Acta Vet. Brno 2020, 89: 383-389

https://doi.org/10.2754/avb202089040383

The effect of capsaicin and diethylnitrosamine on mouse nephrotoxicity, hepatotoxicity and hepatocarcinogenesis

Vendula Kuchařová Kumžáková1, Ivana Veselá1, Miša Škorič2, Ondřej Daněk1, Kristína Řeháková3, Jaroslava Tomenendálová1

1University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Physiology, Brno, Czech Republic
2University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Veterinary Medicine, Department of Pathological Morphology and Parasitology, Brno, Czech Republic
3University of Veterinary and Pharmaceutical Sciences Brno, Clinic Laboratory for Small Animals, Faculty of Veterinary Medicine, Brno, Czech Republic

Received January 16, 2020
Accepted December 21, 2020

References

1. Bley K, Boorman G, Mohammad B, McKenzie D, Babbar S 2012: A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol 40: 847-873 <https://doi.org/10.1177/0192623312444471>
2. Chuang SE, Kuo ML, Hsu CH, Chen CR, Lin JK, Lai GM, Hsieh CY, Cheng AL 2000: Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis 21: 331-335 <https://doi.org/10.1093/carcin/21.2.331>
3. Da Costa RM, Santos NP, Rocha AF, Colaço A, Lopes C, Oliveira PA 2014: The N-nitrosodiethylamine mouse model: sketching a timeline of evolution of chemically-induced hepatic lesions. Anticancer Res 34: 7029-7037
4. Díaz Barriga Arceo S, Madrigal-Bujaidar E, Calderón Montellano E, Ramírez Herrera L, Díaz García BD 1995: Genotoxic effects produced by capsaicin in mouse during subchronic treatment. Mutat Res 345: 3-4 <https://doi.org/10.1016/0165-1218(95)90046-2>
5. Díaz-Laviada I, Rodríguez-Henche N 2014: The potential antitumor effects of capsaicin. Prog Drug Res 68: 181-208
6. Eldrige SR, Butterworth BE, Goldsworthy TL 1993: Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents. Environ Health Perspect 101: 211-218 <https://doi.org/10.1289/ehp.93101s5211>
7. Freund HA 1937: Clinical manifestation and studies in parenchymatous hepatitis. Ann Intern Med 10: 1144-1155
8. Ghouri YA, Mian I, Rowe JH 2017: Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis. J Carcinog 16: 1
9. Heindryckx F, Colle I, Van Vlierberghe H 2009: Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol 90: 367-386 <https://doi.org/10.1111/j.1365-2613.2009.00656.x>
10. Hu QX, Ottestad-Hansen S, Holmseth S, Hassel B, Danbolt NC, Zhou Y 2018: Expression of glutamate transporters in mouse liver, kidney, and intestine. J Histochem Cytochem 66: 189-202 <https://doi.org/10.1369/0022155417749828>
11. Jang JJ, Kim SH 1988: The promoting effect of capsaicin on the development of diethylnicrosamine-initiated enzyme altered hepatic foci in male Sprague Dawley rats. J Korean Cancer Assoc 20: 1-8
12. Jang JJ, Cho KJ, Lee YS, Bae JH 1991: Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat. J Korean Med Sci 6: 31-36 <https://doi.org/10.3346/jkms.1991.6.1.31>
13. Kakehashi A, Ishii N, Okuno T, Fujioka M, Gi M, Wanibuchi H 2017: Enhanced susceptibility of Ogg1 mutant mice to multiorgan carcinogenesis. Int J Mol Sci 18: 1801 <https://doi.org/10.3390/ijms18081801>
14. Kang JS, Kang HG, Park YI, Lee H, Park K, Lee YS, Kim S, Ryu DY 2013: Expression of epithelial cell adhesion molecule and proliferating cell nuclear antigen in diethylnitrosamine-induced hepatocarcinogenesis in mice. Exp Ther Med 5: 138-142 <https://doi.org/10.3892/etm.2012.751>
15. Koehne de Gonzalez AK, Salomao MA, Lagana SM 2015: Current concepts in the immunohistochemical evaluation of liver tumors. World J Hepatol 7: 1403-1411 <https://doi.org/10.4254/wjh.v7.i10.1403>
16. Kushida M, Kamendulis LM, Peat TJ, Klaunig JE 2011: Dose-related induction of hepatic preneoplastic lesions by diethylnitrosamine in C57BL/6 mice. Toxicol Pathol 39: 776-786 <https://doi.org/10.1177/0192623311409596>
17. Malvezzi M, Carioli G, Bertuccio P, Boffetta P, Levi F, La Vecchia C, Negri E 2017: European cancer mortality predictions for the year 2017, with focus on lung cancer. Ann Oncol 28: 1117-1123 <https://doi.org/10.1093/annonc/mdx033>
18. Mohammed FZ, Sultan AS, Abas AM 2014: Chemopreventive and therapeutic effect of capsaicin against diethylnitrosamine induced liver injury and hepatocellular carcinoma in rats. Int J Biol Pharm Res 5: 630-642
19. Mun KS, Cheah PL, Baharudin NB, Looi LM 2006: Proliferating cell nuclear antigen (PCNA) activity in hepatocellular carcinoma, benign peri-neoplastic and normal liver. Malays J Pathol 28: 73-77
20. Ojanguren I, Ariza A, Llatjós M, Castellà E, Mate JL, Navas-Palacios JJ 1993: Proliferating cell nuclear antigen expression in normal, regenerative, and neoplastic liver: a fine-needle aspiration cytology and biopsy study. Hum Pathol 24: 905-908 <https://doi.org/10.1016/0046-8177(93)90141-3>
21. Park SY, Jeong MS, Han CW, Yu HS, Jang SB 2016: Structural and functional insight into proliferating cell nuclear antigen. J Microbiol Biotechnol 26: 637-647 <https://doi.org/10.4014/jmb.1509.09051>
22. Pashmforoosh M, Rezaie A, Haghi-Karamallah M, Fazlara A, Shahriari A, Najafzadeh H 2015: Effects of caffeine on renal toxicity induced by diethylnitrosamine. Zahedan J Res Med Sci 17: 7-9
23. Rezaie A, Fazlara A, Haghi Karamolah M, Shahriari A, Najaf Zadeh H, Pashmforosh M 2013: Effects of Echinacea purpurea on hepatic and renal toxicity induced by diethylnitrosamine in rats. Jundishapur J Nat Pharm Prod 8: 60-64 <https://doi.org/10.5812/jjnpp.9686>
24. Santos NP, Pereira IC, Pires MJ, Lopes C, Andrade R, Oliveira MM, Colaço A, Peixoto F, Oliveira PA 2012: Histology, bioenergetics and oxidative stress in mouse liver exposed to N-diethylnitrosamine. In Vivo 26: 921-929
25. Santos NP, Colaço A, Gil da Costa RM, Oliveira MM, Peixoto F, Oliveira PA 2014: N-diethylnitrosamine mouse hepatotoxicity: time-related effects on histology and oxidative stress. Exp Toxicol Pathol 66: 429-436 <https://doi.org/10.1016/j.etp.2014.07.002>
26. Schneider C, Teufel A, Yevsa T, Staib F, Hohmeyer A, Walenda G, Zimmermann HW, Vucur M, Huss S, Gassler N, Wasmuth HE, Lira SA, Zender L, Luedde T, Trautwein C, Tacke F 2012: Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer. Gut 61: 1733-1743 <https://doi.org/10.1136/gutjnl-2011-301116>
27. Seitz HK, Stickel F 2006: Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol Chem 387: 349-360 <https://doi.org/10.1515/BC.2006.047>
28. Sharma SK, Vij AS, Sharma M 2013: Mechanisms and clinical uses of capsaicin. Eur J Pharmacol 720: 55-62 <https://doi.org/10.1016/j.ejphar.2013.10.053>
29. Siegel RL, Miller KD, Jemal A 2017: Cancer statistics, 2017. CA Cancer J Clin 67: 7-30 <https://doi.org/10.3322/caac.21387>
30. Smith DD Jr, Campbell JW 1988: Distribution of glutamine synthetase and carbamoyl-phosphate synthetase I in vertebrate liver. Proc Natl Acad Sci USA 85: 160-164 <https://doi.org/10.1073/pnas.85.1.160>
31. Stewart BW, Wild CP 2014: World cancer report 2014. Lyon, France: International Agency for Research on Cancer
32. Stuver S, Trichopoulos D 2008: Cancer of the liver and biliary tract. In: Adami HO, Hunter DJ, Trichopoulos D (Eds.): Textbook of Cancer Epidemiology. Oxford University Press, New York, pp. 308-332
33. Sun H, Yu L, Wei H, Liu G 2012: A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. J Biomed Biotechnol 2012: 584728
34. Tolba R, Kraus T, Liedtke C, Schwarz M, Weiskirchen R 2015: Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Lab Anim 49: 59-69 <https://doi.org/10.1177/0023677215570086>
35. Toyoda-Hokaiwado N, Yasui Y, Takamune M, Yamada M, Muramatsu M, Masumura K, Ohta T, Tanaka T, Nohmi T 2011: Modulatory effects of capsaicin on N-diethylnitrosamine (DEN)-induced mutagenesis in Salmonella typhimurium YG7108 and DEN-induced hepatocarcinogenesis in gpt delta transgenic rats. Genes and Environment 33: 160-166 <https://doi.org/10.3123/jemsge.33.160>
36. Veselá I, Celá Kolísková P, Kuchařová V, Tomenendálová J, Kováčová V, Pikula J, Repková B, Rapekta P, Hrouzek P, Cheel J, Doubek J 2018: Cytotoxic effect of aeruginosin-865, resveratrol and capsaicin on mouse fibroblasts and cells derived from fallow deer. Nat Prod Commun 13: 205-208
37. Wang B, Fu J, Yu T, Xu A, Qin W, Yang Z, Chen Y, Wang H 2018: Contradictory effects of mitochondria- and non-mitochondria-targeted antioxidants on hepatocarcinogenesis by altering DNA repair in mice. Hepatology 67: 623-635 <https://doi.org/10.1002/hep.29518>
38. Wasfy RE, Shams Eldeen AA 2015: Roles of combined glypican-3 and glutamine synthetase in differential diagnosis of hepatocellular lesions. Asian Pac J Cancer Prev 16: 4769-4775 <https://doi.org/10.7314/APJCP.2015.16.11.4769>
39. WHO 2018: Cancer. Available at: www.who.int/mediacentre/factsheets/fs297/en/. Last modified September 12, 2018
40. Zhang DY, Friedman SL 2012: Fibrosis-dependent mechanisms of hepatocarcinogenesis. Hepatology 56: 769-775 <https://doi.org/10.1002/hep.25670>
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