Acta Vet. Brno 2019, 88: 225-232

The effect of triamcinolone in liposomes on oral wound healing in rats

Vladimira Erjavec1, Zlatko Pavlica1, Tomáš Fichtel2, Milan Petelin3

1University of Ljubljana, Veterinary Faculty, Small animal clinic, Ljubljana, Slovenia
2University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Brno, Czech Republic
3University of Ljubljana, Faculty of Medicine, Department of Oral Medicine and Periodontology, Ljubljana, Slovenia

Received July 23, 2018
Accepted April 23, 2019


1. Bremecker KD, Strempel H, Klein G 1984: Novel concept for a mucosal adhesive ointment. J Pharm Sci 73: 548-552 <>
2. Brennan PA, Thomas GJ, Langdon JD 2003: The role of nitric oxide in oral diseases. Arch Oral Biol 48: 93-100 <>
3. Duchene DE, Touchard F, Pappas NA 1988: Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev Ind Pharm 14: 283-318 <>
4. Erjavec V, Pavlica Z, Sentjurc M, Petelin M 2006: In vivo study of liposomes as drug carriers to oral mucosa using EPR oximetry. Int J Pharm 307: 1-8 <>
5. Gonzalez-Garcia A, Diniz-Freitas M, Gandara-Vila P, Blanco-Carrion A, Garcia-Garcia A, Gandara-Rey J 2006: Triamcinolone acetonide mouth rinses for treatment of erosive oral lichen planus: efficacy and risk of fungal over–infection. Oral Dis 12: 559-565 <>
6. Gonzalez-Moles MA 2010: The use of topical corticoids in oral pathology. Med Oral Patol Oral Cir Bucal 15: e827-e8231 <>
7. Gonzalez-Moles MA, Morales-Garcia P, Rodriguez-Archilla A 2002a: Clobetasol mouthwash is effective for severe oral erosive lesions. Dent Abstr 47: 268
8. Gonzalez-Moles MA, Morales P, Rodriguez-Archilla A, Isabel IR, Gonzalez-Moles S 2002b: Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93: 264-270 <>
9. Gonzalez-Moles MA, Ruiz-Avila I, Rodriguez-Archilla A, Morales-Garcia P, Mesa-Aguado F, Bascones-Martinez A, Bravo M 2003: Treatment of severe erosive gingival lesions by topical application of clobetasol propionate in custom trays. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95: 688-692 <>
10. Gonzalez-Moles MA, Scully C 2005a: Vesiculo-erosive oral mucosal disease management with topical corticosteroids: (1) fundamental principles and specific agents available. J Dent Res 84: 294-301 <>
11. Gonzalez-Moles MA, Scully C 2005b: Vesiculo-erosive oral mucosal disease management with topical corticosteroids: (2) Protocols, monitoring of effects and adverse reactions, and the future. J Dent Res 84: 302-308 <>
12. Haffajee AD, Socransky SS 1994: Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 5: 78-111 <>
13. Harsanyi BB, Hilchie JC, Mezei M 1986. Liposomes as drug carriers for oral ulcers. J Dent Res 65: 1133-1141 <>
14. Keklikoglu N, Koray M, Kocaelli H, Akinci S 2008: iNOS expression in oral and gastrointestinal tract mucosa. Dig Dis Sci 53: 1437-1442 <>
15. Kristl J, Abramovic Z, Sentjurc M 2003: Skin oxygenation after topical application of liposome–entrapped benzyl nicotinate as measured by EPR oximetry in vivo: influence of composition and size. AAPS Pharm Sci 5: 19-27 <>
16. Krzic M, Sentjurc M, Kristl J 2001: Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo. J Control Release 70: 203-211 <>
17. Lappin DF, Kjeldsen M, Sander L, Kinane DF 2000: Inducible nitric oxide synthase expression in periodontitis. J Periodontal Res 35: 369-373 <>
18. Little JW, Miller CS, Rhodus NL, Falace D (Eds) 2002: Dental Management of the Medically Compromised Patient. 6th edn. St. Louis, Mosby.
19. Lohinai Z, Benedek P, Fehér E, Györfi A, Rosivall L, Fazekas A, Salzman AL, Szabó C 1998: Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature–induced periodontitis in the rat. Br J Pharmacol. 123: 353-360. Erratum in: Br J Pharmacol 123: 741 <>
20. Lohinai Z, Stachlewitz R, Virag L, Szekely AD, Hasko G, Szabó C 2001: Evidence for reactive nitrogen species formation in the gingivomucosal tissue. J Dent Res 80: 470-475 <>
21. Lozada-Nur F, Huang MZ, Zhou GA 1991: Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol 71: 283-287 <>
22. Lozada-Nur F, Miranda C 1997: Oral lichen planus: topical and systemic therapy. Semin Cutan Med Surg 16: 295-300 <>
23. Lozada-Nur F, Miranda C, Maliksi R 1994: Double-blind clinical trial of 0.05% clobetasol propionate ointment in orabase and 0.05% fluocinonide ointment in orabase in the treatment of patients with oral vesiculoerosive diseases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 77: 598-604 <>
24. Lozada F, Silverman S Jr, Migliorati C 1984. Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases. J Am Dent Assoc 109: 269-270 <>
25. Mazei M, Gulasekharam V 1982: Liposomes: a selective drug delivery system for the topical route of administration. Gel dosage form. J Pharm Pharmacol 34: 473-474 <>
26. Moncada S, Higgs A 1993. The L-arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012
27. Nicolazzo JA, Reed BL, Finnin BC 2005: Enhancing the buccal mucosal uptake and retention of triamcinolone acetonide. J Control Release 105: 240-248 <>
28. Petelin M, Sentjurc M, Stolic Z, Skaleric U 1998: EPR study of mucoadhesive ointments for delivery of liposomes into the oral mucosa. Int J Pharm 173: 193-202 <>
29. Scully C, Beyli M, Ferreiro MC, Ficarra G, Gill Y, Griffiths M, Holmstrup P, Mutlu S, Porter S, Wray D 1998: Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med 9: 86-122 <>
30. Sentjurc M, Vrhovnik K, Kristl J 1999: Liposomes as a topical delivery system: the role of size on transport studied by the EPR imaging method. J Control Release 59: 87-97 <>
31. Streeten DH, Phil D 1975: Corticosteroid therapy. J Am Med Assoc 232: 944-948 <>
32. Sveinsson SJ, Holbrook WP 1993: Oral mucosal adhesive ointment containing liposomal corticosteroid. Int J Pharm 95: 105-109 <>
33. Ten Cate AR 1998: Oral histology: development, structure, and function. St. Louis: Mosby Year Book, pp. 345-385
34. Teng YT 2003: The role of acquired immunity and periodontal disease progression. Crit Res Oral Biol Med 14: 237-252 <>
35. Thorburn DN, Ferguson MM 1994: Topical corticosteroids and lesions of the oral mucosa. Adv Drug Delivery Rev 13: 135-149 <>
36. Vincent SD, Baker KA, Williams TP 1990: Oral lichen planus: the clinical, historical, and therapeutic features of 100 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 70: 165-171 <>
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