Acta Vet. Brno 2024, 93: 397-404

https://doi.org/10.2754/avb202493040397

The occurrence of preclinical dilated cardiomyopathy in the Weimaraner dog breed and the prognostic importance of cardiac markers

Zita Filipejová1, Lucie Metelková2, Benicie Kosková1, Andrea Nečasová3, Lucie Urbanová3, Petr Linhart4, Shubhadeep Roychoudhury5, Michal Fiedler6, Alois Nečas3

1University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Department of Medicine, Czech Republic
2Hradec Králové Veterinary Clinic, Hradec Králové, Czech Republic
3University of Veterinary Sciences Brno, Faculty of Veterinary Medicine, Small Animal Clinic, Department of Surgery & Orthopaedics, Czech Republic
4University of Veterinary Sciences Brno, Faculty of Veterinary Hygiene and Ecology, Department of Animal Protection and Welfare and Veterinary Public Health, Czech Republic
5Assam University, Department Life Science & Bioinformatics, Faculty of Reproductive Biology, Human & Environmental Health, Silchar, India
6Slaný Veterinary Clinic, Slaný, Czech Republic

Received June 26, 2024
Accepted December 12, 2024

References

1. Arbustini E, Pucci A, Grasso M, Diegoli M, Pozzi R, Gavazzi A, Graziano G, Campana C, Goggi C, Martinelli L, Silini E, Specchia G, Vigano M, Solcia E 1990: Expression of natriuretic peptide in ventricular myocardium of failing human hearts and its correlation with the severity of clinical and hemodynamic impairment. Am J Cardiol 66: 973-980 <https://doi.org/10.1016/0002-9149(90)90936-U>
2. Baumwart RD, Orvalho J, Meurs KM 2007: Evaluation of serum cardiac troponin I concentration in Boxers with arrhythmogenic right ventricular cardiomyopathy. Am J Vet Res 68: 524-528 <https://doi.org/10.2460/ajvr.68.5.524>
3. DeFrancesco TC, Rush JE, Rozanski EA, Hansen BD, Keene BW, Moore DT, Atkins CE 2007: Prospective clinical evaluation of an ELISA B‐type natriuretic peptide assay in the diagnosis of congestive heart failure in dogs presenting with cough or dyspnea. J Vet Intern Med 21: 243-250
4. Dukes-McEwan J, Borgarelli M, Tidholm A, Vollmarr AC, Häggström J; ESVC Taskforce for canine dilated cardiomyopathy 2003: Proposed guidelines for diagnosis of canine idiopathic dilated cardiomyopathy. J Vet Cardiology 5: 7-19 <https://doi.org/10.1016/S1760-2734(06)70047-9>
5. Eisenman A 2006: Troponin assays for the diagnosis of myocardial infarction and acute coronary syndrome: Where do we stand? Expert Rev Cardiovasc Ther 4: 509-514 <https://doi.org/10.1586/14779072.4.4.509>
6. Goetze JP, Rehfeld JF, Videbaek R, Friis‐Hansen L, Kastrup J 2005: B‐type natriuretic peptide and its precursor in cardiac venous blood from failing hearts. Eur J Heart Fail 7: 69-74 <https://doi.org/10.1016/j.ejheart.2004.04.012>
7. Gordon SG, Estrada AH, Braz‐Ruivo L 2016: Evaluation of NTproBNP, high sensitivity troponin I and PDK4 for the detection of occult DCM: a prospective study in 449 Doberman Pinschers. (Oral Abstract ECVIM Forum 2015). J Vet Intern Med 30: 365
8. Hunt SA, Baker DW, Chin MH, Cinquegrani MP, Feldman AM, Francis GS, Ganiats TG, Goldstein S, Gregoratos G, Jessup ML, Noble RJ, Packer M, Silver MA, Stevenson LW, Gibbons RJ, Antman EM, Alpert JS, Faxon DP, Fuster V, Gregoratos G, Jacobs AK, Hiratzka LF, Russell RO, Smith SC, American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure), International Society for Heart and Lung Transplantation, Heart Failure Society of America, 2001: ACC/AHA Guidelines for the Evaluation and Management of Chronic Heart Failure in the Adult: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the International Society for Heart and Lung Transplantation; Endorsed by the Heart Failure Society of America. Circulation 104: 2996-3007
9. Jishi F, Hudson PR, Williams CP, Jones RP, Davies GK, Yousef ZR, Trent RJ, Cowell RPW 2004: Troponin I, laboratory issues, and clinical outcomes in a district general hospital: crossover study with “traditional” markers of myocardial infarction in a total of 1990 patients. J Clin Pathol 57: 1027-1032 <https://doi.org/10.1136/jcp.2003.011551>
10. Keene BW, Atkins CE, Bonagura JD, Fox PR, Häggström J, Fuentes VL, Oyama MA, Rush JE, Stepien R, Uechi M 2019: ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs. J Vet Intern Med 33: 1127-1140 <https://doi.org/10.1111/jvim.15488>
11. Klüser L, Maier ET, Wess G 2019: Evaluation of a high-sensitivity cardiac troponin I assay compared to a first-generation cardiac troponin I assay in Doberman Pinschers with and without dilated cardiomyopathy. J Vet Intern Med 33: 54-63 <https://doi.org/10.1111/jvim.15384>
12. Langhorn R, Willesen Jl 2016: Cardiac troponins in dogs and cats. J Vet Intern Med 30: 36-50 <https://doi.org/10.1111/jvim.13801>
13. LaVecchio D, Marin LM, Baumwart R, Iazbik MC, Westendorf N, Couto CG 2009: Serum cardiac troponin I concentration in retired racing greyhounds. J Vet Intern Med 23: 87-90 <https://doi.org/10.1111/j.1939-1676.2008.0237.x>
14. Luchner A, Stevens TL, Borgeson DD, Redfield M, Wei CM, Porter JG, Burnett JC 1998: Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure. Am J Physiol 274: H1684-H1689
15. Luis Fuentes V, Abbott J, Chetboul V, Côté E, Fox PR, Häggström J, Kittleson MD, Schober K, Stern JA 2020: ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats. J Vet Intern Med 34: 1062-1077 <https://doi.org/10.1111/jvim.15745>
16. Oyama MA, Boswood A, Connolly DJ, Ettinger SJ, Fox PR, Gordon SG, Rush JE, Sisson DD, Stepien RL, Wess G, Zannad F 2013: Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease. J Am Vet Med Assoc 243: 71-82 <https://doi.org/10.2460/javma.243.1.71>
17. Oyama MA, Fox PR, Rush JE, Rozanski EA, Lesser M 2008: Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. J Am Vet Assoc 232: 1496-1503 <https://doi.org/10.2460/javma.232.10.1496>
18. Oyama MA, Sisson DD 2004: Cardiac troponin‐I concentration in dogs with cardiac disease. J Vet Intern Med 18: 831-839
19. Pérez JM, Alessi C, Grzech-Wojciechowska M 2020: Diagnostic methods for the canine idiopathic dilated cardiomyopathy: A narrative evidence-based rapid review. Res Vet Sci 128: 205-216 <https://doi.org/10.1016/j.rvsc.2019.12.001>
20. Shaw SP, Rozanski EA, Rush JE 2004: Cardiac troponins I and T in dogs with pericardial effusion. J Vet Intern Med 18: 322-324 <https://doi.org/10.1111/j.1939-1676.2004.tb02552.x>
21. Singletary GE, Morris NA, Lynne O’Sullivan M, Gordon SG, Oyama MA 2012: Prospective evaluation of NT-proBNP assay to detect occult dilated cardiomyopathy and predict survival in Doberman Pinschers. J Vet Intern Med 26: 1330-1336 <https://doi.org/10.1111/j.1939-1676.2012.1000.x>
22. Spratt DP, Mellanby RJ, Drury N, Archer J 2005: Cardiac troponin I: evaluation of a biomarker for the diagnosis of heart disease in the dog. J Small Anim Pract 46: 139-145 <https://doi.org/10.1111/j.1748-5827.2005.tb00304.x>
23. Taggart DP, Hadjinikolas L, Wong K, Yap J, Hooper J, Kemp M, Hue D, Yacoub M, Lincoln JC 1996: Vulnerability of paediatric myocardium to cardiac surgery. Heart 76: 214-217 <https://doi.org/10.1136/hrt.76.3.214>
24. Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC 1993: Natriuretic peptide system in human heart failure. Circulation 88: 1004-1009 <https://doi.org/10.1161/01.CIR.88.3.1004>
25. Wess G 2022: Screening for dilated cardiomyopathy in dogs. J Vet Cardiol 40: 51-68 <https://doi.org/10.1016/j.jvc.2021.09.004>
26. Wess G, Butz V, Mahling M, Hartmann K 2011: Evaluation of N-terminal pro-B-type natriuretic peptide as a diagnostic marker of various stages of cardiomyopathy in Doberman Pinschers. Am J Vet Res 72: 642-649 <https://doi.org/10.2460/ajvr.72.5.642>
27. Wess G, Domenech O, Dukes-McEwan J, Häggström J, Gordon S 2017: European Society of Veterinary Cardiology screening guidelines for dilated cardiomyopathy in Doberman Pinschers. J Vet Cardiol 19: 405-415 <https://doi.org/10.1016/j.jvc.2017.08.006>
28. Wess G, Mäurer J, Simak J, Hartmann K 2010a: Use of Simpson’s method of disc to detect early echocardiographic changes in Doberman Pinschers with dilated cardiomyopathy. J Vet Intern Med 24: 1069-1076 <https://doi.org/10.1111/j.1939-1676.2010.0575.x>
29. Wess G, Simak J, Mahling M, Hartmann K 2010b: Cardiac troponin I in Doberman Pinschers with cardiomyopathy. J Vet Intern Med 24: 843-849 <https://doi.org/10.1111/j.1939-1676.2010.0516.x>
30. Yasue H, Obata K, Okumura K, Kurose M, Ogawa H, Matsuyama K, Jougasaki M, Saito Y, Nakao K, Imura H 1989: Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy. J Clin Invest 83: 46-51 <https://doi.org/10.1172/JCI113883>
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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