Acta Vet. Brno 2021, 90: 207-210

Hyperplastic and atrophic changes in the genital tract of a female cat following repeated treatment with deslorelin acetate – a case report

Gabriele Marino1, Cecilia Vullo2, Stefania Di Giorgio1, Antonina Zanghì1, Giuseppe Catone1, Alessandra Sfacteria1

1University of Messina, Department of Veterinary Sciences, Messina, Italy
2University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina, Italy

Received December 19, 2020
Accepted May 26, 2021


1. Ackermann CL, Volpato R, Destro FC, Trevisol E, Ruas Sousa N, Guaitolini CRF, Derussi AAP, Rascado TS, Lopes MD 2012: Ovarian activity reversibility after the use of deslorelin acetate as a short-term contraceptive in domestic queens. Theriogenology 78: 817-822 <>
2. Furthner E, Roos J, Niewiadomska Z, Maenhoudt C, Fontbonne A 2020: Contraceptive implants used by cat breeders in France: a study of 140 purebred cats. J Feline Med Surg 22: 984-992 <>
3. Goericke-Pesch S, Georgiev P, Atanasov A, Albouy M, Navarro C, Wehrend A 2013: Treatment of queens in estrus and after estrus with a GnRH-agonist implant containing 4.7 mg deslorelin; hormonal response, duration of efficacy, and reversibility. Theriogenology 79: 640-646 <>
4. Marino G, Rizzo S, Quartuccio M, Macrì F, Pagano G, Taormina A, Cristarella S, Zanghì A 2014: Deslorelin implants in pre-pubertal female dogs: short- and long-term effects on the genital tract. Reprod Dom Anim 49: 297-301 <>
5. Marino G, Quartuccio M, Sfacteria A, Cristarella S, Zanghì A 2019: Complete vaginal stenosis and hematocolpus in two bitches with a history of GnRH treatment to postpone puberty. J Hellenic Vet Med Soc 70: 1905-1910 <>
6. Munson L, Bauman J E, Asa CS, Jöchle W, Trigg TE 2001: Efficacy of the GnRH analogue deslorelin for suppression of oestrous cycles in cats. J Reprod Fertil Suppl. 57: 269-273
7. Pisu MC, Romagnoli S 2012: Application of a single deslorelin implant in cats. Veterinaria 26: 9-15
8. Theise B 2016: Cystic endometrial hyperplasia and leiomyoma following perennial treatment of a bitch with Deslorelin implant. Kleintierpraxis 61: 614-621
9. Toydemir TSF, Kılıçarslan MR, Olgaç V 2012: Effects of the GnRH analogue deslorelin implants on reproduction in female domestic cats. Theriogenology 77: 662-674 <>
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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