Acta Vet. Brno 2020, 89: 391-400

https://doi.org/10.2754/avb202089040391

Anti-ulcerogenic effect of osajin on indomethacin-induced gastric damage in rats

Huseyin Serkan Erol1, Ahmet Cakir2, Murat Koc3, Serkan Yildirim4, Mesut Halici5

1Kastamonu University, Faculty of Veterinary Medicine, Department of Biochemistry, Kastamonu, Turkey
2Kilis 7 Aralik University, Faculty of Science and Art, Department of Chemistry, Kilis, Turkey
3Ankara Yildirim Beyazit University, Public Health Institute, Department of Traditional, Complementary and Integrative Medicine, Ankara, Turkey
4Ataturk University, Faculty of Veterinary Medicine, Department of Pathology, Erzurum, Turkey
5Ataturk University, Faculty of Veterinary Medicine, Department of Biochemistry, Erzurum, Turkey

Received December 2, 2019
Accepted December 21, 2020

References

1. Abbas AM, Sakr HF 2013: Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. J Physiol Biochem 69: 527-537 <https://doi.org/10.1007/s13105-013-0241-z>
2. Aebi H 1984: Catalase in vitro. Methods Enzymol 105: 121-126 <https://doi.org/10.1016/S0076-6879(84)05016-3>
3. Atalay F, Odabasoglu F, Halici M, Cakir A, Cadirci E, Aslan A, Aydin Berktas O, Kazaz C 2015: Gastroprotective and antioxidant effects of Lobaria pulmonaria and its metabolite rhizonyl alcohol on indomethacin-induced gastric ulcer. Chem Biodivers 12: 1756-1767 <https://doi.org/10.1002/cbdv.201400432>
4. Bartošíková L, Nečas J, Suchý V, Janoštíková E, Bartošík T, Juřica J, Florian T, Klusakova J, Frydrych M 2006: Protective effects of osajin in ischemia-reperfusion of laboratory rat kidney. Pharmazie 61: 552-555
5. Bayir Y, Odabasoglu F, Cakir A, Aslan A, Suleyman H, Halici M, Kazaz C 2006: The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid. Phytomedicine 13: 584-590 <https://doi.org/10.1016/j.phymed.2005.07.002>
6. Bozkurt İ, Dilek E, Erol HS, Çakir A, Hamzaoğlu E, Koç M, Keleş ON, Halici MB 2017: Investigation on the effects of pomiferin from Maclura pomifera on indomethacin-induced gastric ulcer: An experimental study in rats. Med Chem Res 26: 2048-2056 <https://doi.org/10.1007/s00044-017-1913-y>
7. Chattopadhyay I, Bandyopadhyay U, Biswas K, Maity P, Banerjee RK 2006: Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radic Biol Med 40: 1397-1408 <https://doi.org/10.1016/j.freeradbiomed.2005.12.016>
8. Cigsar G, Keles ON, Can S, Karaca M, Can I, Erol HS, Sagir D, Abuc OO, Cakir A, Sahin ZG, Unal B, Anil B, Halici MB 2015: The protective effects of osajin on ischemia/reperfusion injury to rat ovaries: biochemical and histopathological evaluation. Kafkas Univ Vet Fak Derg 21: 753-760
9. Conaghan PG 2012: A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatol Int 32: 1491-1502 <https://doi.org/10.1007/s00296-011-2263-6>
10. Dengiz GO, Odabasoglu F, Halici Z, Suleyman H, Cadirci E, Bayir Y 2007: Gastroprotective and antioxidant effects of amiodarone on indomethacin-induced gastric ulcers in rats. Arch Pharm Res 30: 1426 <https://doi.org/10.1007/BF02977367>
11. Diopan V, Babula P, Shestivska V, Adam V, Zemlicka M, Dvorska M, Hubalek J, Trnkova L, Havel L, Kizek R 2008: Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide. J Pharm Biomed Anal 48: 127-133 <https://doi.org/10.1016/j.jpba.2008.05.025>
12. Florian T, Necas J, Bartosikova L, Klusakova J, Suchy V, El Naggar BE, Janostikova E, Bartosik T 2006: Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 150: 93-100 <https://doi.org/10.5507/bp.2006.013>
13. Halici M, Kufrevioglu OI, Odabasoglu F, Halici Z, Cakir A, Aslan A 2011: The ethanol–water extract of Ramalina capitata has gastroprotective and antioxidative properties: an experimental study in rats with indomethacin-induced gastric injuries. J Food Biochem 35: 11-26 <https://doi.org/10.1111/j.1745-4514.2010.00363.x>
14. Halici M, Odabasoglu F, Suleyman H, Cakir A, Aslan A, Bayir Y 2005: Effects of water extract of Usnea longissima on antioxidant enzyme activity and mucosal damage caused by indomethacin in rats. Phytomedicine 12: 656-662 <https://doi.org/10.1016/j.phymed.2004.06.021>
15. Jia Y-T, Ma B, Wei W, Xu Y, Wang Y, Tang H-T, Xia Z-F 2007: Sustained activation of nuclear factor-κB by reactive oxygen species is involved in the pathogenesis of stress-induced gastric damage in rats. Crit Care Med 35: 1582-1591 <https://doi.org/10.1097/01.CCM.0000266824.82280.17>
16. Kaplan KA, Odabasoglu F, Halici Z, Halici M, Cadirci E, Atalay F, Aydin O, Cakir A 2012: Alpha-lipoic acid protects against indomethacin-induced gastric oxidative toxicity by modulating antioxidant system. J Food Sci 77: H224-H230 <https://doi.org/10.1111/j.1750-3841.2012.02920.x>
17. Kim J-E, Heo Y-S, Lee KW 2017: Osajin inhibits solar UV-induced cyclooxygenase-2 expression through direct inhibition of RSK2. J Cell Biochem 118: 4080-4087 <https://doi.org/10.1002/jcb.26063>
18. Laine L 2016: Upper gastrointestinal bleeding due to a peptic ulcer. New Engl J Med 374: 2367-2376 <https://doi.org/10.1056/NEJMcp1514257>
19. Matsui H, Shimokawa O, Kaneko T, Nagano Y, Rai K, Hyodo I 2011: The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine. J Clin Biochem Nutr 48: 107-111 <https://doi.org/10.3164/jcbn.10-79>
20. Morsy MA, Ashour OM, Fouad AA, Abdel-Gaber SA 2010: Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. Clin Exp Pharmacol Physiol 37: 173-177 <https://doi.org/10.1111/j.1440-1681.2009.05250.x>
21. Musumba C, Pritchard D, Pirmohamed M 2009: Cellular and molecular mechanisms of NSAID-induced peptic ulcers. Aliment Pharmacol Ther 30: 517-531 <https://doi.org/10.1111/j.1365-2036.2009.04086.x>
22. Odabasoglu F, Cakir A, Suleyman H, Aslan A, Bayir Y, Halici M, Kazaz C 2006: Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J Ethnopharmacol 103: 59-65 <https://doi.org/10.1016/j.jep.2005.06.043>
23. Odabasoglu F, Halici Z, Cakir A, Halici M, Aygun H, Suleyman H, Cadirci E, Atalay F 2008: Beneficial effects of vegetable oils (corn, olive and sunflower oils) and α-tocopherol on anti-inflammatory and gastrointestinal profiles of indomethacin in rats. Eur J Pharmacol 591: 300-306 <https://doi.org/10.1016/j.ejphar.2008.06.075>
24. Ohkawa H, Ohishi N, Yagi K 1979: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358 <https://doi.org/10.1016/0003-2697(79)90738-3>
25. Pandır D, Per S, Doğanyiğit Z, Bekdemir FO, Gök G, Demirbağ A 2019: All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite. Turk J Zool 43: 566-579 <https://doi.org/10.3906/zoo-1907-15>
26. Rainsford KD 1988: Gastrointestinal damage from nonsteroidal anti-inflammatory drugs. Toxicol Pathol 16: 251-259 <https://doi.org/10.1177/019262338801600218>
27. Sedlak J, Lindsay RH 1968: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem 25: 192-205 <https://doi.org/10.1016/0003-2697(68)90092-4>
28. Sivalingam N, Basivireddy J, Balasubramanian KA, Jacob M 2008: Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. Arch Toxicol 82: 471-481 <https://doi.org/10.1007/s00204-007-0263-9>
29. Slater T, Cheeseman K, Davies M, Proudfoot K, Xin W 1987: Free radical mechanisms in relation to tissue injury. Proc Nutr Soc 46: 1-12 <https://doi.org/10.1079/PNS19870003>
30. Sun Y, Oberley LW, Li Y 1988: A simple method for clinical assay of superoxide dismutase. Clin Chem 34: 497-500 <https://doi.org/10.1093/clinchem/34.3.497>
31. Wang T, Zhao S, Wang Y, Yang Y, Yao L, Chu L, Du H, Fu F 2014: Protective effects of escin against indomethacin-induced gastric ulcer in mice. Toxicol Mech Methods 24: 560-566 <https://doi.org/10.3109/15376516.2014.951815>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Archive