Acta Vet. Brno 2024, 93: 93-103

Nontyping virulence factors of Clostridium perfringens

Irena Svobodová, Radka Hulánková

University of Veterinary Sciences Brno, Faculty od Veterinary Hygiene and Ecology, Department of Animal Origin Food and Gastronomic Sciences, Brno, Czech Republic

Received May 31, 2023
Accepted February 19, 2024

The anaerobic, rod-shaped, spore-forming bacterium Clostridium perfringens is known for its production of biochemically active substances. Most of them are proteins that have a pathogenic effect on a wide range of animal tissues and cause a specific syndrome or even a disease in humans or animals. Production of toxins is used to classify isolates of C. perfringens into 7 different toxin types (A–G). Other virulence factors (i.g. beta2-toxin, BEC toxin, sialidases, hyaluronidase etc.) only indirectly or partially participate in the development of the disease, and the function of some substances has not been fully elucidated. The article summarizes basic data on the non-typing virulence factors of C. perfringens.


This work was supported by the project of the Ministry of Agriculture of the Czech Republic QK22010086 (Multiplex detection and identification of genes responsible for antimicrobial resistence and toxin production in important bacterial agent in foodstuffs).


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