Acta Vet. Brno 2024, 93: 183-199
https://doi.org/10.2754/avb202493020183
The protective role of virgin olive oil and vitamin E on mercury-induced hepatic, renal, testicular and adrenal toxicity in the rabbit (Oryctolagus cuniculus)
References
1. DH, Sonne C, Basu N, Dietz R, Nam DH, Leifsson PS, Jensen AL 2010: Mercury contamination in spotted seatrout, Cynoscion nebulosus: An assessment of liver, kidney, blood, and nervous system health. Sci Total Environ 408: 5808-5816
<https://doi.org/10.1016/j.scitotenv.2010.08.019>
2. R, Sudhir KG, Ramesh C, Jai Raj B 2010: Role of vitamin E in preventing acute mercury toxicity in rat. Environ Toxicol Pharmacol 29: 70-78
<https://doi.org/10.1016/j.etap.2009.10.003>
3. Z, Choudhary S, Naeem M, Masroor M, Khan A, Aftab T 2019 : A review of medicinal and aromatic plants and their secondary metabolites status under abiotic stress. J Med Plants Stud 7: 99-106
4. M, Prenzler PD, Patsalides E, McDonald S, Robards K 2002: Methods for testing antioxidant activity. Analyst 127: 183-198
<https://doi.org/10.1039/b009171p>
5. FG, Baş H, Kalender S, Kalender Y 2016: Subacute effects of low dose lead nitrate and mercury chloride exposure on kidney of rats. Environ Toxicol Pharmacol 41: 219-224
<https://doi.org/10.1016/j.etap.2015.12.003>
6. M, Sato Y, Arai H, Inoue K 1998: Binding of a tocopherylquinone, an oxidized form of α-tocopherol, to glutathione-s-transferase in the liver cytosol. FEBS Lett 436: 424-426
<https://doi.org/10.1016/S0014-5793(98)01176-4>
7. H, Abdel-Rahman M, Khodair A 1993: The mechanism of methyl mercury toxicity in isolated rat hepatocytes. Toxicol Lett 69: 87-96
<https://doi.org/10.1016/0378-4274(93)90149-R>
8. S, Natsume M, Yasuda A, Nakamura Y, Tamura T, Osakabe N, Kanegae M, Kondo K 2007: Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder. J Nutr 137: 1436-1441
<https://doi.org/10.1093/jn/137.6.1436>
9. Y, Hasan M 1990: Histopathological lesions in the body organs of catfish, Heteropneustes fossilis following mercury intoxication. J Environ Sci Health 25: 67-85
<https://doi.org/10.1080/03601239009372677>
10. G 2003: Generation of reactive oxygen species in biological systems. Comments Toxicol 9: 5-21
<https://doi.org/10.1080/08865140302420>
11. DMG, Schep LJ, Slaughter RJ, Temple WA, Michel JM 2014: Full recovery from a potentially lethal dose of mercuric chloride. J Med Toxicol 10: 40-44
<https://doi.org/10.1007/s13181-013-0311-1>
12. D, Christophe A, Delanghe J, Langlois M, De Buyzere M, Comhaire F 2003: The effect of supplementation with an antioxidant preparation on LDL-oxidation is determined by haptoglobin polymorphism. Redox Rep 8: 41-46
<https://doi.org/10.1179/135100003125001233>
13. RA 2012: Mercury toxicity and treatment: a review of the literature. Int J Environ Res Public Health 2012: 460508
14. LM, Samal SA, Halmy MW, Heneidy SZ 2015: Goods and services provided by native plants in desert ecosystems: examples from the northwestern coastal desert of Egypt. Glob Ecol Conserv 3: 433-447
15. MA, Hamden K, Guermazi F, Bouslama A, Omezzine A, Kammou A, El Feki A 2009: Testicular toxicity in mercuric chloride treated rats: association with oxidative stress. Reprod Toxicol 28: 81-89
<https://doi.org/10.1016/j.reprotox.2009.03.011>
16. JC, Sherwood G, Rasmussen JB, Hontela A 1997: lmpaired cortisol secretion in yellow perch (Perca jlavescens) from lakes contaminated by heavy metals: In vivo and in vitro assessment. Can J Fish Aquat Sci 54: 2752-2758
<https://doi.org/10.1139/f97-200>
17. S, OleszekW 2001: Antioxidant and antiradical activities of flavonoids. J Agric Food Chem 49: 2774-2779
<https://doi.org/10.1021/jf001413m>
18. GV, Meikle AW 1980: Acute and chronic methyl mercury poisoning impairs rat adrenal and testicular function. J Toxicol Environ Health 6: 597-606
<https://doi.org/10.1080/15287398009529877>
19. V, Onaindia M, Alday JG, Caballero D, Carrasco JC, McLaren B, Amigo J 2016: Plant diversity and ecosystem services in Amazonian homegardens of Ecuador. Agric Ecosyst Environ 225: 116-125
<https://doi.org/10.1016/j.agee.2016.04.005>
20. L, Gomez-Baggethun E, Reyes-García V 2012: Beyond food production: ecosystem services provided by home gardens. A case study in Vall Fosca, Catalan Pyrenees, northeastern Spain. Ecol Econ 74: 153-160
<https://doi.org/10.1016/j.ecolecon.2011.12.011>
21. S, Ray A, Mukherjee S, Agarwal S, Kundu R, Bhattacharya S 2012: Low concentration of mercury induces autophagic cell death in rat hepatocytes. Toxicol Ind Health 30: 211-620
22. L, Roy V, Jeljeli M, Sakly M 2012: Chronic exposure to mercuric chloride during gestation affects sensorimotor development and later behaviour in rats. Behav Brain Res 234: 43-50
<https://doi.org/10.1016/j.bbr.2012.06.005>
23. J, Sokołowska-Mikołajczyk M, Kime DE, Socha M, Epler P 2001: The influence of mercury on computer analyzed sperm motility of common carp, Cyprinus carpio L., in vitro. Arch Pol Fis 9: 51-60
24. HY, Fırat O, Fırat O, Yüzereroǧlu TA, Gök G, Kargin F, Kötemen Y 2012: Protective effect of selenium against mercury-induced toxicity on hematological and biochemical parameters of Oreochromis niloticus. J Biochem Mol Toxicol 26: 117-122
<https://doi.org/10.1002/jbt.20417>
25. CT, Harrison MD 1998: Mechanisms for protection against copper toxicity. Am J Clin Nutr 67: 1091-1097
<https://doi.org/10.1093/ajcn/67.5.1091S>
26. BJ, Price HC, O’Connor RW, Fernando R, Rowland AS, Morgan DL 2001: Mercury vapor and female reproductive toxicity. Toxicol Sci 59: 291-296
<https://doi.org/10.1093/toxsci/59.2.291>
27. V, Souza HP, Rossoni LV, França AS, Vassallo DV 2000: Effects of mercury on the isolated perfused rat tail vascular bed are endothelium-dependent. Arch Environ Contam Toxicol 39: 124-130
<https://doi.org/10.1007/s002440010001>
28. P, Gomes-Ferrari R, Neves dos Santos L, Conte Junior CA 2019 : Mercury in aquatic fauna contamination: A systematic review on its dynamics and potential health risks. J Environ Sci 84: 205-218
<https://doi.org/10.1016/j.jes.2019.02.018>
29. AC, Regitano-d’Arce MAB, Biasoto ACT, Shahidi F 2014: Low molecular weight phenolics of grape juice and winemaking byproducts: antioxidant activities and inhibition of oxidation of human low-density lipoprotein cholesterol and DNA strand breakage. J Agric Food Chem 62: 12159-12171
<https://doi.org/10.1021/jf504185s>
30. G, Officioso A, D’Angelo S, La Cara F, Ionata E, Marcolongo L, Squillaci G, Maurelli L, Morana A 2015: Characterization of extra virgin olive oils produced with typical Italian varieties by their phenolic profile. Food Chem 184: 220-228
<https://doi.org/10.1016/j.foodchem.2015.03.071>
31. D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A 2013: Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18: 1818-1892
<https://doi.org/10.1089/ars.2012.4581>
32. C, Lazarini JG, Franchin M, et al. 2014: Bioprospection of petit verdot grape pomace as a source of anti-inflammatory compounds. J Funct Foods 8: 292-300
<https://doi.org/10.1016/j.jff.2014.03.016>
33. Devlin TM 1997: Textbook of biochemistry with clinical correlations. Wiley, New York. Fourth Edition. 1186 p.
34. F, Valentino A, Petillo O, Peluso G, Filosa S, Crispi S 2020: Bioactive polyphenols and neuromodulation: molecular mechanisms in neurodegeneration. Int J Mol Sci 21: 2564
<https://doi.org/10.3390/ijms21072564>
35. CL 2008: Biomarkers of acute kidney injury. Adv Chronic Kidney Dis 15: 222-234
<https://doi.org/10.1053/j.ackd.2008.04.003>
36. El Boustani E, Prost J, Benkhalti F, El Yodafar C, Stocker P, Jimenez F, Prerez 2004 : Régime alimentaire méditerranéen et protection contre les maladies cardiovasculaires. Congrés international de Biochimie-Forum des jeunes Chercheurs, Marrakech, Maroc
37. FM 2001: Effects of selenium and mercury on the enzymatic activities and lipid peroxidation in brain, liver and blood of rats. J Environ Sci Health B 36: 489-499
<https://doi.org/10.1081/PFC-100104191>
38. SMA, Hassan NS 2008: Comparative evaluation of the protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats. Pharmacol Rep 60: 199-208
39. WJ 2000: Vitamin E, vitamin C, and exercise. Am J Clin Nutr 72: 647S-652S
<https://doi.org/10.1093/ajcn/72.2.647S>
40. AM, Oliveira CS, Franciscato C, Oliveira VA, Pereira JS, Bertoncheli CM, Da Luz SC, Dressler VL, Flores EM, Pereira ME 2014: Lactating and nonlactating rats differ to renal toxicity induced by mercuric chloride: the preventive effect of zinc chloride. Cell Biochem Funct 32: 420-428
<https://doi.org/10.1002/cbf.3032>
41. P, Prencipe L 1982: Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 28: 2077-2080
<https://doi.org/10.1093/clinchem/28.10.2077>
42. P, Principe L, Berti G 1980: Use of 3.5-dichloro-2-hydroxybenzene sulfonic acid / 4 amino phenazone chromogenic system in direct enzymatic assays of uric acid in serum and urine. Clin Chem 26: 227-231
<https://doi.org/10.1093/clinchem/26.2.227>
43. DA, Teixera CT, Scarano WR, Favareto AP, Frenandez CD, Grotto D, Barbosa F, Kempinas WG 2011: Effects of methylmercury on male reproductive function in wistar rats. Reprod Toxicol 31: 431-439
<https://doi.org/10.1016/j.reprotox.2011.01.002>
44. C, Moraes-Silva L, Duarte FA, Oliveira CS, Ineu RP, Flores EM, Dressler VL, Peixoto NC, Pereira ME 2011: Delayed biochemical changes induced by mercury intoxication are prevented by zinc pre-exposure. Ecotoxical Environ Saf 74: 480-486
<https://doi.org/10.1016/j.ecoenv.2010.11.011>
45. L, Mottet NK 1989: Accumulation of methylmercury and inorganic mercury in the brain. Biol Trace Elem Res 21: 201-206
<https://doi.org/10.1007/BF02917253>
46. AM, Aldahmash BA 2013: Antioxidant effect of Arabic gum against mercuric chloride-induced nephrotoxicity. Drug Des Devel Ther 7: 1245-1255
<https://doi.org/10.2147/DDDT.S50928>
47. MB, Catalá A 2006: The effect of α-tocopherol on lipid peroxidation of microsomes and mitochondria from rat testis. Prostaglandins Leukot Essent Fatty Acids 74: 247-254
<https://doi.org/10.1016/j.plefa.2006.01.007>
48. H, O’Leary KG 2014: Mercury exposure and health impacts among individuals in the artisanal and small-scale gold mining community: a comprehensive review. Environ Health Perspect 122: 667-672
<https://doi.org/10.1289/ehp.1307864>
49. C 2001: Vitamines et anti-cholestérol ne font pas bon ménage. Arterioscler Thromb Vasc Biol 21: 1320-1326
50. PK, Sastry KV 1981: Effect of mercuric chloride on enzyme activities in the digestive system and chemical composition of liver and muscles of the catfish, Heteropneustes fossilis. Ecotoxicol Environ Saf 5: 389-400
<https://doi.org/10.1016/0147-6513(81)90013-0>
51. G, Fogazzi GB, Cantu M, Minoia, Ronchi A, Pigatto PD, Severi G 2008: Dental amalgam, mercury toxicity and renal autoimmunity glomerular disease. J Environ Pathol Toxicol Oncol 27: 147-155
<https://doi.org/10.1615/JEnvironPatholToxicolOncol.v27.i2.70>
52. S, Chargui I, Najjar MF, Sriha B, Abdelhamid El Hani A 2013: Liver function and structure in rats treated simultaneously with cadmium and mercury. Open J Pathol 3: 1-6
<https://doi.org/10.4236/ojpathology.2013.31005>
53. H, Seghir BB, Zeghoud S, Ben Amor I, Kouadri I, Rebiai A, Zaater A, Messaoudi M, Benchikha N, Sawicka B, Atanassova M 2023: Desert endemic plants in Algeria: a review on traditional uses, phytochemistry, polyphenolic compounds and pharmacological activities. Molecules 28: 1834
<https://doi.org/10.3390/molecules28041834>
54. Henry S 2003: Olive oil, its nutritional value, and uses in pharmacy and cosmetics. Thesis presented to obtain the diploma of state of doctor of pharmacy, Henri Poincaré University, Faculty of Pharmacy - Nancy 1, France
55. JA, Sanchez ER 2022: The role of the hypothalamus-pituitary-adrenal (HPA) axis in test-induced anxiety: assessments, physiological responses, and molecular details. Stresses 2: 146-155
<https://doi.org/10.3390/stresses2010011>
56. S, Kugenuma Y, Iwamura T, Kumagai Y, Shimojo N 2001: Impairment of spermatogegesis in rats by methylmercury: involvement of stage- and cell-specific germ cell apoptosis. Toxicology 169: 25-35
<https://doi.org/10.1016/S0300-483X(01)00487-5>
57. A 1997: Endocrine and physiological responses of fish to xenobiotics: role of glucocorticosteroid hormones. Environ Toxicol Rev 1: 1-46
58. A, Rasmussen JB, Audet C, Chevalier G 1992: Impaired cortisol stress response in fish from environments polluted by PAHs, PCBs, and mercury. Arch Environ Contam Toxicol 22: 278-283
<https://doi.org/10.1007/BF00212086>
59. AK, Khaled MA, Mahran, AR, Mahmoud AK 2012: Bioremediation the toxic effect of mercury on liver histopathology, some hematological parameters and enzymatic activity in Nile tilapia, Oreochromis niloticus. Res 4: 60-69
60. L, Siroki O, Undeger U, Basaran N, Banerjee BD, Desi I 2001: Detection of the effects of repeated dose combined propoxur and heavy metal exposure by measurement of certain toxicological, hematological and immune function parameters in rats. Toxicol 163: 185-193
<https://doi.org/10.1016/S0300-483X(01)00381-X>
61. SH, Sarkar SN, Patil RD, Tripathi HC 2007: Effects of subchronic exposure via drinking water to a mixture of eight water-contaminating metals: a biochemical and histopathological study in male rats. Arch Environ Contam Toxicol 53: 667-677
<https://doi.org/10.1007/s00244-007-0031-0>
62. C, Carpena MC, Gallardo-Gomez M, Lorenzo JL, Barba FJ, Prieto MA, Gandara JS 2020: Bioactive compounds and quality of extra virgin olive oil. Foods 9: 10-14
<https://doi.org/10.3390/foods9081014>
63. L, María del CC, Francisco M 2019: Nanoplastics in the environment and the effects on the zebrafish. Am J Eng Appl Sci 12: 472-475
64. S, Uzun FG, Demir F, Uzunhisarcıklı M, Aslanturk A 2013: Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E. Food Chem Toxicol 55: 456-462
<https://doi.org/10.1016/j.fct.2013.01.024>
65. KS 1973: Reproductive capability of male rats and mice treated with methyl mercury. Toxicol Appl Pharmacol 24: 167-177
<https://doi.org/10.1016/0041-008X(73)90136-1>
66. R, Joy KP 1988: Inhibition of testicular 3β-hydroxy-Δ5 –steroid dehydrogenase (3β-HSD) activity in catfish Clarias batrachus L. by mercurials. Indian J Exp Biol 26: 907-908
67. R, Joy KP 1991: Changes in adrenocortical-pituitary activity in the catfish Clarias batrachus (L), after mercury treatment. Ecotoxicol Environ Saf 22: 63-44
<https://doi.org/10.1016/0147-6513(91)90045-Q>
68. Z, Lukac N, Forgacs Z, Tvrda E, Lukacova J, Slivkova J, Binkowski L, Massanyi P 2013: Effects of mercury on the steroidgenesis of human adrenocarcinoma (NCI-H295R) cell line. J Environ Sci Health, Part A 48: 348-353
<https://doi.org/10.1080/10934529.2013.726908>
69. SAR, Wickliffe J, Shankar A, Shafer M, Hindori-Mohangoo AD, Covert HH, Lichtveld M, Zijlmans W 2022: The association between mercury and lead exposure and liver and kidney function in pregnant Surinamese women enrolled in the Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) environmental epidemiologic cohort study. Toxics 10: 584
<https://doi.org/10.3390/toxics10100584>
70. Lapointe G 2004: Notions de toxicologie. Commission de la santé et de la sécurité du travail du Québec, Second Edition, 67 p.
71. YA, Steiner JM 2017: Laboratory evaluation of the liver. Vet Clin Small Anim 47: 539-553
<https://doi.org/10.1016/j.cvsm.2016.11.005>
72. IP, Dixon RL 1975: Effects of mercury on spermatogenesis studied by velocity sedimentation cell separation and serial mating. J Pharmacol Exp Ther 194:171-181
73. M, Van Gossum A, Kurian R, Ostro M, Axler J, Jeejeebhoyet KN 1987: Breath pentane analysis as an index of lipid peroxidation: a functional test of vitamin E status. Am J Clin Nutr 46: 267-272
<https://doi.org/10.1093/ajcn/46.2.267>
74. Liu J, Goyer RA, Waalkes MP 2008: Toxic effects of metals. In: Casarett LJ, Doull J, Klaassen CD (Eds): Toxicology: the basic science of poisons. McGraw-Hill, New York, pp. 931-979
75. Liz H 2003: Monitoring tests for people with HIV–liver function tests. Bull Exp Treat AIDS. Available at: http://www.aegis.com/pubs/beta/2003/be030703.html. Accessed September 17, 2009
76. IJ, Kotsanis N 2001: Toxic effects of cadmium and mercury in rainbow trouth (Oncorhynchus mykiss): a short-term bioassay. Bull Environ Contam Toxicol 66: 77-85
77. V, Patil A, Phatak A, Chandra N 2010: Free radicals, antioxidants, and functional foods: Impact on human health. Pharmacogn Rev 4: 118-126
<https://doi.org/10.4103/0973-7847.70902>
78. WL, Uthe JF, Kenney AR, Mehrle PM 2011: Methylmercury in northern pike (Esox lucius): Distribution, elimination, and some biochemical characteristics of contaminated fish. J Fish Res Board Can 29: 1519-1523
<https://doi.org/10.1139/f72-240>
79. S, Rowland I, Spencer JC, Yaqoob, Stonehousse W 2016: Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers. A randomized controlled trial. Eur J Nutr 56: 1421-1432
<https://doi.org/10.1007/s00394-016-1188-y>
80. J, Zheng Y, Tang W, Yan W, Nie H, Fang J, Liu G 2020 : Dietary polyphenols in lipid metabolism: A role of gut microbiome. Anim Nutr 6: 404-409
<https://doi.org/10.1016/j.aninu.2020.08.002>
81. L 1987: The effect of mercury on the cattle organism. Acta Vet Brno 56: 73-78
<https://doi.org/10.2754/avb198756010073>
82. Martoja R, Martoja M 1967: Initiation aux techniques de l’histologie animale. Ed Masson et Cie, Paris. 349 p.
83. P, Lukac N, Slivkova J, Kovacik J, Makarevich AV, Chrenek P, Toman R, Forgacs Z, Somosy Z, Stawarz R, Formicki G 2007: Mercury-induced alterations in rat kidneys and testes in vivo. J Environ Sci Health A Tox Hazard Subst Environ Eng 42: 865-870
<https://doi.org/10.1080/10934520701370410>
84. MJ, Cooke GM, Curran IH, Chan HM, Kubow S, Lok E, Mehta R 2008: An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels. Food Chem Toxicol 46: 270-279
<https://doi.org/10.1016/j.fct.2007.08.004>
85. ZAA, Ahmed NEM, Hamad MNM, El hossin YS, Alamin N, Osman A 2021: The influence of mercury on renal function test among mining gold workers in river Nile state, Sudan. Saudi J Biomed Res 6: 58-62
<https://doi.org/10.36348/sjbr.2021.v06i04.002>
86. L, Bueno TM, Franciscato C, Oliveira CS, Peixoto NC, Pereira ME 2012: Mercury chloride increases hepatic alanine aminotransferase and glucose 6- phosphatase activities in newborn rats in vivo. Cell Biol Int 36: 561-566
<https://doi.org/10.1042/CBI20100475>
87. Y, Abdennour C 2008: Influence of vitamin C on testicular functions of domestic rabbit Oryctolagus cuniculus under mercury exposure. Eur J Sci Res 22: 197-204
88. Y, Abdennour C, Loudjani F 2011: Influence of plan date and vitamin C supplementation on testicular function of domestic rabbit Oryctolagus cuniculus under mercury exposure. Ann Biol Res 2: 359-369
89. D 2009: Fish, mercury, selenium and cardio-vascular risk: current evidence and unanswered question. Int J Environ Res Public Healt 6: 1894-1916
<https://doi.org/10.3390/ijerph6061894>
90. Murray RL, Kaplan A, Peace AL 1984a: Alanine aminotransferase. In: Kaplan LA, Pesce AJ (EDs): Clinical Chemistry: Theory, Analysis, Correlation. The C.V. Mosby Co.; St. Louis, MO, USA. pp. 1088-1090
91. Murray RL, Kaplan A, Peace AL 1984b: Aspartate aminotransferase. In: Kaplan LA, Pesce AJ (EDs): Clinical Chemistry: Theory, Analysis, Correlation. The C.V. Mosby Co.; St. Louis, MO, USA. pp. 1112-1116
92. Murray RL, Kaplan A, Peace AL 1984c: Creatinine. In: Kaplan LA, Pesce AJ (EDs): Clinical Chemistry: Theory, Analysis, Correlation. The C.V. Mosby Co.; St. Louis, MO, USA. Pp. 1261-1266
93. Naito HK 1984: Cholesterol. In: Kaplan LA, Pesce AJ (EDs): Clinical Chemistry: Theory, Analysis, Correlation. The C.V. Mosby Co.; St. Louis, MO, USA. pp. 1194-1206
94. Y, Bahi A, Zerizer S, Abdennour C, Boulakoud MS 2013: Effect of virgin olive oil (Olea europea, L) on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Am J Biochem Biotechnol 9: 415-422
<https://doi.org/10.3844/ajbbsp.2013.415.422>
95. E 2021: Lipid oxidation that is, and is not, inhibited by vitamin E: consideration about physiological functions of vitamin E. Free Radic Biol Med 176: 1-15
<https://doi.org/10.1016/j.freeradbiomed.2021.09.001>
96. VA, Oliveira CS, Ineu RP, Moraes-Silva L, Siqueira LF, Pereira ME 2014 : Lactating and non-lactating rats differ in sensitivity to HgCl2: protective effect of ZnCl2. J Trace Elem Med Biol 28: 240-246
<https://doi.org/10.1016/j.jtemb.2014.01.005>
97. S, Saidullah B, Ravi K, Fahim M 2013: Vasorelaxant effects of mercury on rat thoracic aorta: the nitric oxide signaling mechanism. Hum Exp Toxicol 33: 904-910
<https://doi.org/10.1177/0960327113512341>
98. FQ, Hirschfield GM 2020: The pathophysiology of cholestasis and its relevance to clinical practice. Clin Liver Dis 15: 110-114
<https://doi.org/10.1002/cld.894>
99. OE, Afonne OJ, Nwobodo E, Asomugha L, Dioka CE 2001: Low-dose mercury induces testicular damage protected by zinc in mice. Eur J Obstet Gynecol Reprod Biol 95: 92-96
<https://doi.org/10.1016/S0301-2115(00)00374-2>
100. MS, Safwat G, Aboulkhair M, Abdel Moneim AE 2014: The potential effect of berberine in mercury-induced hepatorenal toxicity in albino rats. Food Chem Toxicol 69: 175-181
<https://doi.org/10.1016/j.fct.2014.04.012>
101. R, Giacosa A, Hull W, Haubner R, Spiegelhalder B, Bartsch H 2000: The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 36: 1235-1247
<https://doi.org/10.1016/S0959-8049(00)00103-9>
102. L, Tritschler HJ, Wessel K 1997: Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med 22: 359-378
<https://doi.org/10.1016/S0891-5849(96)00269-9>
103. JM 2020: Recent advances in mercury research. Sci Total Environ 738: 139955
<https://doi.org/10.1016/j.scitotenv.2020.139955>
104. JD, Zheng W 2012: Human exposure and health effects of inorganic and elemental mercury. J Prev Med Public Health 45: 344-352
<https://doi.org/10.3961/jpmph.2012.45.6.344>
105. NC, Pereira ME 2007: Effectiveness of ZnCl2 in protecting against nephrotoxicity induced by HgCl2 in newborn rats. Ecotoxicol Environ Saf 66: 441-446
<https://doi.org/10.1016/j.ecoenv.2006.02.012>
106. NC, Rocha LC, Moraes DP, Bebianno MJ, Dressler VL, Flores EMM, Pereira ME 2008: Changes in levels of essential elements in suckling rats exposed to zinc and mercury. Chemosphere 72: 1327-1332
<https://doi.org/10.1016/j.chemosphere.2008.04.027>
107. S, Pocino M, Marval MJ, Loreta J, Gallardo L, Vila J 2009: Modification in rat testicular morphology and increases in IFN-gamma serum levels by the oral administration of subtoxic doses of mercuric chloride. Syst Biol Reprood Med 55: 69-84
<https://doi.org/10.1080/19396360802562678>
108. FIT, Petrescu RVV 2020: Aspects related to the human body plant. Ind J Manag Prod 11: 15-38
<https://doi.org/10.14807/ijmp.v11i1.944>
109. I, Wehe CA, Bornhorst J, Ebert F, Leffers L, Holtkamp M, Hoseler P, Weber T, Mangerich A, Burkle A, Karst U, Schwerdtle T 2014: Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response. Metallomics 6: 662-671
<https://doi.org/10.1039/C3MT00337J>
110. V, Vimaladevi V, Rajeswary S, Suryavathi V 2003: Effect of mercuric chloride on circulating hormones in adult albino rats. J Environ Biol 24: 401-414
111. SVS 2014: Prospectives in endocrine toxicity of heavy metals – a review. Biol Trace Elem Res 160: 1-14
<https://doi.org/10.1007/s12011-014-0023-7>
112. SVS, Rekha S, Seema V 1996: Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury. Ind J Exp Biol 34: 177-179
113. MV, Sharma PS 2001: Protective effects of vitamin E against mercuric chloride reproductive toxicity in male mice. Reprod Toxicol 15: 705-712
<https://doi.org/10.1016/S0890-6238(01)00183-6>
114. IS, Bando I, Andres D, Cascales M 2003: Relationship between expression of HSP 70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats. J Biochem Mol Toxicol 17:161-168
<https://doi.org/10.1002/jbt.10074>
115. KM, Ernest M, Walker EM Jr, Wu M, Gillette C, Blough ER 2014: Environmental mercury and its toxic effects. J Prev Med Public Health 47: 74-83
<https://doi.org/10.3961/jpmph.2014.47.2.74>
116. CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB 1995: The relative antioxidant activities of plant-derived polyphenolic flavonoids. Free Radic Res 22: 375-383
<https://doi.org/10.3109/10715769509145649>
117. JS, Hocker JR, Hanas RJ, Nwosu EC, Hanas JS 2001: Mercuric ion inhibition of eukaryotic transcription factor binding to DNA. Biochem Pharmacol 61: 1543-1550
<https://doi.org/10.1016/S0006-2952(01)00629-3>
118. TH, An KG, Kim JK 2014: Genotoxicity in earthworm after combined treatment of ionising radiation and mercury. Radiat Prot Dosimetry 159: 111-117
<https://doi.org/10.1093/rpd/ncu172>
119. A, Farokhi F, Shalizar-Jalali A, Najafi G 2020: Protective effect of vitamin E on sperm quality and in vitro fertilizing potential and testosterone concentration in polyvinyl chloride treated male rats. Vet Res Forum 11: 257-263
120. H, Hara K, Kitajima S, Tanemura K 2020: Effect of vitamin E deficiency on spermatogenesis in mice and its similarity to aging. Reprod Toxicol 98: 225-232
<https://doi.org/10.1016/j.reprotox.2020.10.003>
121. JT 2006: The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals. Review Toxicol Sci 94: 3-21
<https://doi.org/10.1093/toxsci/kfl051>
122. K, Ali S, Hameed S, Afzal S, Fatima S, Shakoor MB, Bharwana SA, Tauqeer HM 2013: Heavy metals contamination and what are the impacts on living organisms. Greener J Environ Manage Public Saf 2: 172-179
123. H, Straub E, Funke PJ 1977: Influence of L-thyroxine upon enzymatic activity in the renal tubular epithelium of the rat under normal conditions and in mercury-induced lesions. Virchows Archiv B 23: 163-173
124. L, Strasser B, Hoffmann G 2011: Effects of monounsaturated fatty acids on cardiovascular risk factors: A systematic review and meta-analysis. Ann Nutr Metab 59: 176-186
<https://doi.org/10.1159/000334071>
125. RL, Reardon JE, Foreman JA 1967: A new photometric method for serum urea nitrogen determination. Am J Med Technol 33: 15-20
126. J, Banudevi S, Sharmila M, Murugesan P, Srinivasan N, Balasubramanian K, Aruldhas MM, Arunakaran J 2004: Effects of vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells. Reprod Biol Endocrinol 19: 201-208
127. MG 2022: Amelioration of mercuric chloride-induced physiologic and histopathologic alterations in rats using vitamin and zinc chloride supplement. Heliyon 8: e12036
<https://doi.org/10.1016/j.heliyon.2022.e12036>
128. MK, Kumar M, Kumar A 2002: Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol 40: 1079-1082
129. MK, Patni R, Kumar M, Kumar A 2005: Modification of mercury-induced biochemical alterations in blood of Swiss albino mice by Spirulina fusiformis. Environ Toxicol Pharmacol 20: 289-296
<https://doi.org/10.1016/j.etap.2005.02.006>
130. A, Hussain S, Khan R, Mumtaz S, Ashraf N, Andleeb S, Shakir HA, Tahir HM, Khan MKA, Ulhaq M 2019: Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits. Environ Sci Pollut Res 26: 3909-3920
131. V, Gupta V, Sharma K, Bhatnagar S, Kumari R, Dhaka N 2013: Potential applications of antioxidants-a review. J Pharm Res 7: 828-835
132. W, Abdennour C 2015: Can Urtica dioica supplementation attenuate mercury intoxication in wistar rats? Vet World 8: 1458-1465
<https://doi.org/10.14202/vetworld.2015.1458-1465>
133. F, Macchi C, Abbate R, Gensini GF, Casini A 2013: Mediterranean diet and health. BioFactors 39: 335-342
<https://doi.org/10.1002/biof.1096>
134. GS, Anderson JL, Gutewmann WH, Bache GA, Lish DJ 1971: Eggshell thinning in Japanese quail fed mercuric chloride. Science 173: 1030-1031
<https://doi.org/10.1126/science.173.4001.1030>
135. A, Ganetzky R, Daniel J, Rader DJ 2021: Hepatic manifestations of Mendelian disorders of cholesterol biosynthesis and cellular metabolism. Clin Liver Dis 18: 266-273
<https://doi.org/10.1002/cld.1154>
136. N, Lai YR, Sugawara C, Arizono K 1998: Decreased hepatobiliary secretion of inorganic mercury, its deposition and toxicity in the Eisai hyperbilirubinemic rat with no hepatic canalicular organic anion transporter. Toxicol 126: 23-31
<https://doi.org/10.1016/S0300-483X(97)00170-4>
137. SI, Xiang Y, Oli MW, Foley DP, Huang G, Hayes RL, Ottens AK, Wang KKW 2006: Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Biomarkers 11: 355-369
<https://doi.org/10.1080/13547500600775110>
138. B, Krmer SD 2009: The biochemistry of drug metabolism – an introduction part 5: metabolism and bioactivity. Chem Biodivers 6: 591-684
<https://doi.org/10.1002/cbdv.200900022>
139. JP, Parkhurst CP 1973: Abnormal mating behavior and reproductive dysfunction caused by mercury in Japanese quail. Proc Soc Exp Biol Med 144: 252-255
<https://doi.org/10.3181/00379727-144-37567>
140. MS, Hazelhoff MH, Chevalier AA, Passamonti S, Brandoni AM, Torres AM 2014: Protein expression of kidney and liver bilitranslocase in rats exposed to mercuric chloride–a potential tissular biomarker of toxicity. Toxicol Lett 225: 305-310
<https://doi.org/10.1016/j.toxlet.2013.11.022>
141. V 2018: Natural phytotherapeutic antioxidants in the treatment of mercury intoxication-a review. Pharm Bull 8: 365-376
<https://doi.org/10.15171/apb.2018.043>
142. M, Aslanturk A, Kalender S, Apaydin FG, Bas H 2016: Mercuric chloride induced hepatotoxic and hematologic changes in rats: The protective effects of sodium selenite and vitamin E. Toxicol Ind Health 32: 1651-1662
<https://doi.org/10.1177/0748233715572561>
143. KD, Chowdhury AR 1990: Distribution of mercury and evaluation of testicular steroidogenesis in mercuric chloride and methylmercury administered rats. Indian J Exp Biol 28: 746-751
144. A, Fiotakis K, Vlachogianni T 2008: Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26: 339-362
<https://doi.org/10.1080/10590500802494538>
145. A, Kurian R, Whitwell J, Ieejeebhoy KN 1988: Decrease in lipid peroxidation measured by breath pentane output in normals after oral supplementation with vitamin E. Clin Nutr 7: 53-57
<https://doi.org/10.1016/0261-5614(88)90012-X>
146. M, Girish KS, Kumar MK 2004: Isolation and characterization of cytosolic alanine aminotransferase isoforms from starved rat liver. Mol Cell Biochem 267: 13-23
<https://doi.org/10.1023/B:MCBI.0000049354.55955.12>
147. KB, Radhakrishnan CK, Chacko J 1997: Heavy metal induced biochemical effects in an estuarine teleost. Indian J Mar Sci 26: 74-78
148. JC, Maines MD 1986: Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal. Arch Biochem Biophys 248: 467-478
<https://doi.org/10.1016/0003-9861(86)90500-X>
149. AI, Pshak VP, Lopushins’ka IV 2014: Activity of antioxidant enzymes of the rat kidneys under mercury dichloride effect. Ukr Biokhim Zh 86: 124-130
150. S, Singh SP 2008: Current and future status of herbal medicines. Vet World 1: 347-350
<https://doi.org/10.5455/vetworld.2008.347-350>
151. HC, Rodrigues ACM, Soares AMVM, Abreu S, Morgado F 2021: Mercury accumulation and elimination in different tissues of zebrafish (Danio rerio) exposed to a mercury-supplemented diet. J Mar Sci Eng 9: 882
<https://doi.org/10.3390/jmse9080882>
152. H, Cristol DA, McNabb FM, Hopkins WA 2009: Suppressed adrenocortical responses and thyroid hormone levels in birds near a mercury contaminated river. Environ Sci Technol 43: 6031-6038
<https://doi.org/10.1021/es803707f>
153. MAM 2009: Effect of mercury exposure on blood chemistry and liver histopathology of male rats. J Pharmacol Toxicol 4: 126-131
<https://doi.org/10.3923/jpt.2009.126.131>
154. Bonga SE 1997: The stress response in fish. Physiol Rev 77: 591-625
<https://doi.org/10.1152/physrev.1997.77.3.591>
155. Wenger C, Kaplan A, Rubaltelli FF, Hammerman C 1984: Alkaline phosphatase. Clin Chem 1094-1098
156. RK, Bridges CC 2010: Seventy-five percent nephrectomy and the disposition of inorganic mercury in 2,3-dimercaptopropanesulfonic acid-treated rats lacking functional multidrug-resistance protein 2. J Pharmacol Exp Ther 332: 866-875
<https://doi.org/10.1124/jpet.109.163774>
157. X, Kusaka Y, Sato K, Zhang Q 2000: The endocrine disruptive effects of mercury. Environ Health Prev Med 4: 174-183
<https://doi.org/10.1007/BF02931255>
158. BR, Papadopoulos V 2018: Leydig cells: formation, function, and regulation. Biol Reprod 99:101-111
<https://doi.org/10.1093/biolre/ioy059>
