Acta Vet. Brno 2021, 90: 307-314

https://doi.org/10.2754/avb202190030307

Cytotoxic effect of Aeruginosin-865, capsaicin, and resveratrol on mouse cell lines of different origin

Ivana Veselá1, Jose Cheel2, Jaroslava Tomenendálová1, Pavla Hamouzová1, Pavel Hrouzek2, Šárka Stehlíková1, Kristína Řeháková3, Jaroslav Doubek1

1University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Department of Physiology, Brno, Czech Republic
2Czech Academy of Sciences (CAS) v.v.i., Institute of Microbiology, Centre Algatech, Třeboň, Czech Republic
3University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Clinic Laboratory for Small Animals, Brno, Czech Republic

Received September 4, 2020
Accepted August 31, 2021

References

1. Bley K, Boorman G, Mohammad B, McKenzie D, Babbar S 2012: A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol 40: 847-873 <https://doi.org/10.1177/0192623312444471>
2. Bu HQ, Cai K, Shen F, Bao XD, Xu Y, Yu F, Pan HQ, Chen CH, Du ZJ, Cui JH 2015: Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways. Neoplasma 62: 582-591 <https://doi.org/10.4149/neo_2015_070>
3. Chapa-Oliver AM, Mejía-Teniente L 2016: Capsaicin: from plants to a cancer-suppressing agent. Molecules 21: 931 <https://doi.org/10.3390/molecules21080931>
4. Clark R, Lee SH 2016: Anticancer properties of capsaicin against human cancer. Anticancer Res 36: 837-843
5. Faltermann S, Hutter S, Christen V, Hettich T, Fent K 2016: Anti-inflammatory activity of cyanobacterial serine protease inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in human hepatoma cell line Huh7 and effects in zebrafish (Danio rerio). Toxins 8: 219-233 <https://doi.org/10.3390/toxins8070219>
6. Ferraz da Costa DC, Fialho E, Silva JL 2017: Cancer chemoprevention by resveratrol: the p53 tumor suppressor protein as a promising molecular target. Molecules 22: 1014 <https://doi.org/10.3390/molecules22061014>
7. Galati G, O’Brien PJ 2003: Cytoprotective and anticancer properties of coenzyme Q versus capsaicin. Biofactors 18: 195-205 <https://doi.org/10.1002/biof.5520180222>
8. Ghosh AK, Basu S 2010: Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis. Cancer Lett 287: 142-149 <https://doi.org/10.1016/j.canlet.2009.06.007>
9. Gweon EJ, Kim SJ 2013: Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells. Oncol Rep 29: 826-834 <https://doi.org/10.3892/or.2012.2151>
10. Harati K, Slodnik P, Chromik AM, Goertz O, Hirsch T, Kapalschinski N, Klein-Hitpass L, Kolbenschlag J, Uhl W, Lehnhardt M, Daigeler A 2015: Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res 35: 767-774
11. Kapuścik A, Hrouzek P, Kuzma M, Bártová S, Novák P, Jokela J, Pflüger M, Eger A, Hundsberger H, Kopecký J 2013: Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chem Bio Chem 14: 2329-2337 <https://doi.org/10.1002/cbic.201300246>
12. Kim MY 2012: Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Rep 5: 585-591
13. Kim MY, Trudel LJ, Wogan GN 2009: Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res 29: 3733-3740
14. Lee SJ, Kim MM 2011: Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells. Life Sci 88: 465-472 <https://doi.org/10.1016/j.lfs.2011.01.005>
15. Lee JG, Yon JM, Lin C, Jung Y, Jung KY, Nam SY 2012: Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem Toxicol 50: 3877-3885 <https://doi.org/10.1016/j.fct.2012.08.040>
16. Lewinska A, Chochrek P, Smolag K, Rawska E, Wnuk M 2015: Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide. Redox Rep 20: 116-125 <https://doi.org/10.1179/1351000214Y.0000000113>
17. Reyes-Escogido M de L, Gonzalez-Mondragon EG, Vazquez-Tzompantzi E 2011: Chemical and pharmacological aspects of capsaicin. Molecules 16: 1253-1270 <https://doi.org/10.3390/molecules16021253>
18. Sharma SK, Vij AS, Sharma M 2013: Mechanisms and clinical uses of capsaicin. Eur J Pharmacol 720: 55-62 <https://doi.org/10.1016/j.ejphar.2013.10.053>
19. Varoni EM, Lo Faro AF, Sharifi-Rad J, Iriti M 2016: Anticancer molecular mechanisms of Resveratrol. Front Nutr 3: 8 <https://doi.org/10.3389/fnut.2016.00008>
20. Vendrely V, Amintas S, Noel C, Moranvillier I, Lamrissi I, Rousseau B, Coulibaly S, bedel A, Moreau-Gaudry F, Buscail E, Chiche L, Belleannée G, Dupin C, Dabernat S 2019: Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death. Cancer Lett 451: 1-10 <https://doi.org/10.1016/j.canlet.2019.02.038>
21. Vendrely V, Peuchant E, Buscail E, Moranvillier I, Rousseau B, Bedel A, Brillac A, de Verneuil H, Moreau-Gaudry F, Dabernat S 2017: Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. Cancer Lett 390: 91-102 <https://doi.org/10.1016/j.canlet.2017.01.002>
22. Veselá I, Celá-Kolísková P, Kuchařová V, Tomenendálová J, Kováčová V, Pikula J, Repková B, Rapekta P, Hrouzek P, Cheel J, Doubek J 2018: Cytotoxic effect of aeruginosin-865, resveratrol and capsaicin on mouse fibroblasts and cells derived from fallow deer. Nat Prod Commun 13: 205-208
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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