Acta Vet. Brno 2020, 89: 283-290

Physiological influence of tylosin tartrate overdose in vivo in rats

JeongWoo Kang1, Akil Hossain1, Hae-chul Park1, Tae-wan Kim2, Sang-Hee Jeong3

1Veterinary drugs & Biologics Division, Animal and Plant Quarantine Agency (APQA), Gimcheon-si, Gyeongsangbuk-do, Republic of Korea
2Department of Physiology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
3GLP Research Center, College of Natural Sciences, Hoseo University, Asan City, Republic of Korea

Received November 13, 2019
Accepted June 22, 2020


1. Baba T, Yamashita N, Kodama H, Mukamoto M, Asada M, Nakamoto K, Nose Y, McGruder ED 1998a: Effect of tylosin tartrate (tylan soluble (R)) on cellular immune responses in chickens. Poult Sci 77: 1306-1311 <>
2. Baba T, Yamashita N, Kodama H, Mukamoto M, Asada M, Nakamoto K, Nose Y, McGruder ED 1998b: Effect of tylosin tartrate on humoral immune responses in chickens. J Vet Med B 45: 279-286 <>
3. Baek YO, Choi SK, Shin SH, Koo KH, Choi HY, Cha SB, Li YC, Yoo HJ, Lee JY, Kil KH, Kim HS, Kang MS, Kang BH, Kim KH, Bae JS 2012: A 6-week oral toxicity study of oral cholera vaccine in sprague-dawley rats. Toxicol Res 28: 225-233 <>
4. Baggesen DL, Wingstrand A, Carstensen B, Nielsen B, Aarestrup FM 1999: Effects of the antimicrobial growth promoter tylosin on subclinical infection of pigs with Salmonella enterica serotype Typhimuriumm. Am J Vet Res 60: 1201-1206
5. Beems RB, van Beek L 1985: Short-term (6-week) oral toxicity study of selenium in Syrian hamsters. Food Chem Toxicol 23: 945-947 <>
6. Bhaumik A, Verma BB, Thakur DK, Pandey SN, Banerjee NC 1990: Effect of oral-administration of tylosin tartrate in the treatment of experimental and natural cases of caprine mycoplasmosis. Indian Vet J 67: 948-951
7. Dorotheou D, Farsadaki V, Bochaton-Piallat ML, Giannopoulou C, Halazonetis TD, Kiliaridis S 2017: Increased cell proliferation and gene expression of genes related to bone remodeling, cell adhesion and collagen metabolism in the periodontal ligament of unopposed molars in growing rats. Front Physiol 8: 75 <>
8. Groelz D, Sobin L, Branton P, Compton C, Wyrich R, Rainen L 2013: Non-formalin fixative versus formalin-fixed tissue: A comparison of histology and RNA quality. Exp Mol Pathol 94: 188-194 <>
9. Hofmann JW, Zhao X, Cecco MD, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Remmen HV, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM 2015: Reduced expression of MYC increases longevity and enhances healthspan. Cell 160: 477-488 <>
10. JECFA - Joint FAO/WHO Expert Committee on Food Additives 2009: Toxicological evaluation of certain veterinary drug residues in food. World Health Organization, Geneva, WHO Technical Report Series: 954
11. Kilpinen S, Spillmann T, Syrjä P, Skrzypczak T, Louhelainen M, Westermarck E 2011: Effect of tylosin on dogs with suspected tylosin-responsive diarrhea: a placebo-controlled, randomized, double-blinded, prospective clinical trial. Acta Vet Scand 53: 26 <>
12. McOrist S, Morgan J, Veenhuizen MF, Lawrence K, Kroger HW 1997: Oral administration of tylosin phosphate for treatment and prevention of proliferative enteropathy in pigs. Am J Vet Res 58: 136-139
13. Meisel ML, Winterhoff H, Jekat FW 1993a: Effects of tylosin on the pituitary-gonadal axis in male rats. Basic Clin Pharmacol Toxicol 72: 336-340 <>
14. Meisel ML, Winterhoff H, Jekat FW 1993b: Tylosin inhibits the steroidogenesis in mouse leydig cells “in vitro”. Life Sci 53: 77-84 <>
15. Menozzi A, Pozzoli C, Poli E, Lazzaretti M, Cantoni A, Grandi D, Giovannini E, Coruzzi G 2005: Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat. Pharmacol 74: 135-142 <>
16. OECD - Organisation for Economic Co-operation and Development 1998: Guideline for the testing of chemicals. Repeated dose 90-days oral toxicity study in rodents, 408 p.
17. Ofem OE, Ani EJ, Eno AE 2012: Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats. Int J Appl Basic Med Res 2: 38-42 <>
18. Papich MG 2011: Saunders handbook of veterinary drugs small and large animal. 3rd edn. Elsevier Saunders, Missouri, 896 p.
19. Ramlachan N, Anderson RC, Andrews K, Harvey RB, Nisbet DJ 2008: A comparative study on the effects of tylosin on select bacteria during continuous flow culture of mixed populations of gut microflora derived from a feral and a domestic pig. Foodborne Pathog Dis 5: 21-31 <>
20. Satpal, Jain SK, Punia JS 2010: Studies on biochemical changes in subacute thiodicarb toxicity in rats. Toxicol Int 17: 30-32
21. Sellers RS, Morton D, Michael B, Roome N, Johnson JK, Yano BL, Perry R, Schafer K 2007: Society of toxicologic pathology position paper: organ weight recommendations for toxicology studies. Toxicol Pathol 35: 751-755 <>
22. Suchodolski JS, Dowd SE, Westermarck E, Steiner JM, Wolcott RD, Spillmann T, Harmoinen JA 2009: The effect of the macrolide antibiotic tylosin on microbial diversity in the canine small intestine as demonstrated by massive parallel 16S rRNA gene sequencing. BMC Microbiol 9: 210 <>
23. Vissiennon T, Kroger H, Kohler T, Kliche R 2000: Effect of avilamycin, tylosin and ionophore anticoccidials on Clostridium perfringens enterotoxaemia in chickens. Berl Muench Tieraerztl Wochenschr 113: 9-13
24. Yildiz S, Ozturkler Y, Uzun M, Kaya M, Ucar O 2004: Tylosin does not affect GnRH-induced LH secretion in rams. Reprod Toxicol 18: 131-134 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue