Acta Vet. Brno 2022, 91: 163-170

Smart nanofibres for specific and ultrasensitive nanobiosensors and drug delivery systems

Aleksei Pashchenko1,2,3, Simona Stuchlíková1,4, Leontýna Varvařovská4, Peter Firment5, Laura Staňková6, Andrea Nečasová6, Zita Filipejová6, Lucie Urbanová6, Taťána Jarošíková4, Alois Nečas6, Evžen Amler1,2,7

1Charles University, Second Faculty of Medicine, Department of Biophysics, Prague, Czech Republic
2Czech Technical University in Prague, University Centre for Energy Efficient Buildings, Bustehrad, Czech Republic
3University of Sassari, Department of Biomedical Sciences, Sassari, Italy
4Czech Technical University in Prague, Faculty of Biomedical Engineering, Prague, Czech Republic
5FNsP J. A. Reimana Prešov, Department of Anaesthesiology and Intensive Medicine, Prešov, Slovakia
6University of Veterinary and Sciences Brno, Faculty of Veterinary Medicine, Brno, Czech Republic
7Student Science, Prague, Czech Republic

Received September 27, 2021
Accepted February 1, 2022

Biosensors are dynamically developing analytical devices for the detection of substrates or other bioactive substances. They can be used for quick gas or liquid analyses and the construction of sensitive detection systems. This review highlights the advances and development of biosensors suitable for human and veterinary medicine and, namely, a novel contribution of nanotechnology for ultrasensitive diagnosis and personalized medicine. The synergic effect of nanotechnology and biosensors opens a new dimension for effective treatment and disease detection at their early stages.


The work was supported by the Technology Agency of the Czech Republic project No. TL03000207; by the Grant Agency of the Czech 338 Technical University in Prague, grant SGS21/177/OHK4/3T/17; by the Internal Creative Agency of the University of Veterinary Sciences Brno project number 2021ITA13; by the Technology Agency of the Czech Republic, project No. FV30311, Contract ID 2018FV30311; by funds of institutional research (TA 29) FVM UVS Brno; and by Project TRIO FV30311 (MPO ČR). The funders had no role in the study’s design, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.


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