Acta Vet. Brno 2019, 88: 187-192

https://doi.org/10.2754/avb201988020187

Effects of intramuscular alfaxalone-midazolam combination in pigs

Cecilia Vullo1, Marina Meligrana2, Adolfo Maria Tambella2, Angela Palumbo Piccionello2, Fabrizio Dini2, Giuseppe Catone2

1University of Camerino, School of Pharmacy, Camerino (MC), Italy
2University of Camerino, School of Biosciences and Veterinary Medicine, Matelica (MC), Italy

Received January 11, 2019
Accepted April 23, 2019

References

1. Ajadi RA, Smith OF, Makinde AFM, Adeleye OE 2008: Increasing ketamine dose enhances the anaesthetic properties of ketamine-xylazine-midazolam combination in growing pigs. J S Afr Vet Assoc 79: 205-207 <https://doi.org/10.4102/jsava.v79i4.273>
2. Bettschart-Wolfensberger R, Stauffer S, Hässig M, Flaherty D, Ringer SK 2013: Racemic ketamine in comparison to S-ketamine in combination with azaperone and butorphanol for castration of pigs. Schweiz Arch Tierheilkd 155: 669-675 <https://doi.org/10.1024/0036-7281/a000532>
3. Bigby SE, Carter JE, Bauquier S, Carter JE 2017: The use of alfaxalone for premedication, induction and maintenance of anaesthesia in pigs: a pilot study. Vet Anaesth Analg 44: 905-909 <https://doi.org/10.1016/j.vaa.2016.06.008>
4. Bustamante R and Valverde A 1997: Determination of sedative dose and influence of droperidol and midazolam on cardiovascular function in pigs. Can J Vet Res 61: 246-250
5. Calzetta L, Rossi P, Bove P, Alfonsi P, Bonizzi L, Roncada P, Bernardini R, Ricciardi E, Montuori M, Pistocchini E, Mauti P, Mattei M 2014: A novel and effective balanced intravenous-inhalant anaesthetic protocol in swine by using unrestricted drugs. Exp Anim 63: 423-433 <https://doi.org/10.1538/expanim.14-0011>
6. De Monte V, Staffieri F, Di Meo A, Vannucci J, Bufalari A 2015: Comparison of ketamine–dexmedetomidine–methadone and tiletamine–zolazepam–methadone combinations for short-term anaesthesia in domestic pigs. Vet J 205: 364-368 <https://doi.org/10.1016/j.tvjl.2015.05.011>
7. Gupta S, Westfall T, Lechner A, Knuepfer MM 2005: Teaching principles of cardiovascular function in a medical student laboratory. Adv Physiol Ed 29: 118-127 <https://doi.org/10.1152/advan.00052.2004>
8. Hall LW, Clarke KW, Trim CM 2001: Anaesthesia of the pig. In Hall LW, Clarke KW, Trim CM (Eds): Veterinary Anesthesia. 10th edn. WB Sauders, London, pp. 367-383
9. Heinonen ML, Raekallio MR, Oliviero C Ahokas S, Peltoniemi OA 2009: Comparison of azaperone–detomidine–butorphanol–ketamine and azaperone–tiletamine–zolazepam for anaesthesia in piglets. Vet Anaesth Analg 36: 151-157 <https://doi.org/10.1111/j.1467-2995.2008.00443.x>
10. Henrikson H, Jensen-Waern M, Nyman G 1995: Anaesthetics for general anaesthesia in growing pigs. Acta Vet Scand 36: 401-411
11. Huter L, Schwarzkopf K, Preussler NP, Gaser E, Schubert H, Karzai W, Schreiber T 2004: Measuring cardiac output in one-lung ventilation: a comparison of pulmonary artery and trans-pulmonary aortic measurements in pigs. J Cardiothor Vasc Anaesth 18: 190-193 <https://doi.org/10.1053/j.jvca.2004.01.026>
12. Keates H, 2003: Induction of anesthesia in pigs using a new alphaxalone formulation. Vet Rec 153: 627-628 <https://doi.org/10.1136/vr.153.20.627>
13. Keates HL, van Eps AW, Pearson MR, 2012: Alfaxalone compared with ketamine for induction of anaesthesia in horses following xilazine and guaifenesin. Vet Anaesth Analg 39: 591-598 <https://doi.org/10.1111/j.1467-2995.2012.00756.x>
14. Kim MJ, Park CS, Jun MH, Kim MC 2007: Antagonistic effects of yohimbine in pigs anaesthetised with tiletamine/zolazepam and xylazine. Vet Rec 161: 620-624 <https://doi.org/10.1136/vr.161.18.620>
15. Lan NC, Gee KW 1994: Neuroactive steroid actions at the GABAA receptor. Horm Behav 28: 537-544 <https://doi.org/10.1006/hbeh.1994.1052>
16. Lee JY, Kim MC 2012: Anesthesia of growing pigs with tiletamine-zolazepam and reversal with flumazenil. J Vet Med Sci 74: 335-339 <https://doi.org/10.1292/jvms.10-0501>
17. Malavasi LM 2015: Swine. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (Eds): Lumb and Jones’ Veterinary Anesthesia and Analgesia. 5th edn. John Wiley & Sons, Inc, Oxford, pp. 928-940
18. Meyer RE, Fish RE 2008: Pharmacology of injectable anesthetics, sedatives, and tranquilizers. In: Fish RE, Danneman P, Brown M, Karas A (Eds): Anesthesia and Analgesia in Laboratory Animals. 2nd edn, Elsevier Inc, London, pp. 44-47
19. Michou JN, Leece EA, Brearley JC 2012: Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dog. Vet Anaesth Analg 39: 275-281 <https://doi.org/10.1111/j.1467-2995.2012.00709.x>
20. Nishimura R, Sakaguchi M, Mochizuki M, Sasaki N, Takahashi H, Tamura H, Takeuchi A 1992: A balanced anaesthesia with a combination of xylazine, ketamine and butorphanol and its antagonism by yohimbine in pigs. J Vet Med Sci 54: 615-620 <https://doi.org/10.1292/jvms.54.615>
21. Quandt J 2013: Analagesia, anesthesia, and chemical restraint in the emergent small animal patient. Vet Clin North Am Small Anim Pract 43: 941-953 <https://doi.org/10.1016/j.cvsm.2013.03.008>
22. Rankin DC 2015: Sedatives and Tranquilizers. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA (Eds): Lumb and Jones’ Veterinary Anesthesia and Analgesia. 5th edn. John Wiley & Sons, Inc, Oxford, pp: 196-206
23. Sakaguchi M, Nishimura R, Sasaki N, Ishiguro T, Tamura H, Takeuchi A 1995: Chemical restraint by medetomidine-ketamine and its cardiopulmonary effects in pigs. Zentralbl Veterinärmed. Reihe A 42: 293-299
24. Santos M, Bertrán de Lis BT, Tendillo FJ 2016: Effects of intramuscular dexmedetomidine in combination with ketamine or alfaxalone in swine. Vet Anaesth Analg 43: 81-85 <https://doi.org/10.1111/vaa.12259>
25. Santos González M, Bertrán de Lis BT, Tendillo Cortijo FJ 2013: Effects of intramuscular alfaxalone alone or in combination with diazepam in swine. Vet Anaesth Analg 40: 399-402 <https://doi.org/10.1111/vaa.12033>
26. Smith AC, Zellner JL, Spinale FG, Swindle MM 1991: Sedative and cardiovascular effects of midazolam in swine. Lab Anim Sci 41: 157-161
27. Sweitzer RA, Ghneim GS, Gardner IA, van Vuren D, Gonzales BJ, Boyce WM 1997: Immobilization and physiological parameters associated with chemical restraint of wild pigs with Telazol® and xylazine hydrochloride. J Wildl Dis 33: 198-205 <https://doi.org/10.7589/0090-3558-33.2.198>
28. Tamura J, Ishizuka T, Fukui S, Oyama N, Kawase K, Miyoshi K, Sano T, Pasloske K, Yamashita K 2015: The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs. J Vet Med Sci 77: 289-296 <https://doi.org/10.1292/jvms.14-0368>
29. Warne LN, Beths T, Whittem T, Carter JE, Bauquier SH 2015: A review of the pharmacology and clinical application of alfaxalone in cats. Vet J 203: 141-148 <https://doi.org/10.1016/j.tvjl.2014.12.011>
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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