Acta Vet. Brno 2010, 79: 127-133

https://doi.org/10.2754/avb201079010127

Expression of Claudin-7 Molecule in Canine Perianal GlandTumours

Csaba Jakab1, Miklós Rusvai1, Péter Gálfi2, Janina Kulka3

1Szent István University, Faculty of Veterinary Science, Department of Pathology and Forensic Veterinary Medicine, Budapest, Hungary
2Szent István University, Faculty of Veterinary Science, Department of Pharmacology and Toxicology, Budapest, Hungary
32nd Department of Pathology, Semmelweis University, Budapest, Hungary

Received January 2, 2008
Accepted September 8, 2009

The present study evaluated the expression of claudin-7 in 10 intact perianal gland and 67 hyperplastic and neoplastic lesions of the canine perianal (hepatoid) gland. The results have shown intense typical membrane expression of claudin-7 in intact perianal glands, hyperplasia, adenoma, differentiated and anaplastic carcinoma of this gland. In intact glands, hyperplasias, adenomas of the hepatoid gland, normal, hyperplastic and neoplastic basal cells never expressed claudin-7 molecule. Epitheliomas of the hepatoid gland were negative for claudin-7 molecule. Intense membrane-bound claudin-7 immunoreactivity was found in well-differentiated carcinomas, in addition claudin-7 overexpression in poorly differentiated carcinomas of the canine hepatoid gland. Claudin-7 seems to be one of the integral constituents of tight junction structures of intact perianal gland. In addition, claudin-7 seems to be helpful in distinguishing well-differentiated carcinomas and poorly differentiated carcinomas from epitheliomas of the gland; and in distinguishing well-differentiated carcinomas from adenoma of the perianal gland.

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