Comparison of the effect of two anti-adhesion materials on the formation of postoperative adhesions after myomectomy – an experimental study on rabbit does

Pánková, Soňa; Nečasová, Andrea; Lorenzová, Jana; Jekl, Vladimír; Nečas, Alois; Dušek, Ladislav; Hudeček, Robert; Gál, Petr

doi:10.2754/avb202190040407

Acta Veterinaria > Archive > 2021, Vol. 90 > Issue 4 > Comparison of the effect of two…

Acta Vet. Brno 2021, 90: 407-414

https://doi.org/10.2754/avb202190040407

Comparison of the effect of two anti-adhesion materials on the formation of postoperative adhesions after myomectomy – an experimental study on rabbit does

Soňa Pánková¹, Andrea Nečasová², Jana Lorenzová², Vladimír Jekl³, Alois Nečas², Ladislav Dušek⁴, Robert Hudeček¹, Petr Gál⁵

¹Brno University Hospital and Masaryk University Medical School, Department of Obstetrics and Gynaecology, Brno, Czech Republic
²University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Department of Surgery & Orthopaedics, Small Animal Clinic, Brno, Czech Republic
³University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Department of Pharmacology and Pharmacy, Brno, Czech Republic
⁴Masaryk University, Faculty of Medicine, Institute of Biostatistics and Analyses, Brno, Czech Republic
⁵Masaryk University, Faculty of Medicine, Department of Pediatric Surgery, Orthopedics and Traumatology, Brno, Czech Republic

Received August 30, 2021
Accepted November 9, 2021

This study compares the effect of Hyalobarrier Gel and 4DryField® PH on the formation of postoperative adhesions after myomectomy in an experimental study on rabbit does. Thirty experimental animals were divided into three groups: group A – control, group B – use of 4DryField® PH, and group C – use of the Hyalobarrier Gel. A simulated myomectomy was performed in each group. The animals were euthanised 14 days after the procedure and the antiadhesive effect of the above-mentioned preparations was evaluated according to the criteria. Statistical evaluation clearly showed differences in the antiadhesive effect in the scoring systems for groups B and C compared to control group A at a high level of significance. We demonstrated an obvious, statistically confirmed antiadhesive effect of the Hyalobarrier Gel and 4DryField® PH in an experimental model of the rabbit uterus. Comparing both preparations, the Hyalobarrier Gel shows a higher level of effectiveness. Based on the results of the experiment, both preparations can be unambiguously recommended for routine practice.

Keywords

Lagomorpha, gynaecology, Hyalobarrier Gel, 4DryField® PH.

Funding

This experiment was conducted according to approved Experiment project no. 14-2021. This work was supported by the Internal Creative Agency of the University of Veterinary Sciences Brno project number 2021ITA13.