Acta Vet. Brno 2026, 95: 149-155

https://doi.org/10.2754/avb202695020149

A new Mycobacterium bovis spoligotype in a domestic cat – case study

Deniz Zeynep Telci1, Orhan Kaya Köksalan2, Hazal Öztürk Gürgen3, Ahmet Gülçubuk3, Kemal Metiner4, Belgi Diren Sığırcı4, Mehmet Erman Or1, Banu Dokuzeylül1, Lora Koenhemsi1

1Istanbul University-Cerrahpaşa, Faculty of Veterinary Medicine, Department of Internal Medicine, Avcılar, Istanbul, Türkiye
2Istanbul University, Faculty of Medicine, Department of Medical Microbiology, Fatih, Istanbul, Türkiye
3Istanbul University-Cerrahpaşa, Faculty of Veterinary Medicine, Department of Pathology, Büyükçekmece, Istanbul, Türkiye
4Istanbul University-Cerrahpaşa, Faculty of Veterinary Medicine, Department of Microbiology, Büyükçekmece, Istanbul, Türkiye

Received December 10, 2025
Accepted May 4, 2026

References

1. Alves AS, Araujo SB, Ferreira JS, Medeiros LKG, Oliveira EL, Dantas AFM, Souza AP 2019: Aspectos clínicos e terapęuticos de infecçăo por Mycobacterium bovis em gato doméstico – relato de caso (Clinical and therapeutic aspects of Mycobacterium bovis infection in a domestic cat – case report). Arq Bras Med Vet Zootec 71: 1896-1900 <https://doi.org/10.1590/1678-4162-10247>
2. Aydın FE, Ulger M, Emekdaş G, Aslan G, Günal S 2012: Isolation and identification of Mycobacterium bovis and non-tuberculous mycobacteria in raw milk samples in Mersin province. Mikrobiyoloji Bülteni 46: 283-289
3. Cerna P, O’Halloran C, Sjatkovskaj O, Gunn-Moore DA 2019: The outbreak of tuberculosis caused by Mycobacterium bovis in a cattery of Abyssinian cats in Italy. Transbound Emerg Dis 66: 250-258 <https://doi.org/10.1111/tbed.13010>
4. Çavuşoğlu C, Yılmaz FF 2017: Molecular epidemiology of human Mycobacterium bovis infection in Aegean Region, Turkey. Mikrobiyoloji Bülteni 51: 165-170 <https://doi.org/10.5578/mb.53963>
5. Didkowska A, Zmuda P, Orlowska B, Anusz K 2024: Mycobacterial infections in cats (Felis catus) as a potential threat to humans – a review 2014–2023. Med Weter 80: 53-57
6. Eroksuz Y, Baydar E, Otlu B, Dabak M, Eroksuz H, Karabulut B, Timurkan MO 2019: Systemic tuberculosis caused by Mycobacterium bovis in a cat. BMC Vet Res 15: 1-4 <https://doi.org/10.1186/s12917-018-1759-7>
7. Gokalp G, Gulbahar MY, Pekmezci D, Gacar A, Soylu SM, Cakiroglu D, Meral Y 2011: A feline tuberculosis case. Kafkas Univ Vet Fak Derg 17: 155-157
8. Gunn-Moore DA 2014: Feline mycobacterial infections. Vet J 201: 230-238 <https://doi.org/10.1016/j.tvjl.2014.02.014>
9. Gunn-Moore DA, McFarland SE, Brewer JI, Crawshaw TR, Clifton-Hadley RS, Kovalik M, Shaw DJ 2011: Mycobacterial disease in cats in Great Britain: I. Culture results, geographical distribution and clinical presentation of 339 cases. J Feline Med Surg 13: 934-944 <https://doi.org/10.1016/j.jfms.2011.07.012>
10. Güven Gökmen T, Yakici G, Kalayci Y, Turut N, Meral Öcal M, Haligür M, Günaydin E, Köksal F 2022: Molecular characterization of Mycobacterium bovis strains isolated from cattle and humans by spoligotyping and 24-locus MIRU-VNTR, and prevalence of positive IGRA in slaughterhouse workers in Southern Turkey. Iran J Vet Res 23: 210-218
11. Haligur M, Vural SA, Sahal M, Ural K, Berkin S 2007: Generalised tuberculosis in a cat. Bull Vet Inst Pulawy 51: 531
12. Kamerbeek J, Schouls L, Kolk A, van Agterveld M, van Soolingen D, Kuijper S, Bunschoten A, Molhuizen H, Shaw R, Goyal M, van Embden J 1997: Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol 35: 907-914 <https://doi.org/10.1128/jcm.35.4.907-914.1997>
13. Malik R, Wigney DI, Dawson D, Martin P, Hunt GB, Love DN 2000: Infection of the subcutis and skin of cats with rapidly growing mycobacteria: a review of microbiological and clinical findings. J Feline Med Surg 2: 35-48 <https://doi.org/10.1053/jfms.2000.0051>
14. Maxie G (Ed.) 2016: Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 6th edn. Elsevier, St. Louis, 737 p.
15. Mitchell JL, Gunn-Moore DA 2019: Mycobacterial infections in cats and dogs. Vet Nurs J 34: 102-107 <https://doi.org/10.1080/17415349.2018.1551103>
16. Mitchell JL, MacDougall L, Dobromylskyj MJ, Smith K, Stavinohova R, Gunn-Moore DA, Scurrell E 2022: Ocular mycobacterial lesions in cats. Vet Pathol 59: 792-805 <https://doi.org/10.1177/03009858221098431>
17. Murray A, Dineen A, Kelly P, McGoey K, Madigan G, NiGhallchoir E, Gunn-Moore DA 2015: Nosocomial spread of Mycobacterium bovis in domestic cats. J Feline Med Surg 17: 173-180 <https://doi.org/10.1177/1098612X14529768>
18. O’Connor CM, Nunez-Garcia J, de la Rua-Domenech R, Smith NH, Roberts T 2019: Cat-to-human transmission of Mycobacterium bovis, United Kingdom. Emerg Infect Dis 25: 2284-2286 <https://doi.org/10.3201/eid2512.190012>
19. O’Halloran C, Ioannidi O, Reed N, Murtagh K, Dettemering E, Van Poucke S, Gunn-Moore DA 2019: Tuberculosis due to Mycobacterium bovis in pet cats associated with feeding a commercial raw food diet. J Feline Med Surg 21: 667-681 <https://doi.org/10.1177/1098612X19848455>
20. Pesciaroli M, Alvarez J, Boniotti MB, Cagiola M, Di Marco V, Marianelli C, Pacciarini M, Pasquali P 2014: Tuberculosis in domestic animal species. Res Vet Sci 97: S78-S85 <https://doi.org/10.1016/j.rvsc.2014.05.015>
21. Ramdas KEF, Lyashchenko KP, Greenwald R, Robbe-Austerman S, McManis C, Waters WR 2015: Mycobacterium bovis infection in humans and cats in the same household, Texas, USA, 2012. Emerg Infect Dis 21: 480-483 <https://doi.org/10.3201/eid2103.140715>
22. Roberts T, O’Connor C, Nunez-Garcia J, de la Rua-Domenech R, Smith NH 2014: Unusual cluster of Mycobacterium bovis infection in cats. Vet Rec 174: 326 <https://doi.org/10.1136/vr.102457>
23. Şahin F, Tarhan GL, Cinoğlu H, Kayar MBM, Yakıcı GL 2022: Spoligotyping and polymerase chain reaction based Mycobacterium bovis strains typing with methods (enterobacterial repetitive intergenic consensus-polymerase chain reaction, randomly amplified polymorphic DNAs-polymerase chain reaction and OUT polymerase chain reaction). Int J Mycobacteriol 11: 88-94 <https://doi.org/10.4103/ijmy.ijmy_253_21>
24. Tuzcu N, Köksal F. 2020: Genetic evaluation of Mycobacterium bovis isolates with MIRU-VNTR and spoligotyping. Turk J Med Sci 50: 2017-2023 <https://doi.org/10.3906/sag-1910-138>
25. Zachary JF 2017: Mechanisms of microbial infections. In: Zachary JF (Ed.): Pathologic Basis of Veterinary Disease. 6th edn. Elsevier, St. Louis, pp. 132-241
front cover
  • ISSN 0001-7213 (printed)
  • ISSN 1801-7576 (electronic)

Current issue

Archive