Acta Vet. Brno 2021, 90: 307-314
https://doi.org/10.2754/avb202190030307
    Cytotoxic effect of Aeruginosin-865, capsaicin, and resveratrol on mouse cell lines of different origin
References
1.  K, Boorman G, Mohammad B, McKenzie D, Babbar S 2012: A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol 40: 847-873
            <https://doi.org/10.1177/0192623312444471>
        
        
    
        2.  HQ, Cai K, Shen F, Bao XD, Xu Y, Yu F, Pan HQ, Chen CH, Du ZJ, Cui JH 2015: Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways. Neoplasma 62: 582-591
            <https://doi.org/10.4149/neo_2015_070>
        
        
    
        3.  AM, Mejía-Teniente L 2016: Capsaicin: from plants to a cancer-suppressing agent. Molecules 21: 931
            <https://doi.org/10.3390/molecules21080931>
        
        
    
        4.  R, Lee SH 2016: Anticancer properties of capsaicin against human cancer. Anticancer Res 36: 837-843
            
        
        
    
        5.  S, Hutter S, Christen V, Hettich T, Fent K 2016: Anti-inflammatory activity of cyanobacterial serine protease inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in human hepatoma cell line Huh7 and effects in zebrafish (Danio rerio). Toxins 8: 219-233
            <https://doi.org/10.3390/toxins8070219>
        
        
    
        6.  DC, Fialho E, Silva JL 2017: Cancer chemoprevention by resveratrol: the p53 tumor suppressor protein as a promising molecular target. Molecules 22: 1014
            <https://doi.org/10.3390/molecules22061014>
        
        
    
        7.  G, O’Brien PJ 2003: Cytoprotective and anticancer properties of coenzyme Q versus capsaicin. Biofactors 18: 195-205
            <https://doi.org/10.1002/biof.5520180222>
        
        
    
        8.  AK, Basu S 2010: Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis. Cancer Lett 287: 142-149
            <https://doi.org/10.1016/j.canlet.2009.06.007>
        
        
    
        9.  EJ, Kim SJ 2013: Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells. Oncol Rep 29: 826-834
            <https://doi.org/10.3892/or.2012.2151>
        
        
    
        10.  K, Slodnik P, Chromik AM, Goertz O, Hirsch T, Kapalschinski N, Klein-Hitpass L, Kolbenschlag J, Uhl W, Lehnhardt M, Daigeler A 2015: Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res 35: 767-774
            
        
        
    
        11.  A, Hrouzek P, Kuzma M, Bártová S, Novák P, Jokela J, Pflüger M, Eger A, Hundsberger H, Kopecký J 2013: Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chem Bio Chem 14: 2329-2337
            <https://doi.org/10.1002/cbic.201300246>
        
        
    
        12.  MY 2012: Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Rep 5: 585-591
            
        
        
    
        13.  MY, Trudel LJ, Wogan GN 2009: Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation. Anticancer Res 29: 3733-3740
            
        
        
    
        14.  SJ, Kim MM 2011: Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells. Life Sci 88: 465-472
            <https://doi.org/10.1016/j.lfs.2011.01.005>
        
        
    
        15.  JG, Yon JM, Lin C, Jung Y, Jung KY, Nam SY 2012: Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons. Food Chem Toxicol 50: 3877-3885
            <https://doi.org/10.1016/j.fct.2012.08.040>
        
        
    
        16.  A, Chochrek P, Smolag K, Rawska E, Wnuk M 2015: Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide. Redox Rep 20: 116-125
            <https://doi.org/10.1179/1351000214Y.0000000113>
        
        
    
        17.  M de L, Gonzalez-Mondragon EG, Vazquez-Tzompantzi E 2011: Chemical and pharmacological aspects of capsaicin. Molecules 16: 1253-1270
            <https://doi.org/10.3390/molecules16021253>
        
        
    
        18.  SK, Vij AS, Sharma M 2013: Mechanisms and clinical uses of capsaicin. Eur J Pharmacol 720: 55-62
            <https://doi.org/10.1016/j.ejphar.2013.10.053>
        
        
    
        19.  EM, Lo Faro AF, Sharifi-Rad J, Iriti M 2016: Anticancer molecular mechanisms of Resveratrol. Front Nutr 3: 8
            <https://doi.org/10.3389/fnut.2016.00008>
        
        
    
        20.  V, Amintas S, Noel C, Moranvillier I, Lamrissi I, Rousseau B, Coulibaly S, bedel A, Moreau-Gaudry F, Buscail E, Chiche L, Belleannée G, Dupin C, Dabernat S 2019: Combination treatment of resveratrol and capsaicin radiosensitizes pancreatic tumor cells by unbalancing DNA repair response to radiotherapy towards cell death. Cancer Lett 451: 1-10
            <https://doi.org/10.1016/j.canlet.2019.02.038>
        
        
    
        21.  V, Peuchant E, Buscail E, Moranvillier I, Rousseau B, Bedel A, Brillac A, de Verneuil H, Moreau-Gaudry F, Dabernat S 2017: Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. Cancer Lett 390: 91-102
            <https://doi.org/10.1016/j.canlet.2017.01.002>
        
        
    
        22.  I, Celá-Kolísková P, Kuchařová V, Tomenendálová J, Kováčová V, Pikula J, Repková B, Rapekta P, Hrouzek P, Cheel J, Doubek J 2018: Cytotoxic effect of aeruginosin-865, resveratrol and capsaicin on mouse fibroblasts and cells derived from fallow deer. Nat Prod Commun 13: 205-208
            
        
        
    
 
        
