prod 24: 10-20
59. Perri AM, Friedship RM, Harding JCS, O’Sullivan TL 2016: An investigation of iron deficiency and anemia in piglets and the effect of iron status at weaning on post-weaning performance. J Swine Health Prod 24: 10-20
60. Peters JC, Mahan DC 2008: Effects of neonatal iron status, iron injections at birth, and weaning in young pigs from sows fed either organic or inorganic trace minerals. J Anim Sci 86: 2261-2269 <>
61. Porter DR, Sturrock RD, Capell HA 1994: The use of serum ferritin estimation in investigation of anaemia in patients with rheumatoid arthritis. Clin Exp Rheumatol 12: 179-182
62. Radostits OM, Blood DC, Gay CC 1994: Iron deficiency. In Radostits OM et al.: Veterinary Medicine Bailliere Tindall, London, pp 1398-1401
63. Rantzer D, Andersson M, Botermans J, Olsson ACH, Svendsen J 2010: Route of iron supplementation to piglets: effects on hemoglobin, piglet growth and infectious disease. Proceedings of the 21st IPVS Congress, Vancouver, Canada – July 18-21 2010.
64. Rincker M, Hill G, Link J, Rowntree J 2004: Effects of dietary iron supplementation on growth performance, hematological status, and whole-body mineral concentration of nursery pigs. J Anim Sci 82: 3189-3197 <>
65. Segales J, Domingo M, Chianini F, Majo N 2004: Immunosuppression in postweaning multisystemic wasting syndrome affected pigs. Vet Microbiol 98: 151-158 <>
66. Sladic-Simic D, Cvetkovic M 1978: Iron resorption and iron store in piglets after i.m. injection of 59Fe-iron dextran. Zbl Vet Med A 25: 680 <>
67. Smith JE 1997: Iron metabolism and its disorders. In Kaneko JJ, Harvey JW, Bruss ML (eds): Clinical Biochemistry of Domestic Animals. Academic Press, pp 223-239
68. Smith JE, Cipriano JE 1987: Inflammation-induced changes in serum iron analytes and ceruloplasmin of Shetland ponies. Vet Pathol 24: 354-356 <>
69. Starzynski RR, Laarakkers CM, Tjalsma H, Swinkels DW, Pieszka M, Stys A, Mickiewicz M, Lipinski P 2013. Iron supplementation in suckling piglets: How to correct iron deficiency anemia without affecting plasma hepcidin levels. PloS One 49: e64022 <>
70. Steinhardt M, Bünger U, Furcht G 1984: Zum Eisenbedarf des Schweines in den ersten 2 Lebensmonaten. Arch Exper Vet Med 38: 497-515
71. Steinhardt M, Bünger U, Furcht G, Shoenfelder E 1982a: Untersuchungen zur Festlegung von Normalwerten für das rote Blutbild des Ferkels. Arch Exper Vet Med 36: 707-719
72. Steinhardt M, Bünger U, Furcht G, Shoenfelder E 1982b: Beziehungen zwischen Blutbildung und Eisenstoffwechsel beim Ferkel. Arch Exper Vet Med 36: 729-737
73. Steinhardt M., Bünger U, Furcht G 1984: Zum Eisenbedarf des Schweines in den ersten 2 Lebensmonaten. Archives of experimental veterinary medicine 38: 497-515
74. Suominen P, Punnonen K, Rajarnäki A, Irjala K 1998: Serum transferrin receptor and transferrin receptorferritin index identify healthy subjects with subclinical iron deficits. Blood 92: 2934-2939
75. Süveges T, Glávits R 1976: Piglet losses due to parenteral application of iron-dextran preparations. Acta Vet Acad Sci Hung 26: 257-262
76. Svoboda M, Drabek J 2005a: Iron deficiency in suckling piglets: etiology, clinical aspects and diagnosis (A review). Folia Vet 49: 104-111
77. Svoboda M, Drabek J 2005b: Iron deficiency in suckling piglets: parenteral and oral iron administration to piglets (A review). Folia Vet 49: 165-174
78. Svoboda M, Drabek J 2007: Intramuscular versus subcutaneous administration of iron dextran in suckling piglets. Acta Vet Brno 76: 11-15 <>
79. Svoboda M, Fricek R, Drabek J 2008: Reticulocyte indices in diagnosis of iron deficiency in suckling piglets. Bull Vets Inst Pulawy 52: 125-130
80. Taylor DJ 1989: Piglet anaemia. In Pig Diseases, Fifth Edition, Diamond Farm Book Pubns, pp 212-215
81. Thomas Ch, Thomas L 2002: Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin Chem 48: 1066-1076
82. Tollerz G 1973: Vitamin E, selenium (and some related compounds) and tolerance iron in piglets Acta Agric Scand Suppl 19: 184
83. Tybirk P, Sloth NM, Jørgensen L 2013: Nutrient Requirement Standards. Pig Research Centre. (Online, accessed 2017-03-14) http://www.Pigresearchcentre.Dk/~/Media/Pdf/Eng/Normer_Naeringstoffer%20uk/Nutrient_Standards_April2013.Ashx
84. Underwood EJ, Suttle NF 1999: Iron In mineral Nutrition of Lifestock. CAB International, pp 375-396
85. Van Kempen GJM 1987: Avoid iron deficiency in piglets. Pigs 3: 10-11
86. Velásquez JI, Aranzazu D 2004: An acute case of iron toxicity on newborn piglets from vitamin E/Se deficient sows. Revista Colombiana de Ciencias Pecuarias 17: 60-62
87. Venn JAJ, McCance RA, Widdowson EM 1947: Iron metabolism in piglet anaemia. J Comp Pathol Ther 57: 314-325 <>
88. Vermeer JE, Kuijpers AH, Elbers AR 2002: Comparison of the efficacy of two different iron supplements for anemia prevention in piglets. Tijdschr Diergeneeskd 127: 110-104
89. Von Bollwahn W, Knörl H, Heinritzi K 1983: Klinik und Diagnose des latenten Eisenmangels beim Ferkel. Prakt Tierartz 64: 294-299
90. Vrigazov A, Dilov P 1976: Resorption and distribution of iron-dextran praparations in pigs, calves, and lambs. Proceedings of the 20th World Veterinary Congress, Thessaloniki 1: 436-440
91. Wattanakul W, Bulman CA, Edge HL, Edwards SA 2005: The effect of creep feed, presentation method on feeding behaviour, intake and performance of suckling piglets. Appl Anim Behav Sci 92: 27-36 <>
92. Wei KQ, Xu ZR, Luo XG, Zeng LL, Chen WR, Timothy MF 2005, Effects of iron from an amino acid complex on the iron status of neonatal and suckling piglets. Am J Anim Sci 18: 1485-1491
93. Wilhelm R 1998: Iron toxicity in newborn pigs. In Aiello SE (Ed): The Merck Veterinary Manual, Merck & co., inc., 2071 p.
94. Yu IT, Lin J, Wu JF, Yen, HT, Lee SL, Yang TS 2002: Reevaluation of the necessity of iron injection to newborn piglets. Asian-Austr Anim Sci 15: 79-83 <>
95. Zimmermann W 1995: Auswirkungen diverser Anämieprohylaxeformen auf die Blutparameter der Saugferkel. Dtch Tierärtz Wschr 102: 32-38
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