Acta Vet. Brno 2021, 90: 179-183

Primary soft tissue angiomyolipoma in a dog with unusual clinical features

Jiří Lenz1,2,3, Petra Konečná2, František Tichý2, Luděk Fiala1,4

1Cytohisto s.r.o., Břeclav, Czech Republic
2University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Department of Anatomy, Histology and Embryology, Brno, Czech Republic
3Znojmo Hospital, Department of Pathology, Znojmo, Czech Republic
4Charles University Prague, First Faculty od Medicine, Prague, Czech Republic

Received October 24, 2020
Accepted May 26, 2021

Angiomyolipoma is an extremely rare neoplasm in animals. It belongs to a group of perivascular epithelioid cell tumours (so-called PEComas). This study reports a case of primary soft tissue angiomyolipoma in a dog with some unusual clinical features. A 4-year old female Labrador dog with a rapidly growing pelvic tumour measuring 30 × 20 cm with a short history of 12 weeks was presented. The tumour was well-circumscribed and pushed into the right vaginal wall and into the perineum. The tumour was completely surgically excised. An extensive histological examination was performed, including immunohistochemical analysis. Histology revealed a mesenchymal neoplasm consisting of three tissue components – mature adipose tissue (which dominated), vessels, and smooth muscle (spindle) cells. The lesion showed positive immunohistochemical staining with smooth muscle actin and desmin in mature-appearing smooth muscle cells and S-100 protein positivity in adipocytes. The diagnosis of angiomyolipoma must be considered in different types of benign and malignant tumours of various lineages. The diagnostic approach to soft tissue tumours, including angiomyolipoma, requires optimal processing and sectioning of resected specimens. This paper is believed to be the first case of primary soft tissue angiomyolipoma reported in the veterinary literature.


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