Acta Vet. Brno 2024, 93: 145-157

https://doi.org/10.2754/avb202493020145

Comparison of two different doses of xylazine and ketamine versus medetomidine for partial intravenous anaesthesia in horses

Natália Rovňanová1, Andrea Paprnáková1, Vladimír Petrovič2, Alexandra Valicová3, Zdeněk Žert1

1University of Veterinary Medicine and Pharmacy in Košice, Equine Clinic, Košice, Slovakia
2The University of Veterinary Medicine and Pharmacy in Košice, Department of Pharmacology and Toxicology, Košice, Slovakia
3University of Žilina, Department of Communications, Žilina, Slovakia

Received January 18, 2023
Accepted June 18, 2024

References

1. Algera MH, Kamp J, van der Schrier R, van Velzen M, Niesters M, Aarts L, Dahan A, Olofsen E 2019: Opioid-induced respiratory depression in humans: a review of pharmacokinetic–pharmacodynamic modelling of reversal. Br J Anaesth 122: e168-e179 <https://doi.org/10.1016/j.bja.2018.12.023>
2. Bennett RC, Steffey EP, Kollias-Baker C, Sams R 2004: Influence of morphine sulfate on the halothane sparing effect of xylazine hydrochloride in horses. Am J Vet Res 65: 519-526 <https://doi.org/10.2460/ajvr.2004.65.519>
3. Bettschart-Wolfensberger R, Larenza MP 2007: Balanced anesthesia in the equine. Clin Tech Equine Pract 6: 104-110 <https://doi.org/10.1053/j.ctep.2007.05.002>
4. Bettschart-Wolfensberger R, Freeman SL, Bowen IM, Aliabadi FS, Weller R, Huhtinen M, Clarke KW 2005: Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies. Equine Vet J 37: 60-64 <https://doi.org/10.2746/0425164054406801>
5. Bettschart-Wolfensberger R, Jäggin-Schmucker N, Lendl C, Bettschart RW, Clarke KW 2001: Minimal alveolar concentration of desflurane in combination with an infusion of medetomidine for the anaesthesia of ponies. Vet Rec 148: 264-267 <https://doi.org/10.1136/vr.148.9.264>
6. Bettschart-Wolfensberger R, Johnston M 2012: Confidential enquiry into perioperative equine fatalities: CEPEF 4-a chance to gain new evidence about the risks of equine general anaesthesia. Equine Vet J 44: 7 <https://doi.org/10.1111/j.2042-3306.2011.00483.x>
7. Bettschart-Wolfensberger R, Taylor PM, Sear JW, Bloomfield MR, Rentsch K, Dawling S 1996: Physiologic effects of anesthesia induced and maintained by intravenous administration of a climazolam-ketamine combination in ponies premedicated with acepromazine and xylazine. Am J Vet Res 57: 1472-1477 <https://doi.org/10.2460/ajvr.1996.57.10.1472>
8. Bryant CE, England GCW, Clarke KW 1991: A comparison of the sedative effects of medetomidine and xylazine in the horse. Vet Anaesth Analg 18: 55-57
9. Celly CS, McDonell WN, Young SS, Black WD 1997: The comparative hypoxaemic effect of four alpha 2 adrenoceptor agonists (xylazine, romifidine, detomidine and medetomidine) in sheep. J Vet Pharmacol Ther 20: 464-471 <https://doi.org/10.1046/j.1365-2885.1997.00097.x>
10. Diaz FA, Bianco JA, Bello A, Beer N, Velarde H, Izquierdo JP, Jaen R 1976: Effects of ketamine on canine cardiovascular function. Br J Anaesth 48: 941-946 <https://doi.org/10.1093/bja/48.10.941>
11. Doherty T, Valverde A 2006: Manual of Equine Anesthesia and Analgesia. Blackwell Publishing, Ames, IA, USA, 379 p.
12. Eikermann M, Grosse-Sundrup M, Zaremba S, Henry ME, Bittner EA, Hoffmann U, Chamberlin NL 2012: Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction. Anesthesiology 116: 35-46 <https://doi.org/10.1097/ALN.0b013e31823d010a>
13. Enderle AK, Levionnois OL, Kuhn M, Schatzmann U 2008: Clinical evaluation of ketamine and lidocaine intravenous infusions to reduce isoflurane requirements in horses under general anaesthesia. Vet Anaesth Analg 35: 297-305 <https://doi.org/10.1111/j.1467-2995.2007.00391.x>
14. Fielding CL, Brumbaugh GW, Matthews NS, Peck KE, Roussel AJ 2006: Pharmacokinetics and clinical effects of a subanesthetic continuous rate infusion of ketamine in awake horses. Am J Vet Res 67: 1484-1490 <https://doi.org/10.2460/ajvr.67.9.1484>
15. Flaherty D, Nolan A, Reid J, Flaherty D, Nolan A, Monteiro AM 1998: The pharmacokinetics of ketamine after a continuous infusion under halothane anesthesia in horses. J Vet Anaesth 25: 31-36 <https://doi.org/10.1111/j.1467-2995.1998.tb00166.x>
16. Gozalo-Marcilla M, Steblaj B, Schauvliege S, Duchateau L, Gasthuys F 2013: Comparison of the influence of two different constant-rate infusions (dexmedetomidine versus morphine) on anaesthetic requirements, cardiopulmonary function and recovery quality in isoflurane anaesthetized horses. Res Vet Sci 95: 1186-1194 <https://doi.org/10.1016/j.rvsc.2013.09.014>
17. Hall LW, Clarke KW, Trim CM 2000: Anaesthesia of the horse. In: Hall LW, Clarke KW (Eds): Veterinary Anaesthesia. Philadelphia, PA, Saunders, pp 247-313
18. Hubbell J, Muir W 2009: Monitoring anesthesia. In: Muir W, Hubbell J (Eds): Equine Anesthesia Monitoring and Emergency Therapy. 2nd edn. St. Louis, MO, Saunders Elsevier, pp 149-170
19. Hubbell JA, Saville WJ, Bednarski RM 2010: The use of sedatives, analgesic and anaesthetic drugs in the horse: an electronic survey of members of the American Association of Equine Practitioners. Equine Vet J 42: 487-493 <https://doi.org/10.1111/j.2042-3306.2010.00104.x>
20. Kälin I, Henze IS, Ringer SK, Torgerson PR, Bettschart-Wolfensberger R 2021: Comparison of recovery quality following medetomidine versus xylazine balanced isoflurane anaesthesia in horses: a retrospective analysis. Animals (Basel) 11: 2440 <https://doi.org/10.3390/ani11082440>
21. Kempchen S, Kuhn M, Spadavecchia C, Levionnois OL 2012: Medetomidine continuous rate intravenous infusion in horses in which surgical anaesthesia is maintained with isoflurane and intravenous infusions of lidocaine and ketamine. Vet Anaesth Analg 39: 245-255 <https://doi.org/10.1111/j.1467-2995.2011.00701.x>
22. Kerr C, McDonell W 2009: Oxygen supplementation and ventilator support. In: Muir W, Hubbell J (Eds): Equine Anesthesia Monitoring & Emergency Therapy. 2nd edn. St. Louis, MO, Saunders Elsevier, pp 332-353
23. Knobloch M, Portier CJ, Levionnois OL, Theurillat R, Thormann W, Spadavecchia C, Mevissen M 2006: Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion. Toxicol Appl Pharmacol 216: 373-386 <https://doi.org/10.1016/j.taap.2006.06.011>
24. Lankveld DP, Driessen B, Soma LR, Moate PJ, Rudy J, Uboh CE, van Dijk P, Hellebrekers LJ 2006: Pharmacodynamic effects and pharmacokinetic profile of a long-term continuous rate infusion of racemic ketamine in healthy conscious horses. J Vet Pharmacol Ther 29: 477-488 <https://doi.org/10.1111/j.1365-2885.2006.00794.x>
25. Larenza MP, Peterbauer C, Landoni MF, Levionnois OL, Schatzmann U, Spadavecchia C, Thormann W 2009: Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies. Am J Vet Res 70: 831-839 <https://doi.org/10.2460/ajvr.70.7.831>
26. Larenza MP, Ringer SK, Kutter AP, Conrot A, Theurillat R, Kummer M, Thormann W, Bettschart-Wolfensberger R 2009: Evaluation of anesthesia recovery quality after low-dose racemic or S-ketamine infusions during anesthesia with isoflurane in horses. Am J Vet Res 70: 710-718 <https://doi.org/10.2460/ajvr.70.6.710>
27. Laurenza C, Ansart L, Portier K 2020: Risk factors of anesthesia-related mortality and morbidity in one equine hospital: a retrospective study on 1,161 cases undergoing elective or emergency surgeries. Front Vet Sci 6: 514 <https://doi.org/10.3389/fvets.2019.00514>
28. Luna SP, Taylor PM, Wheeler MJ 1996: Cardiovascular, endocrine and metabolic changes in ponies undergoing intravenous or inhalation anesthesia. J Vet Pharmacol Ther 19: 251-258 <https://doi.org/10.1111/j.1365-2885.1996.tb00046.x>
29. Mama KR, Wagner AE, Steffey EP, Kollias-Baker C, Hellyer PW, Golden AE, Brevard LF 2005: Evaluation of xylazine and ketamine for total intravenous anesthesia in horses. Am J Vet Res 66: 1002-1007 <https://doi.org/10.2460/ajvr.2005.66.1002>
30. McMurphy RM, Young LE, Marlin DJ, Walsh K 2002: Comparison of the cardiopulmonary effects of anesthesia maintained by continuous infusion of romifidine, guaifenesin, and ketamine with anesthesia maintained by inhalation of halothane in horses. Am J Vet Res 63: 1655-1661 <https://doi.org/10.2460/ajvr.2002.63.1655>
31. McNally E, Pablo L 2009: Equine anesthesia. In: Reeder D, Miller S, Wilfong D, Leitch M, Zimmel D (Eds): AAEVT’s Equine Manual for Veterinary Technicians. Wiley-Blackwell Publishing Ames, IA, USA, pp 217-249
32. Muir WW 3rd, Sams R 1992: Effects of ketamine infusion on halothane minimal alveolar concentration in horses. Am J Vet Res 53: 1802-1806 <https://doi.org/10.2460/ajvr.1992.53.10.1802>
33. Neges K, Bettschart-Wolfensberger R, Müller J, Fürst A, Kästner S 2003: The isoflurane sparing effect of a medetomidine constant rate infusion in horses. Vet Anaesth Analg 30: 92 <https://doi.org/10.1046/j.1467-2995.2003.00132_8.x>
34. Rowland S 2013: Blood Pressure Management in Equine Anesthesia. Veterinary Technician E1-E6
35. Sacks M, Ringer SK, Bischofberger AS, Berchtold SM, Bettschart-Wolfensberger R 2017: Clinical comparison of dexmedetomidine and medetomidine for isoflurane balanced anaesthesia in horses. Vet Anaesth Analg 44: 1128-1138 <https://doi.org/10.1016/j.vaa.2016.12.061>
36. Schatzmann U, Girard P 1984: Anesthesia in the horse. Tierarztl Prax 12: 323-328
37. Schauvliege S, Marcilla MG, Verryken K, Duchateau L, Devisscher L, Gasthuys F 2011: Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses. Vet Anaesth Analg 38: 544-554 <https://doi.org/10.1111/j.1467-2995.2011.00659.x>
38. Schwartz DA, Horwitz LD 1975: Effects of ketamine on left ventricular performance. J Pharmacol Exp Ther 194: 410-414
39. Solano AM, Valverde A, Desrochers A, Nykamp S, Boure LP 2009: Behavioural and cardiorespiratory effects of a constant rate infusion of medetomidine and morphine for sedation during standing laparoscopy in horses. Equine Vet J 41: 153-159 <https://doi.org/10.2746/042516408X342984>
40. Spadavecchia C, Stucki F, Moens Y, Schatzmann U 2002: Anaesthesia in horses using halothane and intravenous ketamine-guaiphenesin: a clinical study. Vet Anaesth Analg 29: 20-28 <https://doi.org/10.1046/j.1467-2987.2001.00060.x>
41. Steffey EP, Pascoe PJ, Woliner MJ, Berryman ER 2000: Effects of xylazine hydrochloride during isoflurane-induced anesthesia in horses. Am J Vet Res 61: 1225-1231 <https://doi.org/10.2460/ajvr.2000.61.1225>
42. Treese N, Niemczyk H, Reuther P 1973: Animal experiments on the effect of ketamine on the cardiovascular system as produced by the myocardium and central nervous system. Der Anaesthesist 22: 117-120
43. Valverde A 2010: Alpha-2 agonists for pain therapy in horses. Vet Clin North Am Equine Pract 26: 515-532 <https://doi.org/10.1016/j.cveq.2010.07.003>
44. Valverde A 2012: Balanced anesthesia and constant-rate infusions in horses. Vet Clin North Am Equine Pract 29: 89-122 <https://doi.org/10.1016/j.cveq.2012.11.004>
45. Valverde A, Rickey E, Sinclair M, Rioja E, Pedernera J, Hathway A, Cruz A 2010: Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery. Equine Vet J 42: 192-199 <https://doi.org/10.1111/j.2042-3306.2010.00027.x>
46. Villalba M, Santiago I, Gomez de Segura IA 2011: Effects of constant rate infusion of lidocaine and ketamine, with or without morphine, on isoflurane MAC in horses. Equine Vet J 43: 721-726 <https://doi.org/10.1111/j.2042-3306.2010.00355.x>
47. Wiederkehr A, Barbarossa A, Ringer SK, Jörger FB, Bryner M, Bettschart-Wolfensberger R 2021: Clinical randomized comparison of medetomidine and xylazine for isoflurane balanced anesthesia in horses. Front Vet Sci 8: 603695 <https://doi.org/10.3389/fvets.2021.603695>
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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