Acta Vet. Brno 2020, 89: 201-208

https://doi.org/10.2754/avb202089020201

A microbiological multi-plate method to detect cephalosporin residues in milk

Pavlína Navrátilová, Jana Vyhnálková, Hana Zachovalová, Lenka Vorlová

University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Milk Hygiene and Technology, Brno, Czech Republic

Received January 13, 2020
Accepted April 30, 2020

References

1. Aidara-Kane A, Frederick JA, Conly JM, Minato Y, Silbergeld EK, McEwen SA, Collignon PJ and for the WHO Guideline Development Group 2018: World Health Organization (WHO) guidelines on use of medically important antimicrobials in food-producing animals. Antimicrob Resist Infect Control 7:7 <https://doi.org/10.1186/s13756-017-0294-9>
2. Bogaerts R, Wolf F 1980: A standardized method for the detection of residues of anti-bacterial substances in fresh meat - EEC (European Communities). Fleischwirtschaft 60: 667–675
3. Botsoglou NA, Fletouris DI 2001: Drug Residues in Foods: Pharmacology, Food Safety, and Analysis. Marcel Dekker, New York, 1194 p.
4. Commission Decision 2002/657/EC of 12 August 2002, implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. OJ L 221: 8-36
5. Commission Regulation (EU) No. 37/2010 of 22 December 2009: on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. OJ L 15: 1-72
6. Council Directive 96/23/EC of 29 April 1996 on measures to monitor certain substances and residues thereof in live animals and animal products and repealing Directives 85/358/EEC and 86/469/EEC and Decision 89/187/EEC and 91/664/EEC. OJ L 125: 10-32
7. European Medicines Agency 2008: Revised reflection paper on the use of 3rd and 4th generation cephalosporins in food producing animals in the European Union: development of resistance and impact on human and animal health. (EMEA/CVMP/SAGAM/81730/2006-Rev.1). Available at: www.ema.europa.eu/documents/scientific-guideline/revised-reflection-paper-use-third-fourth-generation-cephalosporins-food-producing-animals-european_en.pdf. Last modified February 18, 2008. Accessed July 11, 2019
8. European Medicines Agency 2012: Veterinary medicines and product data management. Referral procedure on veterinary medicinal products containing 3rd and 4th generation cephalosporins under Article 35 of Directive 2001/82/EC, as amended (EMA/253066/2012). Available at: www.ema.europa.eu/en/documents/referral/questions-answers-referral-procedure-veterinary-medicinal-products-containing-3rd-4th-generation_en.pdf. Last modified May 7, 2008. Accessed July 11, 2019
9. European Medicines Agency 2019: Answer to the request from the European Commission for updating the scientific advice on the impact on public health and animal health of the use of antibiotics in animals - Categorisation of antimicrobials (EMA/CVMP/CHMP/682198/2017). Available at: www.ema.europa.eu/en/documents/other/answer-request-european-commission-updating-scientific-advice-impact-public-health-animal-health-use_en.pdf. Last modified February 4, 2019. Accessed September 20, 2019
10. European Commission 2000: White Paper on Food Safety, Available at: www.ec.europa.eu/food/food/intro/white_paper_en.pdf. Accessed September 9, 2019.
11. Federation of Veterinarians of Europe (FVE) 2016: Antimicrobial use in food-producing animals. (FVE/016/DOC/ O10). Available at: www.ema.europa.eu/en/documents/report/annex-replies-efsa/ema-questions-useantimicrobials-food-producing-animals-eu-possible-measures-reduceantimicrobial_en.pdf. Last modified February 29, 2016. Accessed September 10, 2019
12. Gaudin V, Maris P, Fuselier R, Ribouchon JL, Cadieu N, Rault A 2004: Validation of a microbiological method: the STAR protocol, a five-plate test, for the screening of antibiotic residues in milk. Food Addit Contam 21: 422-433 <https://doi.org/10.1080/02652030410001667575>
13. Heeschen WH, Blüthgen A 1991: Veterinary drugs and pharmacologically active compounds. In: Monograph on Residues and Contaminants in Milk and Milk Products. IDF, Brusel, pp. 13-69
14. Kirbiš A 2006: Microbiological 5-plate screening method for detection of tetracyclines, aminoglycosides, cephalosporins and macrolides in milk. Slov Vet Res 43: 161-168
15. Mitchell JM, Griffiths MW, McEwen S A, McNab WB, Yee AJ 1998: Antimicrobial drug residues in milk and meat: cause, concerns, prevalence, regulations, tests, and test performance. J Food Protect 61: 742-756 <https://doi.org/10.4315/0362-028X-61.6.742>
16. Navrátilová P, Vyhnálková J, Vorlová L, Jeřábková J 2014: A plate diffusion method for detecting fluoroquinolone residues in raw cow’s milk. Czech J Food Sci 32: 260-264 <https://doi.org/10.17221/209/2013-CJFS>
17. Nouws JFM, Van Egmond H, Loeffen G, Schouten J, Keukens H, Smulders I, Stegeman H 1999: Suitability of the Charm HVS and a microbiological multiplate system for detection of residues in raw milk at EU maximum residue levels. Veterinary Quarterly 21: 21-27 <https://doi.org/10.1080/01652176.1999.9694986>
18. OIE 2018a: OIE annual report on antimicrobial agents intended for use in animals. OIE, Paris, 129 p.
19. OIE 2018b: OIE List of Antimicrobial Agents of Veterinary Importance. Available at: www.oie.int/fileadmin/Home/eng/Our_scientific_expertise/docs/pdf/AMR/A_OIE_List_antimicrobials_May2018.pdf. Last modified May, 2018. Accessed July 11, 2019
20. Pikkemaat MG 2009: Microbial screening methods for detection of antibiotic residues in slaughter animals. Anal Bioanal Chem 395: 893-905 <https://doi.org/10.1007/s00216-009-2841-6>
21. Regulation (EC) No. 470/2009 of the European Parliament and of the Council of 6 May 2009 laying down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal origin. OJ L 152: 11-22
22. Schwarz S, Kehrenberg C, Walsh TR 2001: Use of antimicrobial agents in veterinary medicine and food animal production. Int J Antimicrob Agents 17: 431-437 <https://doi.org/10.1016/S0924-8579(01)00297-7>
23. State Veterinary Administration (SVA) 2008: Methodology for determination of inhibitory substance residues in tissues, eggs, milk and food of animal origin. State Veterinary Institute Jihlava, Czech Republic: 14 p. (in Czech)
24. WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR) 2017: Critically Important Antimicrobials for Human Medicine. Ranking of Medically Important Antimicrobials for Risk Management of Antimicrobial Resistance due to Non-Human Use. 5th revision 2016, Geneva, Switzerland, 41 p.
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Archive