Acta Vet. Brno 2019, 88: 257-264

The effect of thyroid hormone deficiency on erythropoiesis in dogs

Olga Aniołek

Lazarski University, Warsaw, Poland

Received July 20, 2018
Accepted June 13, 2019


1. Campora C, Freeman KP, Lewis FI, Gibson G, Sacchini F, Sanchez-Vazquez MJ 2011: Determination of hematological reference intervals in healthy adult greyhounds. J Small Anim Pract 52: 301-309 <>
2. Das KC, Mukherjee M, Sarkar TK, Dash RJ, Rastogi GK 1975: Erythropoiesis and erythropoietin in hypo- and hyperthyroidism. J Clin Endocrinol Metab 40: 211-220 <>
3. den Elzen WP, de Craen AJ, Mooijaart SP, Gussekloo J 2015: Low thyroid function and anemia in old age: the Leiden 85-plus study. J Am Geriatr Soc 63: 407-409 <>
4. Dorgalaleh A, Mahmoodi M, Varmaghani B, Kiani Node F, Saeeidi Kia O 2013: Effect of thyroid dysfunctions on blood cell count and red blood cell indice. Iran J Ped Hematol Oncol 3: 73-77
5. Fandrey J, Pagel H, Frede S, Wolff M, Jelkmann W 1994: Thyroid hormones enhance hypoxia-induced erythropoietin production in vitro. Exp Hematol 22: 272-277
6. Gianoukakis AG, Leigh MJ, Richards P, Christenson PD, Hakimian A 2009: Characterization of the anaemia associated with Graves’ disease. Clin Endocrinol 70: 781-787 <>
7. Golde DW, Bersch N, Chopra IJ, Cline MJ 1977: Thyroid hormones stimulate erythropoiesis in vitro. Br J Haematol 37: 173-177 <>
8. Gosselin SJ, Capen CC, Martin SL 1980: Biochemical and immunogical investigations on hypothyroidism in dogs. Can J of Comp Med 44: 158-168
9. Guyton AC, Hall JE 2006: Textbook of Medical Physiology. 11th edn. Philadelphia, Elsevier Saunders, pp. 419-438
10. Kaneko JJ, Harvey JW, Bruss ML 2008: Appendix IX: blood analyte reference values in small and some laboratory animals. In: Kaneko JJ, Harvey JW, Bruss ML (eds): Clinical Biochemistry of Domestic Animals. 6th edn. San Diego, pp. 889-895
11. Khatiwada S, Gelal B, Baral N, Lamsal M 2016: Association between iron status and thyroid function in Nepalese children. Thyroid Res 9: 2 <>
12. Larsson M, Pettersson T 1987: Purification and partial characterization of thyroid hormone binding proteins in canine serum. Domest Anim Endocrinol 4: 215-229 <>
13. Maede Y, Inaba M, Taniguchi N 1983: Increase of Na-K-ATPase activity, glutamate, and aspartate uptake in dog erythrocytes associated with hereditary high accumulation of GSH, glutamate, glutamine, and aspartate. Blood 61: 493-499
14. Malgor LA, Blanc CC, Klainer E, Irizar SE, Torales PR 1975: Direct effects of thyroid hormones on bone marrow erythroid cells of rats. Blood 45: 671-679
15. Malgor LA, Valsecia ME, Verges EG, de Markowsky EE 1995: Enhancement of erythroid colony growth by triiodothyronine in cell cultures from bone marrow of normal and anemic rats with chronic renal failure. Acta Physiol Pharmacol Ther Latinoam 45: 79-86
16. Omar S, Hadj Taeib S, Kanoun F, Hammami MB, Kamoun S 2010: Erythrocyte abnormalities in thyroid dysfunction. Tunis Med 88: 783-788
17. Peterson ME, Ferguson DC 1989: Thyroid diseases. In: Ettinger SJ (Ed.): Textbook of Veterinary Internal Medicine. Philadelphia, WB Saunders, pp. 1632-1675
18. Porter JA Jr, Canaday WR Jr. 1971: Hematologic values in mongrel and greyhound dogs being screened for research use. J Am Vet Ned Assoc 159: 1603-1606
19. Refaat B 2015: Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study. Biomed J 38: 307-316 <>
20. Rijnberg A, Kooistra HS (2010) Clinical Endocrinology of Dogs and Cats, an Illustrated Text. 2nd edn. Schlütersche Verlagsgesellschaft, Hannover, pp. 55-91
21. Sullivan PS, Evans HL, McDonalds TP 1994: Platelet concentration and hemoglobin function in greyhounds. J Am Vet Med Assoc 205: 838-841
22. Szczepanek-Parulska E, Hernik A, Ruchala M 2017: Anemia in thyroid diseases. Pol Arch Intern Med 127: 352-360
23. Taylor S, Rampton D 2015: Treatment of iron deficiency anemia: practical considerations. Pol Arch Med Wewn 125: 452-460
24. Torres AR, Cassle SE, Haymore M, Hill RC 2014: Hematologic differences between Dachshunds and mixed breed dogs. Vet Clin Path 43: 519-524 <>
25. Vitale G, Fatti LM, Prolo S, Girola A, Caraglia M 2010: Screening for hypothyroidism in older hospitalized patients with anemia: a new insight into an old disease. J Am Geriatr Soc 58: 1825-1827 <>
26. Wilson GR, Curry RW, Jr 2005: Subclinical thyroid disease. Am Fam Physician 72: 1517-1524
27. Zaldivar-Lopez S, Marin LM, Lazbik MC, Westendorf-Stingle N, Hensley S, Couto CG 2011: Clinical pathology of Greyhounds and other sighthounds. Vet Clin Pathol 40: 414-425 <>
28. Ziglioli V, Panciera DL, Troy GC, Monroe WE, Boes KM, Refsal KR 2017: Effects of levothyroxine administration and withdrawal on the hypothalamic-pituitary-thyroid axis in euthyroid dogs. J Vet Intern Med 31: 705-710 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue