Acta Vet. Brno 2022, 91: 285-291

Poly(lactic-co-glycolic) acid nanoparticles as a delivery system for fish oil in wound healing

Tomáš Komprda1, Vendula Popelková1, Ludmila Košarišťanová2, Veronika Šmídová2

1Mendel University in Brno, Faculty of AgriSciences, Department of Food Technology, Brno, Czech Republic
2Mendel University in Brno, Faculty of AgriSciences, Department of Chemistry and Biochemistry, Brno, Czech Republic

Received November 3, 2021
Accepted June 14, 2022


1. Arantes EL, Dragano N, Ramalho A, Vitorino D, de Souza GF, Lima MH, Velloso MA, Araújo EP 2016: Topical docosahexaenoic acid (DHA) accelerates skin wound healing in rats and activates GPR120. Biol Res Nutr 18 411-419
2. Berthet M, Gauthier Y, Lacroix C, Verrier B, Monge C 2017: Nanoparticle-based dressing: The future of wound treatment? Trends Biotech 35: 770-784 <>
3. Cheng Y-H, Chang YF, Ko Y-C, Jui-ling Liu C 2021: Development of a dual delivery of levofloxacin and prednisolone acetate via PLGA nanoparticles/thermosensitive chitosan-based hydrogel for postoperative management: An in-vitro and ex-vivo study. Int J Biol Macromol 180: 365-374 <>
4. Giustina AD, de Souza Goldim MP, Gainski Danielski L, Garbossa L, Oliveira Junior AN, Cidreira T, Denico T, Bonfante S, da Rosa N, Fortunato JJ, Palandi J, Hoffmann de Oliveira B, Fernandes Martins D, Bobinski F, Garcez M, Bellettini-Santos T, Budni J, Colpo G, Scaini G, Giridharan VV, Barichello T, Petronilho F 2020: Lipoic acid and fish oil combination potentiates neuroinflammation and oxidative stress regulation and prevents cognitive decline of rats after sepsis. Mol Neurobiol 57: 4451-4466 <>
5. Han E-J, Chung A-H, Oh I-J 2012: Analysis of residual solvents in poly(lactide-co-glycolide) nanoparticles. J Pharm Investig 42: 251-256 <>
6. Hasan N, Cao J, Lee J, Hlaing SP, Oshi MA, Naeem M, Ki M-H, Lee BL, Jung Y, Yoo J-W 2019: Bacteria-targeted clindamycin loaded polymeric nanoparticles: Effect of surface charge on nanoparticle adhesion to MRSA, antibacterial activity, and wound healing. Pharmaceutics 11: 236 <>
7. Hashim AF, Hamed SF, Abdel Hamid HA, Abd-Elsalam KA, Golonka I, Musiał W, El-Sherbiny IL 2019: Antioxidant and antibacterial activities of omega-3 rich oils/curcumin nanoemulsions loaded in chitosan and alginate-based microbeads. Int J Biol Macromol 140: 682-696 <>
8. Kemme M, Heinzel-Wieland R 2018: Quantitative assessment of antimicrobial activity of PLGA films loaded with 4-hexylresorcinol. J Funct Biomat 9: 4 <>
9. Kendall AC, Kiezel-Tsugunova M, Brownbridge LC, Harwood JL, Nicolaou A 2017: Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model. Biochim Biophys Acta (BBA) – Biomembranes 1859 (Part B):1679-1689
10. Komprda T 2012: Eicosapentaenoic and docosahexaenoic acids as inflammation-modulating and lipid homeostasis influencing nutraceuticals: A review. J Funct Foods 4: 25-38 <>
11. Komprda T 2018: Effect of n-3 long-chain polyunsaturated fatty acids on wound healing using animal models – a review. Acta Vet Brno 87: 309-320 <>
12. Komprda,T, Sladek Z, Sevcikova Z, Svehlova V, Wijacki J, Guran R, Do T, Lackova Z, Polanska H, Vrlikova L, Popelkova V, Michalek P, Zitka O, Buchtova M 2020: Comparison of dietary oils with different polyunsaturated fatty acid n-3 and n-6 content in the rat model of cutaneous wound healing. Int J Mol Sci 21: 7911 <>
13. Liu E, Shao S, Li X, Meng X, Liu B 2021: Preparation, characterization of PLGA/chitosan nanoparticles as a delivery system for controlled release of DHA. Int J Biol Macromol 185: 782-791 <>
14. Meng FT, Ma GH, Qiu W, Su ZG 2003: W/O/W double emulsion technique using ethyl acetate as organic solvent: effects of its diffusion rate on the characteristics of microparticles. J Control Release 91:407-416 <>
15. Pettinelli N, Rodríguez-Llamazares S, Farrag,Y, Bouza R, Barral L, Feijoo-Bandín S, Lago F 2020: Poly(hydroxybutyrate-co-hydroxyvalerate) microparticles embedded in κ-carrageenan/locust bean gum hydrogel as a dual drug delivery carrier. Int J Biol Macromol 146: 110-118 <>
16. Rakotoarisoa, M, Angelov B, Garamus V, Angelova A 2019: Curcumin- and fish oil-loaded spongosome and cubosome nanoparticles with neuroprotective potential against H2O2-induced oxidative stress in differentiated human SH-SY5Y cells. ACS Omega 4: 3061-3073 <>
17. Son G-H, Lee BJ, Cho C-W 2017: Mechanisms of drug release from advanced drug formulations such as polymeric-based drug-delivery systems and lipid nanoparticles. J Pharm Investig 47: 287-296 <>
18. Yang J, Ciftci ON 2020: In vitro bioaccessibility of fish oil-loaded hollow solid lipid micro- and nanoparticles. Food Funct 11: 8637-7647 <>
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Indexed in DOAJ