Ultrasonic Shock-Wave as a Control Mechanism for Liposome Drug Delivery System for Possible Use in Scaffold Implanted to Animals with Iatrogenic Articular Cartilage Defects

Míčková, A.; Tománková, K.; Kolářová, H.; Bajgar, R.; Kolář, P.; Šunka, P.; Plencner, M.; Jakubová, R.; Beneš, J.; Koláčná, L.; Plánka, L.; Nečas, A.; Amler, E.

doi:10.2754/avb200877020285

Acta Veterinaria > Archive > 2008, Vol. 77 > Issue 2 > Ultrasonic Shock-Wave as a Control…

Acta Vet. Brno 2008, 77: 285-289

https://doi.org/10.2754/avb200877020285

Ultrasonic Shock-Wave as a Control Mechanism for Liposome Drug Delivery System for Possible Use in Scaffold Implanted to Animals with Iatrogenic Articular Cartilage Defects

A. Míčková^1,2, K. Tománková³, H. Kolářová³, R. Bajgar³, P. Kolář^3,4, P. Šunka⁵, M. Plencner^1,2, R. Jakubová^1,2, J. Beneš⁶, L. Koláčná^1,2, L. Plánka⁷, A. Nečas⁸, E. Amler^1,2

¹Department of Biophysics, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
²Laboratory of Tissue Engineering, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
³Department of Medical Biophysics, Faculty of Medicine, Palacký University, Olomouc, Czech Republic
⁴Department of Orthopaedics, University Hospital in Olomouc, Czech Republic
⁵Institute of Plasma Physics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
⁶First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
⁷Department of Pediatric Surgery, Orthopaedics and Traumatology, Faculty Hospital Brno, Czech Republic
⁸Department of Surgery and Orthopaedics, Small Animal Clinic, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic

Received November 15, 2007
Accepted February 14, 2008

A short liposome exposure to ultrasonic waves with the intensity of I = 2 W/cm² at frequency f = 1 MHz was found to be a sufficient tool for liposome opening. In addition, shock-wave proved to be sufficient also for liposome content release. Both methods are useful tools to be used as control mechanisms for drug delivery systems based on liposomes. However, due to better focusing and low non-thermal side effects, shock-waves probably have a markedly higher potential for successful use.