Acta Vet. Brno 2023, 92: 133-138

Systemic lupus erythematosus in a dog treated for temporomandibular disorder – a case report

Jookyung Sung1, Yeon Chae1, Dohee Lee1, Yoonhoi Koo1, Taesik Yun1, Dongwoo Chang2, Kyung-Mee Park3, Mhan-Pyo Yang1, Byeong-Teck Kang1, Hakhyun Kim1

1Chungbuk National University, College of Veterinary Medicine, Laboratory of Veterinary Internal Medicine, Cheongju, Chungbuk, South Korea
2Chungbuk National University, College of Veterinary Medicine, Veterinary Teaching Hospital, Department of Veterinary Imaging, Cheongju, Chungbuk, South Korea
3Chungbuk National University, College of Veterinary Medicine, Department of Opthalmology and Surgery, Cheongju, Chungbuk, South Korea

Received September 3, 2022
Accepted May 4, 2023

A 7-year-old, castrated male, Dachshund dog initially presented with locked-jaw syndrome. Computed tomography and magnetic resonance imaging indicated bilateral lymphadenopathy, but no skeletal or joint disorder was suspected. The dog showed no evidence of masticatory muscle myositis in the masticatory muscle antibody test and histopathologic examination, indicating non-infectious inflammation. Temporomandibular disorder due to immune-mediated disease was suspected, and the symptoms improved following prednisolone treatment. One year later, the dog was referred with multiple joint swellings and fever. Based on radiographic findings, synovial fluid analysis, and positive results of the antinuclear antibody test, systemic lupus erythematosus was diagnosed. The previous temporomandibular disorder might have been caused by systemic lupus erythematosus showing typical characteristics of recurrence and instability of various musculoskeletal systems. The symptoms were also relieved by glucocorticoid treatment. This report describes a case of systemic lupus erythematosus in a dog that was previously treated for temporomandibular disease, implying that systemic lupus erythematosus might be a cause of temporomandibular disorder or the two diseases might be associated in dogs.


This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (No. NRF-2021R1F1A1061799).


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