Acta Vet. Brno 2024, 93: 11-18

https://doi.org/10.2754/avb202493010011

Correlation of histological grade and expression of adhesion molecules in canine mammary gland carcinomas

Marie Golis1, Jana Lorenzová2, Lucie Urbanová2, Aneta Angelová3, Barbora Moldovan Putnová3,4, Zita Filipejová1, Michal Crha1, Alois Nečas2

1University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Department of Internal Medicine, Brno, Czech Republic
2University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Department of Surgery and Orthopaedics, Brno, Czech Republic
3University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Department of Pathological Morphology and Parasitology, Brno, Czech Republic
4Czech Academy of Sciences, Institute of Molecular Morphogenesis, Brno, Czech Republic

Received January 20, 2023
Accepted February 19, 2024

References

1. Brunetti B, Sarli G, PreziosI R, Monari I, Benazzi C 2005: E-cadherin and beta-catenin reduction influence invasion but not proliferation and survival in canine malignant mammary tumors. Vet Pathol 42: 781-787 <https://doi.org/10.1354/vp.42-6-781>
2. Cammack R, Atwood T, Campbell P, Parish H, Smith A, Vella F, Stirling J 2011: Oxford Dictionary of Biochemistry and Molecular Biology. 2nd edn, Oxford University Press, 736 p.
3. Cassali GD, Lavalle GE, Ferreira E, Lime AE, De Nardi AB, Ghever C, Sobral RA, Amorim RL, Oliveira LO, Sueiro FAR, Beserra HEO, Bertagnolli AC, Gamba CO, Damasceno KA, Campos CB, Araujo MR, Campos LC, Monteiro LN, Nunes FC, Horta RS, Reis DC, Luvizotto MCR, Magalhăes GM, Raposo JB, Ferreira AMR, Tanaka NM, Grandi F, Ubukata R, Batschinski K, Terra EM, Salvador RCL, Jark PC, Delecrodi JER, Nascimento NA, Silva DN, Silva LP, Ferreira KCRS, Frehse MS, Di Santis GW, Silva EO, Guim TN, Kerr B, Cintra PP, Silva FBF, Leite JS, Mello MF V, Ferreira M De LG, Fukumasu H, Salgado BS, Torres R 2014: Consensus for the diagnosis, prognosis and treatment of canine mammary tumors - 2013. Braz J Vet Pathol 7: 38-69
4. Chon E, Thompson V, Schmid S, Stein TJ 2013: Activation of the canonical Wnt/β-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines. J Comp Pathol 148: 178-187 <https://doi.org/10.1016/j.jcpa.2012.07.001>
5. Ettinger SJ, Feldman EC 2010: Textbook of Veterinary Internal Medicine: Diseases of the Dog and the Cat. 7th edn, St. Louis. Missouri: Saunders Elsevier, 2218 p.
6. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Löchner D, Birchmeier W 1991: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113: 173-185 <https://doi.org/10.1083/jcb.113.1.173>
7. Furuya M, Funasaki M, Tani H, Sasai K 2015: Identification of novel tumour-associated antigens in canine mammary gland tumour. Vet Comp Oncol 13: 194-202 <https://doi.org/10.1111/vco.12034>
8. Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P, Quintanilla M, Cano A 1993: Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 142: 987-993
9. Goldschmidt M, Peńa L, Rasotto R, Zappulli V 2011: Classification and grading of canine mammary tumors. Vet Pathol 48: 117-131 <https://doi.org/10.1177/0300985810393258>
10. Gould Rothberg BE, Bracken MB 2006: E-cadherin immunohistochemical expression as a prognostic factor in infiltrating ductal carcinoma of the breast: a systematic review and meta-analysis. Breast Cancer Res Treat 100: 139-148 <https://doi.org/10.1007/s10549-006-9248-2>
11. Grigoryan T, Wend P, Klaus A, Birchmeier W 2008: Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev 22: 2308-2341 <https://doi.org/10.1101/gad.1686208>
12. Im K, Mareninov S, Diaz MFP, Yong WH 2019: An introduction to performing immunofluorescence staining. Methods Mol Biol 1897: 299-311 <https://doi.org/10.1007/978-1-4939-8935-5_26>
13. Kaszak I, Ruszczak A, Kanafa S, Kacprzak K, Król M, Jurka P 2018: Current biomarkers of canine mammary tumors. Acta Vet Scand 60: 66 <https://doi.org/10.1186/s13028-018-0417-1>
14. Knudsen KA, Wheelock MJ 2005: Cadherins and the mammary gland. J Cell Biochem 95: 488-496 <https://doi.org/10.1002/jcb.20419>
15. Lipponen PK, Collan Y 1992: Simple quantitation of immunohistochemical staining positivity in microscopy for histopathology routine. Acta stereol 11: 125-132
16. Luo Y, Li M, Zuo X, Basourakos SP, Zhang J, Zhao J, Han Y, Lin Y, Wang Y, Jiang Y, Lan L 2018: β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancer. Int J Oncol 52: 1827-1840
17. Matos AJ, Lopes C, Carvalheira J, Santos M, Rutteman GR, Gärtner F 2006: E-cadherin expression in canine malignant mammary tumours: relationship to other clinico-pathological variables. J Comp Patho 134: 182-189 <https://doi.org/10.1016/j.jcpa.2005.10.004>
18. Novosad AC 2003: Principles of treatment for mammary gland tumors. Clin Tech Small Anim Prac 18: 107-109 <https://doi.org/10.1053/svms.2003.36625>
19. Oka H, Shiozaki H, Kobayashi K, Inoue M, Tahara H, Kobayashi T, Takatsuka Y, Matsuyoshi N, Hirano S, Takeichi M 1993: Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 53: 1696-1701
20. Peña L, De Andrés, PJ, Clemente M, Cuesta P, Pérez-Alenza MD 2013: Prognostic value of histological grading in noninflammatory canine mammary carcinomas in a prospective study with two-year follow-up. Vet Pathol 50: 94-105 <https://doi.org/10.1177/0300985812447830>
21. Perez-Moreno M, Fuchs E 2006: Catenins: keeping cells from getting their signals crossed. Dev Cell 11: 601-612 <https://doi.org/10.1016/j.devcel.2006.10.010>
22. Pohlodek K, Tan YY, Singer CF, Gschwantler-Kaulich D 2016: Cadherin-11 expression is upregulated in invasive human breast cancer. Oncol Lett 12: 4393-4398 <https://doi.org/10.3892/ol.2016.5236>
23. Putnová B, Putnová I, Škorič M, Buchtová M 2021: The expression of selected Wnt pathway members (FZD6, AXIN2 and β-Catenin) in canine oral squamous cell carcinoma and acanthomatous ameloblastoma. Animals 11: 1615 <https://doi.org/10.3390/ani11061615>
24. Reis AL, Carvalheira J, Schmitt FC, Gärtner F 2003: Immunohistochemical study of the expression of E-cadherin in canine mammary tumours. Vet Rec 152: 621-624 <https://doi.org/10.1136/vr.152.20.621>
25. Restucci B, Papparella S, De Vico G, Maiolino P 1997: E cadherin expression in normal and neoplastic canine mammary gland. J Comp Pathol 116: 191-202 <https://doi.org/10.1016/S0021-9975(97)80076-X>
26. Rezaie A, Tavasoli A, Bahonar A, Mehrazma M 2009: Grading in canine mammary gland carcinoma. Biol Sci 9: 333-338 <https://doi.org/10.3923/jbs.2009.333.338>
27. Salas Y, Márquez A, Diaz D, Romero L, Seagroves T 2015: Epidemiological study of mammary tumors in female dogs diagnosed during the period 2002-2012: A growing animal health problem. PLOS ONE 10.
28. Sleeckx N, De Rooster H, Veldhuis Kroeze, EJB, Van Ginneken C, Van Brantegem L 2011: Canine mammary tumours, an overview. Repro Domest Anim 46: 1112-1131 <https://doi.org/10.1111/j.1439-0531.2011.01816.x>
29. Soler A, Knudsen KA, Salazar H, Han AC, Keshgegian AA 1999: P-cadherin expression in breast carcinoma indicates poor survival. Cancer 86: 1263-1272 <https://doi.org/10.1002/(SICI)1097-0142(19991001)86:7<1263::AID-CNCR23>3.0.CO;2-2>
30. Sorenmo KU, Rasotto RV, Zappulli V, Goldschmidt MH 2011: Development, anatomy, histology, lymphatic drainage, clinical features, and cell differentiation markers of canine mammary gland neoplasms. Vet Pathol 48: 85-97 <https://doi.org/10.1177/0300985810389480>
31. Takeichi M 1993: Cadherins in cancer: implications for invasion and metastasis. Curr Opin Cell Biol 5: 806-811 <https://doi.org/10.1016/0955-0674(93)90029-P>
32. Wong AST, Gumbiner BM 2003: Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin. J Cell Biol 161: 1191-1203 <https://doi.org/10.1083/jcb.200212033>
33. Yokoya F, Imamoto N, Tachibana T, Yoneda Y 1999: beta-catenin can be transported into the nucleus in a Ran-unassisted manner. Mol Biol Cell 10:1119-1131 <https://doi.org/10.1091/mbc.10.4.1119>
34. Yoshida R, Kimura N, Harada Y, Ohuchi N 2001: The loss of E-cadherin, alpha- and beta-catenin expression is associated with metastasis and poor prognosis in invasive breast cancer. Int J Oncol 18: 513-520
35. Yu F, Rasotto R, Zhang H, Pei S, Zhou B, Yang X, Jin Y, Zhang D, Lin D 2017: Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT2 Profiler PCR Array and immunochemistry assays. J Vet Sci 18: 359-367 <https://doi.org/10.4142/jvs.2017.18.3.359>
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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