Acta Vet. Brno 2025, 94: 173-180

https://doi.org/10.2754/avb202594030173

Effect of iron/anticoccidial treatment via injection on growth performance in piglets under the field conditions of a standard commercial Danish pig herd

Line Hummelmose Diness1, Michael Albin Larsen1, Poul Skovsby Toft2, Rikke Skovsgaard Nielsen2, Nils Toft3, Charlotte Sonne Kristensen1, Daniel Šperling4

1CEVA Animal Health, Vejle, Denmark
2PORCUS Aps, Odense, Denmark
3Toft Analytics ApS, Værløse, Jonstrup, Denmark
4CEVA Santé Animale, Libourne, France

Received July 2, 2025
Accepted August 13, 2025

References

1. Bach U, Kalthoff V, Mundt H-C, Popp A, Rinke M, Daugschies A, Luttge B 2003: Parasitological and morphological findings in porcine isosporosis after treatment with symmetrical triazintriones. Parasitol Res 91: 27-33 <https://doi.org/10.1007/s00436-003-0828-3>
2. Bates D, Mächler M, Bolker B, Walker S 2015: Fitting Linear Mixed-Effects Models Using lme4. J Stat Softw 67: 1-48 <https://doi.org/10.18637/jss.v067.i01>
3. Core Team 2023 R. R: A language and environment for statistical computing; R Foundation for Statistical Computing, Vienna, Austria. Clinical Report
4. Deak G, González-Amador L, Goyena E. Cârstolovean AS, Risueńo J, Berriatua E 2024: On the efficacy of preventive toltrazuril treatments and the diagnosis of Cystoisospora suis infections in intensively raised piglets in farms from southeast Spain. Parasitol Res 123: 109 <https://doi.org/10.1007/s00436-024-08127-y>
5. EMA (European Medicines Agency) 2019: Summary of opinion: initial authorisation Forceris International non-proprietary name: toltrazuril / gleptoferron; EMA/CVMP/64773
6. Hinney B, Cvjetković V, Espigares D, Vanhara J, Waehner C, Ruttkowski B, Selista R, Sperling D, Joachim A 2020: Cystoisospora suis control in Europe is not always effective. Front Vet Sci 7: 113 <https://doi.org/10.3389/fvets.2020.00113>
7. Hiob L, Holzhausen I, Sperling D, Pagny G, Meppiel L, Isaka N, Daugschies A. 2019: Efficacy of an injectable toltrazuril - gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treatment. Vet Parasitol 1: 100002 <https://doi.org/10.1016/j.vpoa.2019.100002>
8. Joachim A, Ruttkowski B, Sperling D 2018: Detection of Cystoisospora suis in faeces of suckling piglets – when and how? A comparison of methods. Porcine Health Manag 4: 20 <https://doi.org/10.1186/s40813-018-0097-2>
9. Joachim A, Guerra N, Hinney B, Hodžić A, Karembe H, Shrestha A, Sperling D 2019: Efficacy of injectable toltrazuril-iron combination product and oral toltrazuril against early experimental infection of suckling piglets with Cystoisospora suis. Parasit Vectors 12: 272 <https://doi.org/10.1186/s13071-019-3527-3>
10. Karembe H, Sperling D, Varinot N, Magnier R, Peyrou M, Guerra N, Smola J, Vasek J, Hinney B, Joachim A 2021: Absorption and distribution of toltrazuril and toltrazuril sulfone in plasma, intestinal tissues and content of piglets after oral or intramuscular administration. Molecules 26: 5633 <https://doi.org/10.3390/molecules26185633>
11. Karembe H, Geneteau A, Lacoste S, Varinot N, Magnier R, Coussanes E, Lopez S, Sperling D, Peyrou 2024: Comparison of an injectable toltrazuril–gleptoferron and an oral toltrazuril + injectable gleptoferron in piglets: Hematinic activities and pharmacokinetics. J Vet Pharmacol Therapy 47: 492-502 <https://doi.org/10.1111/jvp.13464>
12. Kreiner T, Worliczek HL, Tichy A, Joachim A 2011: Influence of toltrazuril treatment on parasitological parameters and health performance of piglets in the field – An Austrian experience. Vet Parasitol 183: 14-20 <https://doi.org/10.1016/j.vetpar.2011.07.019>
13. Lindsay DS, Current WL, Taylor JR 1985: Effects of experimentally induced Isospora suis infection on morbidity, mortality, and weight gains in nursing pigs. Am J Vet Res 46: 1511-1512 <https://doi.org/10.2460/ajvr.1985.46.07.1511>
14. Maes D, Vyt P, Rabaeys P, Gevaert D 2007: Effects of toltrazuril on the growth of piglets in herds without clinical isosporosis. Vet J Jan 173: 197-199 <https://doi.org/10.1016/j.tvjl.2005.07.002>
15. Mengel H, Kruger M, Kruger MU, Westphal B, Swidsinski A, Schwarz S, Mundt HC, Dittmar K, Daugschies A 2011: Necrotic enteritis due to simultaneous infection with Isospora suis and clostridia in newborn piglets and its prevention by early treatment with toltrazuril. Parasitol Res 110: 1347-1355 <https://doi.org/10.1007/s00436-011-2633-8>
16. Mundt HC, Mundt-Wüstenberg S, Daugschies A, Joachim A 2006: Efficacy of various anticoccidials against experimental porcine neonatal isosporosis. Parasitol Res 100: 401-411 <https://doi.org/10.1007/s00436-006-0314-9>
17. Rypula K, Porowski M, Kaba J, Gorczykowski M, Deniz A 2012: effect of isosporosis prevention with toltrazuril on long-term pig performance. Sci World 2012: 486324
18. Scala A, Demontis F, Varcasia A, Pipia AP, Poglayen G, Ferrari N, Genchi M 2009: Toltrazuril and sulphonamide treatment against naturally Isospora suis infected suckling piglets: Is there an actual profit? Vet Parasitol 163: 362-365 <https://doi.org/10.1016/j.vetpar.2009.04.028>
19. Sperling D, Calveyra J, Karembe H, de Freitas Costa E. 2022: Cystoisospora suis infection in suckling piglets in Brazil: Prevalence and associated factors. Vet Parasitol Reg Stud Reports 36: 100796
20. Sperling D, Murciano F, Gonzalez-Guijarro, Hernández-Rodríguez EV, Serrano D, Llamas E, Ramis G 2023: Differences in tight junctions gene expression after toltrazuril parenteral administration. In: Proceeding of ESPHM conference, Thessaloniki, Greece. IMM-PP-21, p. 212
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  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

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