Smart nanofibres for specific and ultrasensitive nanobiosensors and drug delivery systems

Pashchenko, Aleksei; Stuchlíková, Simona; Varvařovská, Leontýna; Firment, Peter; Staňková, Laura; Nečasová, Andrea; Filipejová, Zita; Urbanová, Lucie; Jarošíková, Taťána; Nečas, Alois; Amler, Evžen

doi:10.2754/avb202291020163

Acta Veterinaria > Archive > 2022, Vol. 91 > Issue 2 > Smart nanofibres for specific and…

Acta Vet. Brno 2022, 91: 163-170

https://doi.org/10.2754/avb202291020163

Smart nanofibres for specific and ultrasensitive nanobiosensors and drug delivery systems

Aleksei Pashchenko^1,2,3, Simona Stuchlíková^1,4, Leontýna Varvařovská⁴, Peter Firment⁵, Laura Staňková⁶, Andrea Nečasová⁶, Zita Filipejová⁶, Lucie Urbanová⁶, Taťána Jarošíková⁴, Alois Nečas⁶, Evžen Amler^1,2,7

¹Charles University, Second Faculty of Medicine, Department of Biophysics, Prague, Czech Republic
²Czech Technical University in Prague, University Centre for Energy Efficient Buildings, Bustehrad, Czech Republic
³University of Sassari, Department of Biomedical Sciences, Sassari, Italy
⁴Czech Technical University in Prague, Faculty of Biomedical Engineering, Prague, Czech Republic
⁵FNsP J. A. Reimana Prešov, Department of Anaesthesiology and Intensive Medicine, Prešov, Slovakia
⁶University of Veterinary and Sciences Brno, Faculty of Veterinary Medicine, Brno, Czech Republic
⁷Student Science, Prague, Czech Republic

Received September 27, 2021
Accepted February 1, 2022

Biosensors are dynamically developing analytical devices for the detection of substrates or other bioactive substances. They can be used for quick gas or liquid analyses and the construction of sensitive detection systems. This review highlights the advances and development of biosensors suitable for human and veterinary medicine and, namely, a novel contribution of nanotechnology for ultrasensitive diagnosis and personalized medicine. The synergic effect of nanotechnology and biosensors opens a new dimension for effective treatment and disease detection at their early stages.

Keywords

Nanotechnology, detection, disease diagnosis, drug delivery.

Funding

The work was supported by the Technology Agency of the Czech Republic project No. TL03000207; by the Grant Agency of the Czech 338 Technical University in Prague, grant SGS21/177/OHK4/3T/17; by the Internal Creative Agency of the University of Veterinary Sciences Brno project number 2021ITA13; by the Technology Agency of the Czech Republic, project No. FV30311, Contract ID 2018FV30311; by funds of institutional research (TA 29) FVM UVS Brno; and by Project TRIO FV30311 (MPO ČR). The funders had no role in the study’s design, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.